|
Showing 1 - 2 of
2 matches in All Departments
The crude methanolic extract and different fractions of plant
Boerhavia repens were subjected to a number of biological tests for
the evaluation of their pharmacological activity.The whole plant of
Boerhavia repens was extracted with methanol by cold extraction
method. The concentrated extract of the plant were then partitioned
into pet ether, carbon tetrachloride, dichloromethane and ethyl
acetate soluble fractions.The carbon tetrachloride, dichloromethane
and the ethyl acetate soluble fractions of the plant showed strong
anti-oxidant activity. The cytotoxicity evaluation of the plant
extracts were carried out by Brine Shrimp Lethality Bioassay. The
pet ether soluble fractions of the plant showed strong cytotoxic
activity. The crude methanolic extract and pet ether soluble
fraction at doses of 400 mg/kg exhibited strong analgesic activity,
anti-inflammatory and anti-pyretic activity. The different
fractions and the crude methanolic extract were also subjected to
anti-microbial assay. However no fractions exhibited strong
anti-microbial activity.
Medicinal plants are important source to be explored for the
discovery and development of newer, safer and effective drug
candidates. In medicinal plants research, bioactivity guided
phytochemical research can be considered as a rational approach.
The ethanopharmacological investigations of the study plant
Schoenoplectus grossus was carried out for the first time ever in
research lab by Professor Dr. Rahman's research group. The powdered
root of this plant was extracted with methanol and fractioned by
modified Kupchan partitioning method to provide petroleum ether,
carbon tetrachloride, dichloromethane, and ethyl acetate soluble
fractions. All fractions and methanol extract were investigated for
pharmacological activities on animal model. The analgesic,
antipyretic, anti-inflammatory, antihelmintic, and antidiarrheal
effects were analyzed on dose dependent manner by comparing with
standard reference drug. The extract was also screened out for
cytotoxic, antioxidant, and thrombolytic activity by in vitro
methods.
|
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.