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S. Ren and E.J. Lien: CaCo-2 cell permeability vs human
gastrointestinal absorption: QSPR analysis.- J.C.G. Halford and
J.E. Blundell: Pharmacology of appetite suppression.- B. Olivier,
W. Soudijn and I. van Wijngaarden: Serotonin, dopamine and
norepinephrine transporters in the central nervous system and their
inhibitors.- D. Poyner, H. Cox, M. Bushfield, J.M. Treherne and
M.K. Demetrikopoulos: Neuropeptides in drug research.- M. Kumari
and M.K. Ticku: Regulation of NMDA receptors by ethanol.- H.
Horikoshi, T. Hashimoto and T. Fujiwara: Troglitazone and emerging
glitazones: new avenues for potential therapeutic benefits beyond
glycemic control.- Rosamund C. Smith and Simon J. Rhodes:
Applications of developmental biology to medicine and animal
agriculture
Founded in 1959 by its current Editor, the series has moved from
its initial focus on medicinal chemistry to a much wider scope.
Today it encompasses all fields concerned with the development of
new therapeutic drugs and the elucidation of their mechanisms of
action, reflecting the increasingly complex nature of modern drug
research. Invited authors present their biological, chemical,
biochemical, physiological, immunological, pharmaceutical,
toxicological, pharmacological and clinical expertise in carefully
written reviews and provide the newcomer and the specialist alike
with an up-to-date comprehensive list of prime references. Each
volume of Progress in Drug Research contains fully
cross-referencing indices which link the books together, forming a
virtually encyclopaedic work. The series thus serves as an
important, time-saving source of information for researchers
concerned with drug research and all those who need to keep abreast
of the many recent developments in the quest for new and better
medicines.
This book unveils a gap in the governance of development
projects that ultimately hinders effective, transparent and
accountable usage of resources. Illustrated with entertaining
examples, the book develops a Project Governance model. The models
six modules build an integrated, strategically oriented and
ethically reflected platform for a more truthful and efficient
cooperation in difficult projects or programs such as in
development.
In the treatment of infections caused by rapidly mutating viruses
like human immunodeficiency virus (HIV), combination therapy with
multiple drugs act ing by different mechanisms offers several
advantages over monotherapy. It may provide: synergistic effect,
possible reduction of dosages and side-effects, and reduction of
the chance of drug resistance. In the past few years, hun dreds of
HIV protease inhibitors have been synthesized and tested in order
to overcome the limitations of reverse transcriptase inhibitors
like zidovudine and others. In this review, emphasis is placed on
the development of HIV pro tease inhibitors as antiviral agents
against HIY, and structure-activity rela tionship analysis of
saquinavir and related compounds. Limitations of some protease
inhibitors and ways to overcome the shortcomings are presented.
Among these many protease inhibitors five have been marketed during
1995-1999. They are saquinavir, ritonavir, indinavir, nelfinavir
and ampre navir. Their different structural features, important
physicochemical, phar macokinetic and clinical profiles are
presented in a table form for easy com parison. It is hoped that in
the future new drugs based on additional mech anisms can be
developed for the treatment of AIDS. Contents 4 1 Introduction
....................................................................
. HIV protease as a target for chemotherapy
................................... . 2 5 Design of protease
inhibitors .................................................. . 3 5
Basis of rational design of HIV protease inhibitors
........................... . 3.1 5 New development of HIV protease
inhibitors ................................ . 6 3.2 HIV protease
inhibitors on the market ........................................ .
20 4 20 4.1 SAR of saquinavir and related compounds
.................................... ."
Founded in 1959 by its current Editor, the series has moved from
its initial focus on medicinal chemistry to a much wider scope.
Today it encompasses all fields concerned with the development of
new therapeutic drugs and the elucidation of their mechanisms of
action, reflecting the increasingly complex nature of modern drug
research. Invited authors present their biological, chemical,
biochemical, physiological, immunological, pharmaceutical,
toxicological, pharmacological and clinical expertise in carefully
written reviews and provide the newcomer and the specialist alike
with an up-to-date comprehensive list of prime references. Each
volume of Progress in Drug Research contains fully
cross-referencing indices which link the books together, forming a
virtually encyclopaedic work. The series thus serves as an
important, time-saving source of information for researchers
concerned with drug research and all those who need to keep abreast
of the many recent developments in the quest for new and better
medicines.
