Fertility preservation has become one of the most important and fast growing fields of reproductive medicine. Although there are several strategies for fertility preservation in female, most of them are still considered experimental. It is important to perfect the existing technologies, but also developing new strategies should be actively sought. The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles. One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and in somatic cells, DNA damage and repair mechanism, apoptosis and autophagy, and other poorly understood molecular mechanisms. To develop clinically effective and safe strategies for fertility preservation, it is essential to know and understand the fundamentals of oocyte and ovarian biology at the molecular level. Thus, the purpose of this edition is to review the current progress in research related to molecular and genetic control of oocyte development that can be applied to fertility preservation. The main topics that are discussed in this publication include molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics.

This new edition provides a much-needed reference book to accommodate emerging and expanding knowledge in fertility preservation, the rapidly growing field of reproductive medicine associated with advances in oncology. Written by a team of world-leading experts in the field and comprehensive in its scope, the book covers the full range of techniques and scientific concepts in detail. It opens with an introduction to fertility preservation in both cancer and non-cancer patients, followed by fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of ovarian tissue, and in-vitro follicle culture. Concluding chapters address new technologies, as well as ethical, legal and religious issues. The book has been thoroughly updated, includes additional contributors, and now provides greater focus on practical and clinically relevant issues. Richly illustrated throughout, this is a key resource for clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.

Fertility preservation has become one of the most important and fast growing fields of reproductive medicine. Although there are several strategies for fertility preservation in female, most of them are still considered experimental. It is important to perfect the existing technologies, but also developing new strategies should be actively sought. The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles. One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and in somatic cells, DNA damage and repair mechanism, apoptosis and autophagy, and other poorly understood molecular mechanisms. To develop clinically effective and safe strategies for fertility preservation, it is essential to know and understand the fundamentals of oocyte and ovarian biology at the molecular level. Thus, the purpose of this edition is to review the current progress in research related to molecular and genetic control of oocyte development that can be applied to fertility preservation. The main topics that are discussed in this publication include molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics. "

This user-friendly reference assists in the initial evaluation and treatment of the most frequently encountered problems in emergency medicine, both common and potentially life-threatening. The largest section of the book consists of 97 of the most common or important emergency medicine problems experienced by adult, pediatric, and geriatric populations. Each chapter in this section includes the presenting problem, immediate questions, differential diagnosis, laboratory and diagnostic data, and treatment plan. Additional chapters such as toxicologic emergencies, laboratory diagnosis, procedures, blood component therapy, and commonly used medications are also included and enhance the books value as a single-source reference.

Key Features:

*Logically organized, quick-access reference to the evaluation and management of problems encountered in the emergency department setting - essential information is located immediately and provides a complete picture of the initial evaluation and treatment of specific problems

*Problem-oriented approach to the information is uniquely suited to the way in which emergency medicine is taught and practiced

*Differential diagnosis, key laboratoy and diagnostic tests, and treatment plans for 97 of the most commmon problems that present in the emergency department

*Chapters on laboratory and diagnostic tests, procedures, and commonly used medications - highlight important information in the management of the medical patient