The Guest Editors, coming from the Critical Care Medicine Department in the NIH, are the top thought leaders in the area of infections in critical care. Their topic selections in this issue reflect the most clinically relevant and current information. The issue specifically covers the following topics: Catheter-related bloodstream infections: special considerations in diagnosis in the ICU; Sepsis-How does the new definition help clinicians; Therapeutic drug monitoring of antibiotics; High containment pathogen preparation; Multidrug resistant gram negative infections and enterococcus; Strategies to prevent transmission of resistant organisms; Antibiotic Stewardship: What the intensivist should know; C. Difficile infection in the ICU; Immunocompromised critically ill; Rapid diagnostics: The use of procalcitonin; Respiratory viruses in the ICU: Significance of rhino/rsv updates/adenovirus metapneumovirus; Management of invasive fungal disease in the ICU; Inhaled/Nebulized antibiotics. Infectious disease physicians and intensivists will be armed with the information they need to diagnose and treat patients with infections in the ICU.

In this issue of Infectious Disease Clinics of North America, guest editors Drs. Naomi P. O'Grady and Sameer Kadri bring their considerable expertise to the topic of Complex Infectious Diseases Issues in the Intensive Care Unit. Affected immunity of patients with COVID-19 has made management of complex infectious diseases in the intensive care unit more important than ever. This issue provides key updates for managing these complex infectious diseases and includes current clinical information for COVID-19 patients, making this a state-of-the-art collection of review articles for practicing infectious disease physicians. Contains 13 practice-oriented topics including timing and spectrum of antibiotic treatment for suspected sepsis and septic shock; preparing an ICU for a lethal viral respiratory pandemic; rapid implementation of a system-level ICU pandemic surge staffing amidst quarantined staff and infection control barriers; management of serious SARS-CoV-2 infection with immunotherapies; supportive care in patients with critical COVID-19; and more. Provides in-depth clinical reviews on complex infectious diseases issues in the ICU, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.