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The volumes of this classic series, now referred to simply as
'Zechmeister' after its founder, L. Zechmeister, have appeared
under the Springer Imprint ever since the series' inauguration in
1938. The volumes contain contributions on various topics related
to the origin, distribution, chemistry, synthesis, biochemistry,
function or use of various classes of naturally occurring
substances, ranging from small molecules to biopolymers. Each
contribution is written by a recognized authority in his field and
provides a comprehensive and up-to-date review of the topic in
question. Addressed to biologists, technologists, and chemists
alike, the series can be used by the expert as a source of
information and literature citations and by the non-expert as a
means of orientation in a rapidly developing discipline.
The authors present a basic model of the Bayesian implementation
problem and then consider its application in areas including
classical pure exchange economies, public goods provision, auctions
and bargaining.
For centuries preparations containing resin from the root of
Thapsia garganica L. (Fig. 1) have been used in Arabian and
European medicine for treatment of pulmonary diseases, catarrh and
as counterirritants for relief of rheumatic pains (1). The
properties of the resin were described already by Theophrastos
(372-287 B. C. ), Dioscorides (approximately A. D. 50), and Plinius
(A. D. 24-79) (2). Radix Thapsiae and Resina Thapsiae have been
included in several pharmacopoeias, the latest in the French
pharmacopoeia from 1937. The two major active principles were about
Fig. I. Thapsia garganica References, pp. 163-167 Sesquiterpenoids
from Thapsia Species 131 Thapsigargin (1), Rl: Oct, R2= But
Thapsigargicin (2), Rl= Hex, R2 = But Thapsitranstagin (3), Rl:
iVai, R2= 2-MeBut Thapsivillosin A (4), Rl= Ang, R2= Sen
Thapsivillosin B ( 5), Rl: Ang, R2= 2-MeBut Thapsivillosin C ( 6),
Rl= Oct, R2= 2-MeBut Thapsivillosin D ( 7), Rl: 6-MeOct, R2= Sen
Thapsivillosin E ( 8), Rl: 6-MeOct, R2= 2-MeBut Thapsivillosin G (
9), Rl= 6-MeHcp, R2= 2-MeBut Thapsivillosin H ( 10), Rl or R2= Ang
or Sen Thapsivillosin I ( 11), Rl= Ang, R2= But Thapsivillosin J (
12), Rl: iVai, R2= But Thapsivillosin K ( 13), Rl: Sen, R2= 2-MeBut
Chart 1. Hexaoxygenated thapsigargins found in Thapsia two decades
ago found to be the sesquiterpene lactones thapsigargin (1) and
thapsigargicin (2) (3).
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