-- This new edition offers significant new information, regarding new technologies like CRISPR-Cas, new housing systems and management practices (including metabolic cages), a table on injection volumes and recommended needle sizes, info on new concepts such as pain assessment by facial expression, possible anesthetic reversal agents, and the potential impact of common procedures on animal welfare. The regulatory section has been entirely updated. The book is now more relevant to an international audience, addressing differing regulations across borders. -- With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. These researchers and their lab technicians need a handy, quick and up-to-date reference guide to inform them of best practice when working with these animals. -- Unlike existing books on laboratory mice, this book focuses not only on veterinary medicine but also offers detailed information regarding management and behavior of mice. It also offers a concise synopsis of material relevant to those working with, and caring for, laboratory mice, making for an easily-used reference.