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This volume represents a collection of contributions from the 6th
International Conference on Eicosanoids and Other Bioactive Lipids
in Cancer, Inflammation, and Related Diseases held in Boston from
September 12-15, 1999. The mission of this meeting was to bring
together senior and junior investigators to both announce and
examine their recent advancements in cutting-edge research on the
roles and actions of lipid mediators and their impact in human
physiology and disease pathogenesis. The meeting focused on new
concepts in these areas of interest to both clinicians and
researchers. The program included several outstanding plenary
lectures and presentations by leading experts in the fields of
cancer and inflammation. In addition, the Boston meeting presented
three Young Investigator awards, one in each of the major focus
areas. The meeting was exciting and proved to be very memorable.
The program was developed with an emphasis on recent advances in
molecular and of lipid mediators relevant in cellular mechanisims
involved in the formation and actions inflammation and cancer.
Plenary lectures were presented by Prof. Bengt Sammuelsson
(Karolinska Institute, Stockholm; 1982 Nobel Laureate in Physiology
or Medicine) and Prof. E. 1. Corey (Harvard University; 1990 Nobel
Laureate in Chemistry). Both of these plenary lectures were held on
Day 1, which set an exciting tone for this meeting. Immediately
following these plenary lectures, three simultaneous breakout
sessions were held, one of inflammation, a second on cancer and
synthesis of novel inhibitors, and a third on
enzymes-lipoxygenases/cyclooxygenases and inhibitors.
In the last decade, research on platelet-activating factor (PAF)
has expanded exponentially. Previous conferences on PAF in Paris,
1983, and the subsequent conferences in Gatlinburg, Ten nessee,
Tokyo, Snowbird, Utah, and Berlin, at three-yearly intervals, have
chronicled the devel opments in the field ofPAF. This volume
records the proceedings of the Fifth International Con gress on PAF
and Related Lipid Mediators, held at the Free University Medical
Hospital Ben jamin Franklin in Berlin, from September 12-16, 1995.
We are very much indebted to Free Uni versity Berlin for providing
tremendous facilities and financial support. It was a great
pleasure to have positive and generous input from the German
Science Council (DFG), Bonn, Germany, and British.Biotech, Oxford,
United Kingdom. Their support was crucial in making the congress a
scientific success. Twenty other organizations provided additional
financial support, for which we extend our deepest appreciation.
The editors would like to thank all of those who participated in
this congress and the authors for their contributions. The
organization and planning of the Berlin Congress were carried out
by an organizing committee. We gratefully acknowledge the support
and assistance of the organizing commit tee members, especially
Renate Nigam and Renate Roux for their untiring efforts to make the
congress successful. Many colleagues also supported the congress
with dedication, hard work, and expert input. We are grateful to
them. We also wish to acknowledge the support of G. Sravan Kumar
and Louis Kock for their efforts in producing this volume."
This volume constitutes, in part, the proceedings of the Hong Kong
Conference on "Eicosanoids and Other Bioactive Lipids in Cancer,
Inflammation, and Radiation Injury" held in Hong Kong in October
1995. It contains papers by the symposium speakers, as well as
poster contributions from researchers in this field. Since the
discovery of "PROSTAGLANDIN-LIKE' substances 60 years ago. much has
been learned. EICOSANOID is the new term that is used to include
prostaglandins. thromboxanes, leukotrienes, lipoxins, isoprostanes,
depoxilins, hydroxy acids, epoxy and hydroperoxy fatty acids. The
conference focussed on recent development in underatanding the role
of EICOSANOIDS in inflammation, cancer, and radiation damage. At
the confer- ence, we also highlighted advances in newly developing
areas such as "NO," "A POP- TOSIS and "ANANDAMIDE." The discovery
of the structures of genes that encode several key enzymes and
receptors of the Eicosanoid cascade, has allowed us to include
reports in the "Alteration of the Gene Expression" section that
reflects the most recent de- velopments in regulation for
PGH-synthase and lipoxygenases. The editors are convinced that this
volume will be an up-to-date and useful reference for investigators
in both basic and clinical research.
This volume contains the proceedings of the First International
Conference on Eicosanoids and Other Bioactive Lipids in Cancer and
Radiation Injury held in Detroit, Michigan on October 11-14, 1989.
The program consisted of 83 oral and 29 poster presentations, 74 of
which are included in these proceedings. The major sponsors of the
conference were the Armed Forces Radiobiology Research Institute,
located in Bethesda, Maryland, the Radiation Oncology Research and
Development Center of the Gershenson Radiation Oncology Center,
Harper Hospital in Detroit, Michigan, and Schering AG of West
Germany. Eighteen other organizations provided additional support.
The conference was unique in its attempt to link the eicosanoid and
lipid researchers in the radiobiology and cancer disciplines. The
diverse roles that eicosanoids and other bioactive lipids play in
these biological phenomena including the participation of lipid
oxidation in conversion of procarcinogens, positive and negative
modulation of tumor growth, immunomodulation, tissue injury, and
yet protection and enhancement of cancer therapy, necessitated
scientific interaction to sort out and understand these complex and
sometimes contradictory observations. The success of this effort is
reflected not only through these proceedings, but also through the
decision to continue the conference series with a second meeting to
be held in Berlin between September 17-21, 1991.
