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This new volume looks at the applications of biomarkers as
important tools for herbal drug discovery, presenting research on
phytoconstituents with advanced nanotechnological applications for
healthcare benefits. Herbal drug discovery based on biomarkers is
an emerging area in complementary and alternative medicine that has
tremendous potential in healthcare. Conventional medications have
limited efficacy and high toxicity, whereas herbal drugs are said
to provide wide structural diversity that is not usually seen with
conventional/synthetic drug molecules. Recognition of various
herbal constituents, such as terpenoids, fatty acids, flavonoids
and steroids, are well explored in the management and treatment of
various disorders in this volume. These agents target various
biomarkers such as nitric oxide (NO), cytokines, chemokines,
adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic
acid. Biomarkers as Targeted Herbal Drug Discovery: A
Pharmacological Approach to Nanomedicines discusses
phytoconstituent-based nanotherapeutics with applications for some
specific health issues, such as arthritis, leishmanicidal,
cardiovascular diseases, cancer, ocular disorders, etc.
Reviews phyto-actives and their targeted action in the management
of various cancers Looks at the use of phytochemical-based
nano-cosmeceuticals for beautification Explores emerging concepts
of vitamins and nanocarriers as nutraceuticals Discusses the
advantages of bioactive-loaded nanomedicines over conventional
phytotherapies
This new volume looks at the applications of biomarkers as
important tools for herbal drug discovery, presenting research on
phytoconstituents with advanced nanotechnological applications for
healthcare benefits. Herbal drug discovery based on biomarkers is
an emerging area in complementary and alternative medicine that has
tremendous potential in healthcare. Conventional medications have
limited efficacy and high toxicity, whereas herbal drugs are said
to provide wide structural diversity that is not usually seen with
conventional/synthetic drug molecules. Recognition of various
herbal constituents, such as terpenoids, fatty acids, flavonoids
and steroids, are well explored in the management and treatment of
various disorders in this volume. These agents target various
biomarkers such as nitric oxide (NO), cytokines, chemokines,
adhesion molecules, NF- k , lipoxygenase (LOX), and arachidonic
acid. Biomarkers as Targeted Herbal Drug Discovery: A
Pharmacological Approach to Nanomedicines discusses
phytoconstituent-based nanotherapeutics with applications for some
specific health issues, such as arthritis, leishmanicidal,
cardiovascular diseases, cancer, ocular disorders, etc.
Pharmaceutical manufacturers are constantly facing quality crises
of drug products, leading to an escalating number of product
recalls and rejects. Due to the involvement of multiple factors,
the goal of achieving consistent product quality is always a great
challenge for pharmaceutical scientists. This volume addresses this
challenge by using the Quality by Design (QbD) concept, which was
instituted to focus on the systematic development of drug products
with predefined objectives to provide enhanced product and process
understanding. This volume presents and discusses the vital
precepts underlying the efficient, effective, and cost effective
development of pharmaceutical drug products. It focuses on the
adoption of systematic quality principles of pharmaceutical
development, which is imperative in achieving continuous
improvement in end-product quality and also leads to reducing cost,
time, and effort, while meeting regulatory requirements. The volume
covers the important new advances in the development of solid oral
dosage forms, modified release oral dosage forms, parenteral dosage
forms, semisolid dosage forms, transdermal drug, delivery systems,
inhalational dosage forms, ocular drug delivery systems,
nanopharmaceutical products, and nanoparticles for oral delivery.
Pharmaceutical manufacturers are constantly facing quality crises
of drug products, leading to an escalating number of product
recalls and rejects. Due to the involvement of multiple factors,
the goal of achieving consistent product quality is always a great
challenge for pharmaceutical scientists. This volume addresses this
challenge by using the Quality by Design (QbD) concept, which was
instituted to focus on the systematic development of drug products
with predefined objectives to provide enhanced product and process
understanding. This volume presents and discusses the vital
precepts underlying the efficient, effective, and cost effective
development of pharmaceutical drug products. It focuses on the
adoption of systematic quality principles of pharmaceutical
development, which is imperative in achieving continuous
improvement in end-product quality and also leads to reducing cost,
time, and effort, while meeting regulatory requirements. The volume
covers the important new advances in the development of solid oral
dosage forms, modified release oral dosage forms, parenteral dosage
forms, semisolid dosage forms, transdermal drug, delivery systems,
inhalational dosage forms, ocular drug delivery systems,
nanopharmaceutical products, and nanoparticles for oral delivery.
