Myotonic dystrophy is a multisystemic disorder. The epidemiology of DM is examined in the first chapter of this book as well as potential therapeutic strategies. The authors then go on to review the various involvement of the endocrine system in myotonic dystrophy and therapeutic strategies are proposed. The fourth chapter gives an overview on the diagnostic assessment and management of distinct clinical manifestations of CNS (Central Nervous System) involvement in DM patients, and the main topics regarding its pathogenesis are explored. The next chapter focuses on the strategy of neuromuscular blockage for patients with myotonic dystrophy, especially focusing on premedication, induction of anaesthesia, response to muscle relaxants, the crucial points of safe anaesthesiological care and other perioperative triggers. The development of biomarkers is of high importance in the diagnosis and monitoring of diseases and thus is examined with relation to DM1 (myotonic dystrophy type 1) patients. Other chapters summarize the different rehabilitative approaches that have been proposed in this disease; the novel, interesting findings of therapeutic potential to target DM1 with small molecule kinase inhibitors and the promises his may provide to this devastating disorder; the controversial, phenotypical consequences of the interrupted alleles on DM1 patients; and the sleep disorders associated with myotonic dystrophies.

"The Adventures of Annie and Ellie" is a series of stories written for young children to help instill Scriptural and moral values in their lives while they are young so that it becomes a part of their everyday choices as they mature.

Just imagine that people suddenly lost most of their money and Santa Claus told children that he would no longer be sending presents. Wouldn't the world be a miserable place? When Father Christmas Resigned is the story of how one young girl's determination to help a man in need leads to new hope for children and their parents everywhere.

This is the ultimate novel of self-discovery and self-love for those who are coming out of hibernation and ready to do some emotional spring cleaning, or for those who are simply looking for a renewed spirit.