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"Even though the saliva lacks the drama of blood, sincerity of
sweat, emotions of tears saliva should be used as biomarker to
detect pregnancy, diabetes mellitus, oral pre cancer & cancer,
infectious diseases and also to catch the suspect by eliciting DNA
from saliva over the bite marks in forensic odontolgy.This may
allow a diagnosis of cancer to be made at an earlier stage, giving
patients more choice in various treatment options. Doctors hope
that, advancements in salivary diagnostics in the future will
replace invasive biopsies and provide new avenues in early
detection and diagnosis.It is a perfect medium for surveillance of
health and disease. Saliva is ideal for screening premalignant and
malignant oral neoplasms because of its anatomical poximity.Saliva
contains specific biomarkers associated with either a healthy or
diseased state."
The burgeoning advances in the domain of science & technology
in general and medical field in particular have provided better
insight into etiopathogenesis, clinical course, diagnosis, and
treatment of oral diseases.OSMF was known as Vidari in the ancient
Indian medical literature since the time of Sushrutha.In 1952
Schwartz described 5 Indian women living in Kenya with a condition
of the oral mucosa including the palate and the pillars of the
fauces, which he called "atrophica idiopathica mucosae oris."
Initial symptoms are inability to tolerate spicy food Oral mucosa
becomes blanched, usually symmetrically. As the disease progresses,
thick inelastic fibrous bands appears in the submucousal layer of
buccal mucosa, faucial pillars, floor of the mouth and tongue. The
alterations in the plasma lipid profile levels have been found to
be associated with etiology of breast cancer, colorectal cancer,
head & neck cancer patients. However, only a few studies has
been done on lipid profile in oral submucous fibrosis.The present
study was carried out to evaluate the plasma/serum lipid profile in
patients with oral sub mucous fibrosis patients with their
different histopathological grades.
Although histopathology remains the gold standard for most
immunobullous muco-cutaneous diseases, it must be recognized that
not all skin lesions are amenable to definitive specific histologic
diagnosis.The histologic diagnosis in turn is used by clinicians to
aid in the management of patients. The most accurate diagnosis is
the one that most closely correlates with clinical out come &
helps to direct the most appropriate clinical intervention. This
book aids observers to make appropriate histologic diagnostic
findings using immunofluorescence techniques. This book is
organized into 4 sections including Introduction, Fluorecscent
Microscopy, Immunofluorescence & its techniques, and
Immunofluorescence findings in immunobullous diseases like Intra
epidermal immunobullous diseases & Sub-epidermal immunobullous
diseases.
Cancer is a worldwide public health problem. Each year, 6 million
people die from cancer and 8.1million new cases are
diagnosed.Cancers, however, arise from the host's own tissues, and
thus almost all the genes expressed by tumors are also expressed by
normal tissues. Can the immune system attack "altered self" while
sparing "self"? Another question is why the immune system would
evolve to fight tumors? Nevertheless, immune recognition of cancers
has now been well documented in humans. The main indicator of
cancer is the uncontrolled growth and dispersion of cells as a
result of abnormal changes to the genetic material contained in
those cells. This book is an attempt to throw light on the basic
immunology, the role of immune intervention in the prevention or
treatment of human cancers and an insight into the recent advances
in the field of tumour immunology.
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