Nanotherapeutics in Cancer Vaccination and Challenges consolidates
the current research on cancer nanomedicine and therapeutic cancer
vaccination to explore the most effective and promising avenues.
The book covers cancer vaccines before exploring nanotherapeutics,
DNA and mRNA vaccines in cancer treatment. Finally, it considers
regulatory and industrial perspectives on cancer vaccination and
nanotherapeutics. This resource will be useful for pharmaceutical
scientists and researchers focused on biomedical engineering,
chemical engineering, vaccine development, and cancer
immunotherapy, along with advanced students in these subjects.
Cancer is arguably the most complex and challenging disease known
to mankind. Over the last two-decades, significant advancements
have been made in new and novel concepts of cancer nanomedicines.
Therapeutic cancer vaccines may be utilized to inhibit further
growth of advanced cancers and/or relapsed tumors that are
refractory to conventional therapies, such as surgery, radiation
therapy and chemotherapy.
This new volume, Nanomedicine for the Treatment of Disease: From
Concept to Application, looks at the application of nanomedicines
with a particular focus on their use in the treatment of diseases.
The chapters in this volume, contributed by eminent scientists,
researchers, and nanotechnologists from across the globe, highlight
key advancements, challenges, and opportunities in the area of
application of nanomedicines for disease treatment. They explore
the design and development of therapeutic nanocarriers for
targeting drugs for satiating the demands of disease treatment
process. The volume explores the use nanomedicines for the
diagnosis and treatment of a multitude various diseases and health
conditions, including respiratory diseases, neurological disorders,
genetic diseases, pulmonary fungal infections, neuroAIDS,
cardiovascular disorders, gastric and colonic diseases, skin
disorders, cancer, brain tumors, leishmaniasis and other visceral
diseases, hypertension, and ocular diseases.
This new volume, Nanomedicine for the Treatment of Disease: From
Concept to Application, looks at the application of nanomedicines
with a particular focus on their use in the treatment of diseases.
The chapters in this volume, contributed by eminent scientists,
researchers, and nanotechnologists from across the globe, highlight
key advancements, challenges, and opportunities in the area of
application of nanomedicines for disease treatment. They explore
the design and development of therapeutic nanocarriers for
targeting drugs for satiating the demands of disease treatment
process. The volume explores the use nanomedicines for the
diagnosis and treatment of a multitude various diseases and health
conditions, including respiratory diseases, neurological disorders,
genetic diseases, pulmonary fungal infections, neuroAIDS,
cardiovascular disorders, gastric and colonic diseases, skin
disorders, cancer, brain tumors, leishmaniasis and other visceral
diseases, hypertension, and ocular diseases.
This book volume provides complete and updated information on the
applications of Design of Experiments (DoE) and related
multivariate techniques at various stages of pharmaceutical product
development. It discusses the applications of experimental designs
that shall include oral, topical, transdermal, injectables
preparations, and beyond for nanopharmaceutical product
development, leading to dedicated case studies on various
pharmaceutical experiments through illustrations, art-works, tables
and figures. This book is a valuable guide for all academic and
industrial researchers, pharmaceutical and biomedical scientists,
undergraduate and postgraduate research scholars, pharmacists,
biostatisticians, biotechnologists, formulations and process
engineers, regulatory affairs and quality assurance personnel.
This book volume provides complete and updated information on the
applications of Design of Experiments (DoE) and related
multivariate techniques at various stages of pharmaceutical product
development. It discusses the applications of experimental designs
that shall include oral, topical, transdermal, injectables
preparations, and beyond for nanopharmaceutical product
development, leading to dedicated case studies on various
pharmaceutical experiments through illustrations, art-works, tables
and figures. This book is a valuable guide for all academic and
industrial researchers, pharmaceutical and biomedical scientists,
undergraduate and postgraduate research scholars, pharmacists,
biostatisticians, biotechnologists, formulations and process
engineers, regulatory affairs and quality assurance personnel.
Nanophytomedicine is a field that involves the application of
nanomedicine-based systems to phytotherapy and phytopharmacology.