Geschenke und Gefalligkeiten, Entlassungen, Mobbing,
Billiglohnproduktion oder Einsatz von Cookies oder
Persoenlichkeitsprofilen - Das Spektrum an moeglichen
Spannungsfeldern im Unternehmensalltag ist gross. Mit der
Digitalisierung sind die ethischen Herausforderungen noch groesser.
Dieses Open Access Buch fuhrt Fuhrungskrafte in die Erfassung und
Loesung ethischer Dilemmas im Unternehmensalltag ein. Praxisnah und
konkret stellt es sieben Leitideen als ethisches Fundament und ein
Ablaufschema zur Loesung ethischer Dilemmas vor. 32 haufige
Spannungsfelder werden anhand von kurzen Fallbeispielen analysiert
und diskutiert. Das Buch prasentiert zudem einfache, aber auch
umfassende Good Practices eines modernen Integritatsmanagements. In
Zeiten, in denen der Ruf nach der Wahrnehmung von sozialer,
gesellschaftlicher und digitaler Verantwortung von Unternehmen
immer lauter wird, gibt dieses Lehrmittel den Fuhrungskraften einen
Leitfaden an die Hand, wie sie ethische Dilemmas im
Unternehmensalltag strukturiert angehen koennen. Die zweite Auflage
enthalt ein voellig neues Kapitel mit sieben Fallbeispielen zur
Corporate Digital Responsibility (CDR), das heisst, zur
Verantwortung von Unternehmen im Zeitalter der Digitalisierung. Der
Inhalt Grundbegriffe der Ethik Spannungsfelder in Organisationen
Ethische Dilemmas Leitideen guter Zusammenarbeit Fallbeispiele zum
Integritatsmanagement Fallbeispiele zur Corporate Digital
Responsibility (CDR) Good Practices im Integritatsmanagement Dies
ist ein Open-Access-Buch.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ Supplementum Florae Lapponicae Quam Edidit Dr. Georgius
Wahlenberg Soren C. Sommerfeldt, Georg Wahlenberg Borgia et
Grondahl, 1826 Science; Life Sciences; Botany; Science / Life
Sciences / Botany
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ Om Mahabharata's Stilling In Den Indiske Literatur: I. Forsog
Pa At Udskille De Aeldste Bestanddele ... Soren Sorensen R. Klein,
1883 Literary Criticism; Asian; Indic; Literary Criticism / Asian /
Indic; Mahābhārata; Religion / Hinduism / Sacred Writings
Title: Kj benhavns Belejring og Fyens Gjenerobring ... 1658-59.
Efter Forfatterens D d samlede af P. Fr. Rist og H. w.
Harbou.Publisher: British Library, Historical Print EditionsThe
British Library is the national library of the United Kingdom. It
is one of the world's largest research libraries holding over 150
million items in all known languages and formats: books, journals,
newspapers, sound recordings, patents, maps, stamps, prints and
much more. Its collections include around 14 million books, along
with substantial additional collections of manuscripts and
historical items dating back as far as 300 BC.The GENERAL
HISTORICAL collection includes books from the British Library
digitised by Microsoft. This varied collection includes material
that gives readers a 19th century view of the world. Topics include
health, education, economics, agriculture, environment, technology,
culture, politics, labour and industry, mining, penal policy, and
social order. ++++The below data was compiled from various
identification fields in the bibliographic record of this title.
This data is provided as an additional tool in helping to insure
edition identification: ++++ British Library So rensen, S ren
Anton.; Harbou, Frederik Hans Walther.; Rist; 1896. vii, 193 p.; 8
. 9431.k.3.
This is a reproduction of a book published before 1923. This book
may have occasional imperfectionssuch as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed
worksworldwide. We appreciate your understanding of the
imperfections in the preservation process, and hope you enjoy this
valuable book.++++The below data was compiled from various
identification fields in the bibliographic record of this title.
