Genomic and Epigenomic Biomarkers of Toxicology and Disease The latest developments in biomarker research applicable to toxicology and medicine Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain. Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas. With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas. Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes: A thorough introduction to microRNAs as non-invasive biomarkers of toxicity and chemical hazard Comprehensive explorations of extracellular vesicle-associated miRNAs as toxic biomarkers, as well as transcriptomic applications in toxicology and medicine Practical discussions of circulating miRNAs as biomarkers of metal exposure, as well as microRNAs biomarkers of malignant mesothelioma In-depth examinations of the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic with a focus on microRNAs Perfect for researchers, toxicologists, risk assessors, and regulators, Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment.

Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as "nanotoxicity" - the study of the toxicity of nanomaterials.

"Nanotoxicity: From" in vivo "and" in vitro "Models to Health Risks" provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include: biomarkers for nanotoxicity assessmentnanotoxicity assessment by gene expression analysis"in vivo" and "in vitro" models for nanotoxicity testingmechanisms of nanotoxicitypharmakokinetics of nanomaterialsnanotoxicity of foods including food processing, food packaging and food safetynanotoxicity of drugs including drug development and drug deliverynanotoxicity of cosmetics and consumer productshealth and environmental impact of nanotoxicitysafety evaluation of nanomaterialsregulatory impact of nanomaterials

"Nanotoxicity: From" in vivo "and" in vitro "Models to Health Risks" is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology. Topics covered include: * mechanistic toxicogenomics* analysis and interpretation of toxicogenomic data* principles of data mining in toxicogenomics* design issues in toxicogenomics studies* sources of variability in toxicogenomic assays*Escherichia coli stress response as a tool for detection of toxicity* toxicogenomics as a tool to assess immunotoxicity* toxicogenomics and ecogenomics for studying endocrine disruption and basic biology* use of toxicogenomics as an early predictive tool for hepatotoxicity* nutrigenomics: the application of genomic signatures in nutrition-related research* application of toxicogenomics in drug discovery* potential uses of toxicogenomic biomarkers in occupational health and risk assessment* usefulness of toxicogenomics in the regulatory environment* perspectives on toxicogenomics at the US Environmental Protection Agency Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currently engaged in toxicogenomics, and will also be of interest to researchers working in toxicology, genetics, medicine, pharmacology, and food sciences, and to regulators and risk assessors of drug, food, environmental and agricultural products.

A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine * Presented by internationally recognized investigators in this exciting field of scientific research * Provides an insight into the current trends and future directions of research in this rapidly developing new field * A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government

Providing insight into the current trends and future directions of research in this rapidly developing new field, microRNAs in Toxicology and Medicine is a comprehensive and authoritative compilation of developments in the role of microRNAs in disease and their use in toxicology, presented by internationally recognized investigators in a single, accessible volume. This valuable and excellent source of authoritative and up-to-date information for investigators, toxicologists, drug industry, risk assessors, and regulators in academia, industry, and government reflects the multidimensional and multidisciplinary character of this emerging area of research.

The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.

Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.

"Toxicology and Epigenetics" reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of "in vivo" and "in vitro "models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.

Topics covered include: environment, epigenetics and diseasesDNA methylation and toxicogenomics chromatin at the intersection of disease and therapyepigenomic actions of environmental arsenicalsenvironment, epigenetics and cardiovascular healthtoxicology, epigenetics and autoimmunityocular epigenomics: potential sites of environmental impact in development and diseasenuclear RNA silencing and related phenomena in animalsepigenomics - impact for drug safety sciencesmethods of global epigenomic profilingtranscriptomics: applications in epigenetic toxicology

"Toxicology and Epigenetics" is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

"Frontiers in Toxicology" is the essential tool for toxicologists and pharmacologists working in academia, industry and regulatory bodies looking to stay at the forefront of three of the most important and upcoming areas of toxicology: toxicogenomics, hepatotoxicity and nanotoxicity.

Insights from leading researchers into the current trends and future directions of research are presented in three volumes. Each volume provides details on recent scientific discoveries, rules of best practice and addresses how national and international regulatory agencies will deal with the safety issues associated with toxicology. Many of the chapters are written by authors working for the US Food and Drug Administration, including Dr. Saura C. Sahu himself.

Titles included in the three volume set:

Nanotoxicity: From In Vivo and In Vitro Models to Health Risks - August 2009

Toxicogenomics: A Powerful Tool for Toxicity Assessment - October 2008

Hepatotoxicity: From Genomics to In Vitro and In Vivo Models - December 2007

Each volume is also available to purchase individually.

This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals.

Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action.

This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science.