This book assesses the clinical successes and failures of
nanophytomedicine and also highlights emerging concepts in this
field. The content is divided into three sections, the first of
which describes core issues in the pharmaceuticals industry in
connection with the successes, failures and prospects of
nanophytomedicine. The second section highlights recent advances in
phytomedicine formulation development based on nanotechnology
approaches, while also discussing a variety of nanocarrier systems
for the successful delivery of phytomedicines. Focusing on the
clinical perspective, the third section addresses the current
clinical status of nanophytomedicine as a single drug therapy or
combinatorial drug therapy, pharmacovigilance, pharmacokinetics,
drug interactions and toxicological profiles, while also providing
concluding remarks on recent experimental findings, and considering
ethical issues & regulatory challenges in nanophytomedicine.
Given its scope, the book offers a valuable guide for early career
researchers, young scientists, master level students, academics and
industrial scientists working in various healthcare fields, e.g.
the pharmaceutical and biological sciences, life sciences,
biotechnology, biomedical engineering, and nanobiotechnology.
This book volume provides complete and updated information on the
applications of Design of Experiments (DoE) and related
multivariate techniques at various stages of pharmaceutical product
development. It discusses the applications of experimental designs
that shall include oral, topical, transdermal, injectables
preparations, and beyond for nanopharmaceutical product
development, leading to dedicated case studies on various
pharmaceutical experiments through illustrations, art-works, tables
and figures. This book is a valuable guide for all academic and
industrial researchers, pharmaceutical and biomedical scientists,
undergraduate and postgraduate research scholars, pharmacists,
biostatisticians, biotechnologists, formulations and process
engineers, regulatory affairs and quality assurance personnel.
This book volume provides complete and updated information on the
applications of Design of Experiments (DoE) and related
multivariate techniques at various stages of pharmaceutical product
development. It discusses the applications of experimental designs
that shall include oral, topical, transdermal, injectables
preparations, and beyond for nanopharmaceutical product
development, leading to dedicated case studies on various
pharmaceutical experiments through illustrations, art-works, tables
and figures. This book is a valuable guide for all academic and
industrial researchers, pharmaceutical and biomedical scientists,
undergraduate and postgraduate research scholars, pharmacists,
biostatisticians, biotechnologists, formulations and process
engineers, regulatory affairs and quality assurance personnel.
Handbook of Analytical Quality by Design addresses the steps
involved in analytical method development and validation in an
effort to avoid quality crises in later stages. The AQbD approach
significantly enhances method performance and robustness which are
crucial during inter-laboratory studies and also affect the
analytical lifecycle of the developed method. Sections cover sample
preparation problems and the usefulness of the QbD concept
involving Quality Risk Management (QRM), Design of Experiments
(DoE) and Multivariate (MVT) Statistical Approaches to solve by
optimizing the developed method, along with validation for
different techniques like HPLC, UPLC, UFLC, LC-MS and
electrophoresis. This will be an ideal resource for graduate
students and professionals working in the pharmaceutical industry,
analytical chemistry, regulatory agencies, and those in related
academic fields.
Chitosan in Biomedical Applications provides a thorough insight
into the complete chitosan chemistry, collection, chemical
modifications, characterization and applications of chitosan in
biomedical applications and healthcare fields. Chitosan, a
biopolymer of natural origin, has been explored for its variety of
applications in biomedical research, medical diagnostic aids and
material science. It is the second most abundant natural biopolymer
after cellulose, and considered as an excellent excipient because
of its non-toxic, stable, biodegradable properties. Several
research innovations have been made on applications of chitosan in
biomedical applications. The book explores key topics, such as
molecular weight, degree of deacetylation, and molecular geometry,
along with an emphasis on recent advances in the field written by
academic, industry, and clinical researchers. Chitosan in
Biomedical Applications will be of interest to those in biomedical
fields including the biomaterials and tissue engineering community
investigating and developing biomaterials for biomedical
applications, particularly graduate students, young faculty and
others exploring chitosan-based materials.
Chitosan in Drug Delivery provides thorough insights into chitosan
chemistry, collection, chemical modifications, characterization and
applications in the pharmaceutical industry and healthcare fields.
