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Hypertension has certainly been one of the topics most fre quently
discussed at symposia, meetings, and congresses during recent
years. There may be several reasons for this; three of them are
obvious: firstly, the fact that a large proportion of the world's
population is suffering from various forms of hypertensive disease;
secondly, increasing knowledge of the pathogenesis of hypertension
and of the disturbances underlying it; and, thirdly, the marked
progress which has been made in antihypertensive therapy over the
past fifteen years. When plans for the present symposium were being
drawn up, it was felt that it should not simply bring forth just
another meeting on hypertension, but should place particular
emphasis on those aspects which had not been adequately discussed
at previous symposia of this kind. Curiously enough, the topic
which appeared to have received least attention in the past was
therapy, although from the practical point of view this is by far
the most important. The choice of therapy as the main theme of the
whole symposium also seemed to be warranted in view of the
relatively long period that had elapsed since effective antihyper
tensive treatment became available; the time had in fact come now
to pass judgement on the benefits as well as the shortcomings of
drug treatment as available today.
International Symposia sponsored by ClBA Basle have been held once
a year since 1959 in various European countries. In con trast to
the many scientific meetings organised by the ClBA FOUN DATION
either at its headquarters in London or occasionally abroad, the
subjects dealt with at these International Symposia have con cerned
problems more directly related to ClBA'S own research work in the
pharmaceutical field. The various topics covered up to the present
reflect the far-reaching interests and the wide spread activities
that a pharmaceutical enterprise develops in quite diverse fields
of chemical, biological, and medical research, and to which the
ba.sic approach is an increasingly important prerequisite for the
development of a new and useful therapeutic agent. Iron metabolism
came into the sphere of interest in connection with CIBA'S research
on antibiotics and related natural products containing iron,
substances which act in their metal-free form as strong and
specific chelating agents. Of course, these observations,
interesting though they are, would not in themselves have justi
fied a symposium. It seemed, however, useful to examine the new
results from a wider perspective and to attempt to relate them to
present-day knowledge of iron metabolism in general its physiology,
its pathology, and therapeutic aspects. The success of a scientific
symposium depends on the concep tion of the programme and the
selection of the participants."
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