This book is the proceedings of the Falk Symposium No. 137 on "Liver Diseases: Advances in Treatment and Prevention" (part of the XII International Falk Liver Week 2003 in honour of Hans Poppera (TM)s 100th birthday, held on October 17-19, 2003). It covers our present knowledge of the diagnosis, treatment and prevention of liver diseases, including hepatitis B, hepatitis C and delta hepatitis as well as alcoholic liver diseases, non-alcoholic steatohepatitis and the hereditary liver diseases haemochromatosis, Wilsona (TM)s disease and alpha-1-antitrypsin deficiency. In addition to these clinical entities, the sequelae of liver cirrhosis and its complications, including the clinical management of ascites, the hepatorenal as well as the hepato- and porto-pulmonary hypertension syndrome are discussed. New developments with respect to liver support systems and liver transplantation are further highlights of the proceedings.

The main topics mentioned above are complemented by state-of-the-art chapters on "Hepatocellular Carcinoma," "Emerging Hepatitis Viruses" and "Fulminant Liver Failure" that are of interest to both basic scientists as well as clinicians. A special section is devoted to "Liver Histology" as a tribute to Hans Popper who contributed eminently to the basic and clinical aspects of hepatology.

All in all, Liver Diseases: Advances in Treatment and Prevention provides an exciting overview of the current developments in the treatment and prevention of viral, alcoholic, non-alcoholic and hereditary liver diseases, presented by an international faculty of outstanding scientists and clinicians.

The beginning of a new millennium is an ideal opportunity to look back, to contemplate the present and to envisage what the future might have to offer. This seems particularly appropriate for the rapidly developing field of hepatology. Therefore, the aim of the Falk Symposium 117, Hepatology 2000, held in Munich on 4-6 May 2000, was to offer state-of-the-art information on the most important aspects of hepatology and to discuss the challenges of the future. The presentations were given by experts in their respective areas, providing an update and at the same time incorporating the most recent developments. These proceedings, a tour d'horizon of hepatology at the highest clinical and scientific level, is dedicated to Gustav Paumgartner who has retired from his duties as chairman of the Department of Medicine II at the University of Munich- Grosshadern. The scientific organisers take this opportunity to thank their academic teacher and to honour his lifelong engagement and achievements in hepatology. This book is cordially dedicated to him.

Liver cirrhosis is a major clinical problem worldwide and is associated with significant morbidity and mortality from its complications, such as liver cell insufficiency with coagulopathy and hepatic encephalopathy, portal hypertension with ascites and gastrointestinal bleeding, hepatorenal syndrome, HCC development and others. This volume, the proceedings of Falk Symposium 115 held in Basel, Switzerland, October 22-24, 1999 (Part II of the Basel Liver Week 1999; XI International Congress of Liver Diseases) covers our present knowledge of the aetiologies and early stages of liver cirrhosis development. Based on this information, strategies are discussed that are aimed at the prevention, early diagnosis and therapy of chronic liver diseases, thus preventing their progression to cirrhosis and its complications, including HCC development. The main topics mentioned above are complemented by three state-of-the-art chapters on modern aspects of medicine in general and hepatology in particular as well as their perspectives beyond the year 2000: `Molecular Medicine', `New Hepatitis Viruses' and `Genetic Liver Diseases: Diagnosis and Therapy'. Introductory chapters focusing on the more basic aspects of the biology of live cells as well as on the mechanisms underlying fibrogenesis, cholestasis and inflammation will be followed by a detailed discussion of the clinically most important causes of liver cirrhosis worldwide: hepatitis viruses B, C and D; toxins (alcohol, drugs and others) as well as metabolic liver diseases (haemochromatosis, Wilson disease, alpha-1-antitrypsin deficiency, porphyria cutanea tarda and protoporphyria). This book, therefore, will interest clinically oriented basic scientists as well as those in clinical practice, givng an update on many aspects of modern hepatology and its perspectives in the next millennium.