This data is provided as an additional tool in helping to ensure
edition identification: ++++ Supplementum Linguae Latinae, Sive
Observationes Ad Lexicon Fabro-Cellarianum Christian Falster, Soren
Lintrup
Please note that the content of this book primarily consists of
articles available from Wikipedia or other free sources online.
Sport Bissau e Benfica, usually known as Benfica de Bissau, is a
football (soccer) club from Bissau, Guinea-Bissau. Bissau is the
capital city of Guinea-Bissau. The city's borders are conterminous
with the Bissau Autonomous Sector. In 2007, the city had an
estimated population of 407,424 according to the Instituto Nacional
de Estat stica e Censos. The city which is located on the Geba
River estuary, off the Atlantic Ocean, is the country's largest
city, major port, administrative and military centre.
Food production will have to increase in the next 50 years to meet
the demand from a growing population and changed food habits, as
e.g. for higher meat consumption. The increased production will
have to be based on rain-fed agriculture or more effective
irrigation strategies, and will have to be mainly in the tropics,
since further enhancement in productivity in the western
agriculture is a slow process, if possible at all. Climate change
will become a major threat to this demand/supply equation, since
many new problems will hamper the productivity gain that otherwise
could have been achieved. Simple movement of genetic material or
management techniques (North South or South North) to overcome
future climate change, are doubtful, since photoperiodic control of
most tropical species are very strong. Establishing more local
breeding programs in a wider number of tropical species than
currently, is highly relevant for continuously adapting to changing
climate. Apart from crop breeding, many new research areas within
plant physiology needs further work.
Please note that the content of this book primarily consists of
articles available from Wikipedia or other free sources online. Two
popular American sports were invented in New England. Basketball
was invented by James Naismith in Springfield, Massachusetts, in
1891. Volleyball was invented by William G. Morgan in Holyoke,
Massachusetts, in 1895. Also, the first American hockey game was
played in Connecticut. The region is famous for its passion for
baseball and the Boston Red Sox, as well as for the intense rivalry
between the Red Sox and the New York Yankees. On November 1, 1924,
the Boston Bruins of the National Hockey League became the first
NHL franchise to be based in the United States, and the second
oldest surviving major professional sports team in Boston, after
the Red Sox. The Bruins' historic rivalry with the Montreal
Canadiens for ice hockey fans in the Boston area has, at times,
reached the level of intensity of the Yankees - Red Sox rivalry in
professional baseball in the region.
Please note that the content of this book primarily consists of
articles available from Wikipedia or other free sources online.
Sport Club Ca adense is a sports club from Ca ada de G mez, Santa
Fe Province, Argentina. The institution is better known for both
its football and basketball teams. The club's football team plays
in the Liga Ca adense de F tbol, a local tournament which Sport
Club obtained 18 times, becoming the top title-winner in league
history.The basketball team currently plays at the Liga B, a
regionalized division of the Liga Nacional de B squetbol, which
Sport Club participated 11 seasons. The team's most important
achievement was in 1990, when reached the final games against
Atenas de C rdoba but Sport Club finally was defeated 0-3.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
A renewed interest in forest damage monitoring has led to a shift
in information requirements, as the crown condition assessments
initiated in the 1980s in response to the threats posed by air
pollution need to be complemented by assessments of specific
damages and their causes as well as populations of plausible
damaging agents and early signs of damage outbreaks. The aims of
this project were to assess past and current methods of monitoring
forest damage in Sweden and to set up a new monitoring system that
would be better adapted to the information requirements. The
current information needs assessments of forest damage to be timely
and to be made at several spatial scales. To meet the information
needs a new Swedish forest health assessment system has been
developed and includes several interacting components targeting the
information requirements for strategic and operational decision
making, and accommodates a mechanism for continuously expanding the
knowledge base. The new system is likely to become increasingly
important due to anticipated climate change and should be of
interest for anyone concerned in forest damage and with monitoring
activities.
