"Even though the saliva lacks the drama of blood, sincerity of sweat, emotions of tears saliva should be used as biomarker to detect pregnancy, diabetes mellitus, oral pre cancer & cancer, infectious diseases and also to catch the suspect by eliciting DNA from saliva over the bite marks in forensic odontolgy.This may allow a diagnosis of cancer to be made at an earlier stage, giving patients more choice in various treatment options. Doctors hope that, advancements in salivary diagnostics in the future will replace invasive biopsies and provide new avenues in early detection and diagnosis.It is a perfect medium for surveillance of health and disease. Saliva is ideal for screening premalignant and malignant oral neoplasms because of its anatomical poximity.Saliva contains specific biomarkers associated with either a healthy or diseased state."

The burgeoning advances in the domain of science & technology in general and medical field in particular have provided better insight into etiopathogenesis, clinical course, diagnosis, and treatment of oral diseases.OSMF was known as Vidari in the ancient Indian medical literature since the time of Sushrutha.In 1952 Schwartz described 5 Indian women living in Kenya with a condition of the oral mucosa including the palate and the pillars of the fauces, which he called "atrophica idiopathica mucosae oris." Initial symptoms are inability to tolerate spicy food Oral mucosa becomes blanched, usually symmetrically. As the disease progresses, thick inelastic fibrous bands appears in the submucousal layer of buccal mucosa, faucial pillars, floor of the mouth and tongue. The alterations in the plasma lipid profile levels have been found to be associated with etiology of breast cancer, colorectal cancer, head & neck cancer patients. However, only a few studies has been done on lipid profile in oral submucous fibrosis.The present study was carried out to evaluate the plasma/serum lipid profile in patients with oral sub mucous fibrosis patients with their different histopathological grades.

Although histopathology remains the gold standard for most immunobullous muco-cutaneous diseases, it must be recognized that not all skin lesions are amenable to definitive specific histologic diagnosis.The histologic diagnosis in turn is used by clinicians to aid in the management of patients. The most accurate diagnosis is the one that most closely correlates with clinical out come & helps to direct the most appropriate clinical intervention. This book aids observers to make appropriate histologic diagnostic findings using immunofluorescence techniques. This book is organized into 4 sections including Introduction, Fluorecscent Microscopy, Immunofluorescence & its techniques, and Immunofluorescence findings in immunobullous diseases like Intra epidermal immunobullous diseases & Sub-epidermal immunobullous diseases.

Cancer is a worldwide public health problem. Each year, 6 million people die from cancer and 8.1million new cases are diagnosed.Cancers, however, arise from the host's own tissues, and thus almost all the genes expressed by tumors are also expressed by normal tissues. Can the immune system attack "altered self" while sparing "self"? Another question is why the immune system would evolve to fight tumors? Nevertheless, immune recognition of cancers has now been well documented in humans. The main indicator of cancer is the uncontrolled growth and dispersion of cells as a result of abnormal changes to the genetic material contained in those cells. This book is an attempt to throw light on the basic immunology, the role of immune intervention in the prevention or treatment of human cancers and an insight into the recent advances in the field of tumour immunology.