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Semisynthesis of Bioactive Compounds and their Biological
Activities explores the potential benefits of semisynthetic
derivatives obtained from nature. Sections cover the natural
distribution of parent compounds, semisynthesis and biological
properties of semisynthetic derivatives, the applications of
semisynthetic derivatives in diverse fields such as drug delivery,
food production and medicine, an explanation of the current
resistance mechanisms of antibiotics, clinical applications of
semisynthetic analogues, the functions of plant alkaloids on human
health, potential agricultural biotechnology in semisynthetic
derivatives, and semisynthesis of natural products under greener
conditions, this book provides a comprehensive resource on the
topics presented. Sections include information about alternative
sources of energy and superior greener technologies (microwave,
sonochemistry), alternative reaction media (water, supercritical
CO2, ionic liquids) and alternative eco-friendly catalysts
(biocatalysts). This book will be an excellent resource for
academicians, researchers and students focusing on synthesis as
well as the biological community and industry professionals in drug
development.
Modern Sustainable Techniques in Total Synthesis of Bioactive
Natural Products comprises five parts for green tools, such as
ultrasonic waves, microwave heating, visible-light photochemistry,
organic electrochemistry, and flow chemistry, along with 72
chapters for each bioactive molecule of natural origin. Each
chapter explores the natural source, structure, systematic name,
structural features, compound class, biological activity,
conventional approaches for their chemical synthesis, and
demerit(s) of conventional approaches (where applicable). Finally,
critical features of total synthesis using modern sustainable
techniques, including reaction types, synthetic strategy, and
synthetic route utilizing modern sustainable tools for each
bioactive natural product and secondary metabolites, are discussed
brilliantly. The spectrum of application of total synthesis of
bioactive natural products using modern sustainable techniques may
promote the development of more eco-friendly synthetic processes so
that the next generations can live on this planet with a minimum
energy requirement for chemical reactions with the least pollution.
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