Over one hundred contributions detail advances in the molecular and
cellular biology of eicosanoid production, as well as their role in
signal transduction. One of the most exciting developments explored
within this collection of articles is the expression of the novel
isoform of cyclooxygenase (cox-2), which may play a large role in
the development of anti-inflammatory drugs.
th This volume contains selected lectures presented at the 12
International Conference on Advances in Prostaglandin, Leukotriene
and Other Bioactive Lipid Research: Basic Science and Clinical
Applications which was held in Istanbul, Turkey, on August 25-29,
2002. This meeting brought together basic and clinical scientists
for the purpose of discussing advances in bioactive lipid research
with.special attention to cancer, cardiovascular diseases,
gastrointestinal diseases and respiratory diseases. Topics covered
included: the role of leukotrienes and lipoxins in of inflammation,
the cytochrome P450 pathway, the genetics and genomics bioactive
lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes,
receptors and inhibitors, cyclooxygenase and lipoxygenase pathways
and inhibitors, prostaglandin synthases and receptor signaling,
phospholipases and inhibitors. Sessions included plenary lectures
with expertise in particular areas, oral presentation on selected
topics and general poster sessions. J.M. Drazen (Boston, USA)
discussed anti-leukotriene treatment in asthma patients while C.
Brink (paris, France) presented the recent advances in leukotriene
receptors. The recent advances in cytochrome p450 pathway described
in the session organized by J.C. McGiff (Valhalla, NY, USA). T.
Shimizu (Tokyo, Japan) and M. Balazy (Valhalla, NY, USA) gave an
update on phospholipases and arachidonic acid peroxydation. The
editors are greatful to the Organizing, Programme and Advisory
Committees for their valuable contributions. We greatfully
acknowledge the generous financial support provided by
PharmaciaIPfizer, Fako Pharmaceuticals Inc. and Novartis
Pharmaceuticals Inc. ofthe contributors to this volume, in
particular We are also greatful to all to those who delivered their
manuscripts by or before the requested deadline.
th This volume contains selected lectures presented at the 12
International Conference on Advances in Prostaglandin, Leukotriene
and Other Bioactive Lipid Research: Basic Science and Clinical
Applications which was held in Istanbul, Turkey, on August 25-29,
2002. This meeting brought together basic and clinical scientists
for the purpose of discussing advances in bioactive lipid research
with.special attention to cancer, cardiovascular diseases,
gastrointestinal diseases and respiratory diseases. Topics covered
included: the role of leukotrienes and lipoxins in of inflammation,
the cytochrome P450 pathway, the genetics and genomics bioactive
lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes,
receptors and inhibitors, cyclooxygenase and lipoxygenase pathways
and inhibitors, prostaglandin synthases and receptor signaling,
phospholipases and inhibitors. Sessions included plenary lectures
with expertise in particular areas, oral presentation on selected
topics and general poster sessions. J.M. Drazen (Boston, USA)
discussed anti-leukotriene treatment in asthma patients while C.
Brink (paris, France) presented the recent advances in leukotriene
receptors. The recent advances in cytochrome p450 pathway described
in the session organized by J.C. McGiff (Valhalla, NY, USA). T.
Shimizu (Tokyo, Japan) and M. Balazy (Valhalla, NY, USA) gave an
update on phospholipases and arachidonic acid peroxydation. The
editors are greatful to the Organizing, Programme and Advisory
Committees for their valuable contributions. We greatfully
acknowledge the generous financial support provided by
PharmaciaIPfizer, Fako Pharmaceuticals Inc. and Novartis
Pharmaceuticals Inc. ofthe contributors to this volume, in
particular We are also greatful to all to those who delivered their
manuscripts by or before the requested deadline.
This volume represents a collection of contributions from the 6th
International Conference on Eicosanoids and Other Bioactive Lipids
in Cancer, Inflammation, and Related Diseases held in Boston from
September 12-15, 1999. The mission of this meeting was to bring
together senior and junior investigators to both announce and
examine their recent advancements in cutting-edge research on the
roles and actions of lipid mediators and their impact in human
physiology and disease pathogenesis. The meeting focused on new
concepts in these areas of interest to both clinicians and
researchers. The program included several outstanding plenary
lectures and presentations by leading experts in the fields of
cancer and inflammation. In addition, the Boston meeting presented
three Young Investigator awards, one in each of the major focus
areas. The meeting was exciting and proved to be very memorable.
The program was developed with an emphasis on recent advances in
molecular and of lipid mediators relevant in cellular mechanisims
involved in the formation and actions inflammation and cancer.
Plenary lectures were presented by Prof. Bengt Sammuelsson
(Karolinska Institute, Stockholm; 1982 Nobel Laureate in Physiology
or Medicine) and Prof. E. 1. Corey (Harvard University; 1990 Nobel
Laureate in Chemistry). Both of these plenary lectures were held on
Day 1, which set an exciting tone for this meeting. Immediately
following these plenary lectures, three simultaneous breakout
sessions were held, one of inflammation, a second on cancer and
synthesis of novel inhibitors, and a third on
enzymes-lipoxygenases/cyclooxygenases and inhibitors.
