Biopharmaceuticals are emerging as frontline medicines to combat several life-threatening and chronic diseases. However, such medicines are expensive to develop and produce on a commercial scale, contributing to rising healthcare costs. Developability of Biotherapeutics: Computational Approaches describes applications of computational and molecular modeling techniques that improve the overall process of discovery and development by removing empiricism. The concept of developability involves making rational choices at the pre-clinical stages of biopharmaceutical drug development that could positively impact clinical outcomes. The book also addresses a general lack of awareness of the many different contributions that computation can make to biopharmaceutical drug development. This informative and practical reference is a valuable resource for professionals engaged in industrial research and development, scientists working with regulatory agencies, and pharmacy, medicine, and life science students and educators. It focuses primarily on the developability of monoclonal antibody candidates, but the principles described can also be extended to other modalities such as recombinant proteins, fusion proteins, antibody drug conjugates and vaccines. The book is organized into two sections. The first discusses principles and applications of computational approaches toward discovering and developing biopharmaceutical drugs. The second presents best practices in developability assessments of early-stage biopharmaceutical drug candidates. In addition to raising awareness of the promise of computational research, this book also discusses solutions required to improve the success rate of translating biologic drug candidates into products available in the clinic. As such, it is a rich source of information on current principles and practices as well as a starting point for finding innovative applications of computation towards biopharmaceutical drug development.

This book presents selected research papers on current developments in the fields of computer vision and machine intelligence from International Conference on Computer Vision and Machine Intelligence (CVMI 2022). The book covers topics in image processing, artificial intelligence, machine learning, deep learning, computer vision, machine intelligence, etc. The book is useful for researchers, postgraduate and undergraduate students, and professionals working in this domain.

This three-volume set (CCIS 1367-1368) constitutes the refereed proceedings of the 5th International Conference on Computer Vision and Image Processing, CVIP 2020, held in Prayagraj, India, in December 2020. Due to the COVID-19 pandemic the conference was partially held online. The 134 papers papers were carefully reviewed and selected from 352 submissions. The papers present recent research on such topics as biometrics, forensics, content protection, image enhancement/super-resolution/restoration, motion and tracking, image or video retrieval, image, image/video processing for autonomous vehicles, video scene understanding, human-computer interaction, document image analysis, face, iris, emotion, sign language and gesture recognition, 3D image/video processing, action and event detection/recognition, medical image and video analysis, vision-based human GAIT analysis, remote sensing, and more.

This three-volume set (CCIS 1367-1368) constitutes the refereed proceedings of the 5th International Conference on Computer Vision and Image Processing, CVIP 2020, held in Prayagraj, India, in December 2020. Due to the COVID-19 pandemic the conference was partially held online. The 134 papers papers were carefully reviewed and selected from 352 submissions. The papers present recent research on such topics as biometrics, forensics, content protection, image enhancement/super-resolution/restoration, motion and tracking, image or video retrieval, image, image/video processing for autonomous vehicles, video scene understanding, human-computer interaction, document image analysis, face, iris, emotion, sign language and gesture recognition, 3D image/video processing, action and event detection/recognition, medical image and video analysis, vision-based human GAIT analysis, remote sensing, and more.

This three-volume set (CCIS 1376-1378) constitutes the refereed proceedings of the 5th International Conference on Computer Vision and Image Processing, CVIP 2020, held in Prayagraj, India, in December 2020. Due to the COVID-19 pandemic the conference was partially held online. The 134 papers papers were carefully reviewed and selected from 352 submissions. The papers present recent research on such topics as biometrics, forensics, content protection, image enhancement/super-resolution/restoration, motion and tracking, image or video retrieval, image, image/video processing for autonomous vehicles, video scene understanding, human-computer interaction, document image analysis, face, iris, emotion, sign language and gesture recognition, 3D image/video processing, action and event detection/recognition, medical image and video analysis, vision-based human GAIT analysis, remote sensing, and more.

Biopharmaceuticals are emerging as frontline medicines to combat several life-threatening and chronic diseases. However, such medicines are expensive to develop and produce on a commercial scale, contributing to rising healthcare costs. Developability of Biotherapeutics: Computational Approaches describes applications of computational and molecular modeling techniques that improve the overall process of discovery and development by removing empiricism. The concept of developability involves making rational choices at the pre-clinical stages of biopharmaceutical drug development that could positively impact clinical outcomes. The book also addresses a general lack of awareness of the many different contributions that computation can make to biopharmaceutical drug development. This informative and practical reference is a valuable resource for professionals engaged in industrial research and development, scientists working with regulatory agencies, and pharmacy, medicine, and life science students and educators. It focuses primarily on the developability of monoclonal antibody candidates, but the principles described can also be extended to other modalities such as recombinant proteins, fusion proteins, antibody drug conjugates and vaccines. The book is organized into two sections. The first discusses principles and applications of computational approaches toward discovering and developing biopharmaceutical drugs. The second presents best practices in developability assessments of early-stage biopharmaceutical drug candidates. In addition to raising awareness of the promise of computational research, this book also discusses solutions required to improve the success rate of translating biologic drug candidates into products available in the clinic. As such, it is a rich source of information on current principles and practices as well as a starting point for finding innovative applications of computation towards biopharmaceutical drug development.

This book is devoted to sewage sludge, its sustainable management, and its use and implications on soil fertility and crop production. The book traces the main chemical and biological properties of sewage sludge, and covers topics such as sewage sludge biostabilization and detoxification, biological and thermochemical treatment technologies, emerging nutrient recovery technologies, the role of microorganisms in sewage sludge management, and the sustainable use of sewage sludge as fertilizer in agriculture. The book offers a valuable asset for researchers, scholars and policymakers alike.

This book is devoted to sewage sludge, its sustainable management, and its use and implications on soil fertility and crop production. The book traces the main chemical and biological properties of sewage sludge, and covers topics such as sewage sludge biostabilization and detoxification, biological and thermochemical treatment technologies, emerging nutrient recovery technologies, the role of microorganisms in sewage sludge management, and the sustainable use of sewage sludge as fertilizer in agriculture. The book offers a valuable asset for researchers, scholars and policymakers alike.