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Laboratory methods play a crucial role in establishing the
diagnosis, monitoring the therapy, preventing the transmission of
extra pulmonary tuberculosis. Conventional methods like smear and
culture are either less sensitive or time consuming. Newer
diagnostic tools such as BacT/Alert and Polymerase chain reaction
takes less time with high sensitivity. However, both false negative
and false positive results are reported on PCR, so PCR alone should
not be used as a criterion for initiating or terminating the
therapy. This should be supported by clinical, radiological,
cytological and other microbiological findings to guide the
clinician in decision making for appropriate therapy whenever
possible.
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