Over one hundred contributions detail advances in the molecular and
cellular biology of eicosanoid production, as well as their role in
signal transduction. One of the most exciting developments explored
within this collection of articles is the expression of the novel
isoform of cyclooxygenase (cox-2), which may play a large role in
the development of anti-inflammatory drugs.
This volume constitutes, in part, the proceedings of the Hong Kong
Conference on "Eicosanoids and Other Bioactive Lipids in Cancer,
Inflammation, and Radiation Injury" held in Hong Kong in October
1995. It contains papers by the symposium speakers, as well as
poster contributions from researchers in this field. Since the
discovery of "PROSTAGLANDIN-LIKE' substances 60 years ago. much has
been learned. EICOSANOID is the new term that is used to include
prostaglandins. thromboxanes, leukotrienes, lipoxins, isoprostanes,
depoxilins, hydroxy acids, epoxy and hydroperoxy fatty acids. The
conference focussed on recent development in underatanding the role
of EICOSANOIDS in inflammation, cancer, and radiation damage. At
the confer- ence, we also highlighted advances in newly developing
areas such as "NO," "A POP- TOSIS and "ANANDAMIDE." The discovery
of the structures of genes that encode several key enzymes and
receptors of the Eicosanoid cascade, has allowed us to include
reports in the "Alteration of the Gene Expression" section that
reflects the most recent de- velopments in regulation for
PGH-synthase and lipoxygenases. The editors are convinced that this
volume will be an up-to-date and useful reference for investigators
in both basic and clinical research.
In the last decade, research on platelet-activating factor (PAF)
has expanded exponentially. Previous conferences on PAF in Paris,
1983, and the subsequent conferences in Gatlinburg, Ten nessee,
Tokyo, Snowbird, Utah, and Berlin, at three-yearly intervals, have
chronicled the devel opments in the field ofPAF. This volume
records the proceedings of the Fifth International Con gress on PAF
and Related Lipid Mediators, held at the Free University Medical
Hospital Ben jamin Franklin in Berlin, from September 12-16, 1995.
We are very much indebted to Free Uni versity Berlin for providing
tremendous facilities and financial support. It was a great
pleasure to have positive and generous input from the German
Science Council (DFG), Bonn, Germany, and British.Biotech, Oxford,
United Kingdom. Their support was crucial in making the congress a
scientific success. Twenty other organizations provided additional
financial support, for which we extend our deepest appreciation.
The editors would like to thank all of those who participated in
this congress and the authors for their contributions. The
organization and planning of the Berlin Congress were carried out
by an organizing committee. We gratefully acknowledge the support
and assistance of the organizing commit tee members, especially
Renate Nigam and Renate Roux for their untiring efforts to make the
congress successful. Many colleagues also supported the congress
with dedication, hard work, and expert input. We are grateful to
them. We also wish to acknowledge the support of G. Sravan Kumar
and Louis Kock for their efforts in producing this volume."
In recent decades eicosanoids have been attracting an increasing
amount of attention as a result of their important physiological
roles in many areas of biology and medicine. The eicosanoids
comprise the prostaglandins, thromboxanes and leukotrienes and are
products of arachidonic acid, an essential polyunsaturated fatty
acid stored in tissue phospholipids. Disturbances of eicosanoids
and their metabolic products play a regulatory role in many types
of cell injuries and diseases. One of the most exciting areas of
eicosanoid research pinpoints their participation in the control of
cell proliferation and differentiation. Eicosanoids form a link
between different fields of research into such areas as cancer,
inflammation and radiation-induced injury. This link provided the
impetus for the development of the conference series of which the
present volume represents the proceedings of the Second
International Conference, held in Berlin in October 1991.
This volume contains the proceedings of the First International
Conference on Eicosanoids and Other Bioactive Lipids in Cancer and
Radiation Injury held in Detroit, Michigan on October 11-14, 1989.
The program consisted of 83 oral and 29 poster presentations, 74 of
which are included in these proceedings. The major sponsors of the
conference were the Armed Forces Radiobiology Research Institute,
located in Bethesda, Maryland, the Radiation Oncology Research and
Development Center of the Gershenson Radiation Oncology Center,
Harper Hospital in Detroit, Michigan, and Schering AG of West
Germany. Eighteen other organizations provided additional support.
The conference was unique in its attempt to link the eicosanoid and
lipid researchers in the radiobiology and cancer disciplines. The
diverse roles that eicosanoids and other bioactive lipids play in
these biological phenomena including the participation of lipid
oxidation in conversion of procarcinogens, positive and negative
modulation of tumor growth, immunomodulation, tissue injury, and
yet protection and enhancement of cancer therapy, necessitated
scientific interaction to sort out and understand these complex and
sometimes contradictory observations. The success of this effort is
reflected not only through these proceedings, but also through the
decision to continue the conference series with a second meeting to
be held in Berlin between September 17-21, 1991.
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