This book is about the Danish "Pastor-Poet" Kaj Munk, who in the
1930's was Scandinavia's most talked about playwright. It describes
his early fascination with Europe's "Strong Men," and with German
theater. The book contains an in-depth analysis of his early
disillusionment with democracy, and then his growing awareness of
the true nature of Nazism and Fascism. It was in particular the
Nazi treatment of Europe's Jews that brought Kaj Munk to the front
of Danish resistance. He denounced Hitler and the German occupiers
from the pulpit and, despite numerous warnings, refused to keep
quiet. He was assassinated by the Nazis on January 4, 1944. Kaj
Munk was a beacon of light in Denmark's darkest hour, one of that
nation's most noted and discussed men of letters, and he remains so
to this day.
La aproximacion al estudio del desarrollo exige el esclarecimiento
de la concepcion del desarrollo socio economico en general para
llegar al desarrollo socio economico local en particular, abordando
ademas la necesidad de un desarrollo local perdurable que se
sustente en el potencial endogeno de desarrollo con que cuenta una
localidad y tomando como referente los antecedentes, retos y
perspectivas del desarrollo socio economico local. El desarrollo
distingue y se conforma como condicion integral del
desenvolvimiento de la sociedad, por tanto su investigacion exige
vision de totalidad en su enfoque y analisis, lo cual va mas alla
de la vision global, ya que enfatiza en las interconexiones
internas del objeto de investigacion, las cuales constituyen el
nucleo cohesionador del sistema. La metodologia de su investigacion
le otorga complejidad y le enfrenta a las concepciones
metodologicas preponderantes en la literatura economica. No niega
aspectos positivos de su investigacion, sino que le integra bajo
una nueva exigencia y perspectiva epistemologica."
Studienarbeit aus dem Jahr 2003 im Fachbereich BWL -
Wirtschaftspolitik, Note: 1,7, Universitat Potsdam
(Wirtschaftswissenschaften), Veranstaltung: Seminar zur
Wirtschaftspolitik, Sprache: Deutsch, Anmerkungen: Umweltpolitische
Themen haben an Bedeutung gewonnen. Im Zuge dieses Trends hat sich
auch ein neues Instrument zur Losung von umweltpolitischen
Herausforderungen zunehmend etabliert: Freiwillige
Selbstverpflichtungserklarungen (FSVE). Zielsetzung dieser Arbeit
ist die Definition des Begriffes FSVE und die Einordnung in das
umweltpolitische Instrumentarium des Staates., Abstract:
Umweltpolitische Themen, wie Klimaschutz oder Abfallentsorgung,
haben seit den 70er Jahren in Deutschland an Bedeutung gewonnen. Im
Zuge dieses Trends hat sich auch ein neues Instrument zur Losung
von umweltpolitischen Herausforderungen zunehmend etabliert:
Freiwillige Selbstverpflichtungserklarungen (FSVE). Allein zwischen
1980 und 1997 sind in Deutschland 93 FSVE ausgehandelt worden, in
den Niederlanden sogar 107 und in der Europaischen Union (EU) 322.
Im Vergleich zu Japan erscheinen diese Zahlen jedoch noch auf
niedrigem Niveau zu liegen, dort werden jahrlich ca. 2.000 FSVE
abgeschlossen. Wie ein Uberblick uber die wichtigsten Erklarungen
im Anhang darstellt, werden FSVE in Deutschland fast
ausschliesslich im Umweltschutz abgeschlossen. Es ist jedoch zu
erwahnen, dass FSVE nicht nur in der Umweltpolitik eine Rolle
spielen, sondern sich auch in anderen Politikbereichen erfolgreich
etabliert haben. So gibt es im Bereich der Medien eine
Werbedisziplin und eine Freiwillige Selbstkontrolle (FSK) der
Filmwirtschaft. Auch im Bereich des Aussenhandels gibt haufig
Selbstverpflichtungen in Form von freiwilligen
Handelsbeschrankungen auf Exporte oder Importe. Da FSVE jedoch
uberwiegend im Bereich der Umweltpolitik eingesetzt werden5,
fokussiert diese Arbeit ebenfalls auf diesen Bereich. Der Einsatz
von FSVE als praktische Umsetzung des Kooperationsprinzips in der
Umweltpolitik wird in wi
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