The book explores molecular weight, degree of deacetylation and
molecular geometry, emphasizing recent advances in the field as
written by academic, industry and regulatory scientists. It will be
a useful resource for pharmaceutical scientists, including
industrial pharmacists, analytical scientists, postgraduate
students, health care professionals and regulatory scientists
actively involved in pharmaceutical product and process development
in natural polymers containing drug delivery.
The nanotheranostics sector provides a very promising strategy for
monitoring drug biodistribution and pathology longitudinal
processes by integrating the imaging and drug delivery functions in
one single nanoformulation, providing vital insights into the
identification of tumour and predicting the efficacy of
nanomedicine. For its unique properties, which include their small
size and biocompatibility and ability to permeate the cellular
membrane with carrying drugs, nanomaterials have been used for
various biomedical applications. This book covers the
progress made in hormone-related cancer and their management by
nonmedicinal therapy for targeting the hormone regulated cancer
with their clinical progress and clinical hurdles.
Nanophytomedicine is a field that involves the application of
nanomedicine-based systems to phytotherapy and phytopharmacology.
This book assesses the clinical successes and failures of
nanophytomedicine and also highlights emerging concepts in this
field. The content is divided into three sections, the first of
which describes core issues in the pharmaceuticals industry in
connection with the successes, failures and prospects of
nanophytomedicine. The second section highlights recent advances in
phytomedicine formulation development based on nanotechnology
approaches, while also discussing a variety of nanocarrier systems
for the successful delivery of phytomedicines. Focusing on the
clinical perspective, the third section addresses the current
clinical status of nanophytomedicine as a single drug therapy or
combinatorial drug therapy, pharmacovigilance, pharmacokinetics,
drug interactions and toxicological profiles, while also providing
concluding remarks on recent experimental findings, and considering
ethical issues & regulatory challenges in nanophytomedicine.
Given its scope, the book offers a valuable guide for early career
researchers, young scientists, master level students, academics and
industrial scientists working in various healthcare fields, e.g.
the pharmaceutical and biological sciences, life sciences,
biotechnology, biomedical engineering, and nanobiotechnology.
Nanoformulation Strategies for Cancer Treatment provides an
up-to-date review on current developments and regulatory and
clinical challenges in the field of nanopharmaceuticals and the
effective treatment of diverse varieties of cancer. This important
reference source is ideal for biomaterials scientists and
pharmaceutical scientists working in the area of cancer diagnosis
and therapy. Due to the high cost of traditional cancer treatment
types, researchers have increasingly looked for new ways to augment
the therapeutic performance of existing drug candidates. The use of
nanotechnology-based approaches have gained significant momentum,
thus leading to the launch of a series of new drug products. As
nanopharmaceuticals improve the therapeutic performance of cancer
therapy drugs, but also provide opportunities for site-specific
drug targeting in tumors, this work is a welcomed resource on the
topics discussed.
Pharmaceutical Quality by Design: Principles and Applications
discusses the Quality by Design (QbD) concept implemented by
regulatory agencies to ensure the development of a consistent and
high-quality pharmaceutical product that safely provides the
maximum therapeutic benefit to patients. The book walks readers
through the QbD framework by covering the fundamental principles of
QbD, the current regulatory requirements, and the applications of
QbD at various stages of pharmaceutical product development,
including drug substance and excipient development, analytical
development, formulation development, dissolution testing,
manufacturing, stability studies, bioequivalence testing, risk and
assessment, and clinical trials. Contributions from global leaders
in QbD provide specific insight in its application in a diversity
of pharmaceutical products, including nanopharmaceuticals,
biopharmaceuticals, and vaccines. The inclusion of illustrations,
practical examples, and case studies makes this book a useful
reference guide to pharmaceutical scientists and researchers who
are engaged in the formulation of various delivery systems and the
analysis of pharmaceutical product development and drug
manufacturing process.
Advances in technology permeates every aspect of life, including
the healthcare system. Nanotechnology based systems have gained
popularity based upon their promise, size, and other
characteristics. Multifunctional Nanocarriers for Contemporary
Healthcare Applications is a critical academic publication that
explores advancements in nanostructured systems, applications of
these systems in healthcare, and biomedical applications of these
systems. Featuring coverage on a wide range of topics, such as
hydrogels, controlled drug delivery systems, and nanomedicine, this
book is geared toward researchers, students, and academicians
seeking current research on advancements and applications of
nanostructured systems in the healthcare industry.
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