This book is the proceedings of Falk Symposium 157, entitled ?Chronic Hepatitis: Metabolic, Cholestatic, Viral and Autoimmune?, held in Freiburg, Germany, on 10--11 October 2006 (one of three symposia during the XIII Falk Liver Week 2006). It provides up-to-date information on new developments in the field of chronic hepatitis and its various entities. In recent decades we have learned how heterogeneous the clinical entity of chronic hepatitis has become. The liver, as the central organ of metabolism and detoxification, is more than ever a target of disease processes evolving from the spread of obesity in the western world. Apart from nonalcoholic steatohepatitis (NASH), alcoholic liver disease is still the most prevalent liver disease in the west...

Constant change is what marks the history of the European city. Over centuries, architecture's reactions to social disruptions-natural disaster, plague, or war-have fashioned the city into an engine of civilization. And bound up with this has been the promise of economic independence, social cohesion, and individual freedom. Now fundamental challenges, such as climate change, are bringing cities face to face with new transformations that call into question the continuity and sustainability of the ethical foundations underpinning urban ways of life. Bold and decisive steps are needed. How far can urban planning, landscape planning, and architecture foster the vital processes of change? How can the city offset possible losses caused by altered lifestyles, integrate new technologies, or rehearse new forms of behaviour and ultimately sublimate them into a functioning culture? In this volume, the members of the Architecture Section of the Akademie der Kunste Berlin and their invited guests from all over Europe introduce their positions by means of projects, visions, and manifestos. Essays by selected authors with different viewpoints supplement the practical discourse. Published by Tim Rieniets, Matthias Sauerbruch, and Joern Walter on behalf of the Akademie der Kunste, Berlin. With a photoessay by Erik-Jan Ouwerkerk.

Following the pair of monographic "Sauerbruch Hutton Archives" (Archive, 2006; Archive 2, 2016) Lars Mu ller Publishers presents a reader edited by the architects. Matthias Sauerbruch and Louisa Hutton have asked a diverse group of authors to reflect on the various conditions that have shaped the conception, production and dissemination of architecture in Europe over the course of the last three decades, and of the architecture that has resulted. The essays generally include observations on one or more of Sauerbruch Hutton's buildings, but these do not necessarily form the focus of the respective texts. The authors include critics who have written on the work of the practice in the past, architectural colleagues and writers whose opinions and observations are respected by the editors as well as a handful of people who either live or work in one of their buildings and so have experienced Sauerbruch Hutton's architecture firsthand. Further, a photographic essay by the Finnish artist Ola Kolehmainen will augment the twenty-fi ve essays with works created between 1990 and 2020. Analogous to the written pieces, these are images in their own right and of their own subjects that have been triggered by the presence of one of Sauerbruch Hutton's buildings.

"The current compendium traces the development of the office's architectural practice and thinking through a series of completed buildings, works in progress and projects that, as yet, remain unrealised. The book illuminates its strategies of sustainable design, its multiple interventions in the post-industrial cityscape and the unfolding of an architectural language full of sense and sensuality that reacts to its physical and social context, as well as to functional, technical, spatial and sculptural considerations. The book reveals Sauerbruch and Hutton's understanding of their profession as an ongoing process of research into presence and future, and is the only comprehensive documentation of their numerous works."

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfangen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen fur die historische wie auch die disziplingeschichtliche Forschung zur Verfugung, die jeweils im historischen Kontext betrachtet werden mussen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Florens Sauerbruch untersucht, welche Funktionen das Beschlussmangelrecht im Kontrollgefuge der Aktiengesellschaft erfullt. Er analysiert die Anreizstrukturen, die missbrauchliche Klagen begunstigen und erlautert die Wirkungsweise des Freigabeverfahrens und gibt Auslegungsempfehlungen fur die Tatbestandsmerkmale des Paragraphen und entwickelt Vorschlage zur weiteren Reform des Aktiengesetzes."

Die Geschichte der europaischen Stadt ist durch standigen Wandel gepragt. Bauliche Reaktionen auf gesellschaftliche Bruche, verursacht durch Naturkatastrophen, Seuchen oder Kriege, haben die Stadt in Europa durch die Jahrhunderte zum Zivilisationsmotor entwickelt. Damit einher ging das Versprechen von wirtschaftlicher Unabhangigkeit, sozialem Zusammenhalt und individueller Freiheit. Fundamentale Herausforderungen wie der Klimawandel konfrontieren Stadte heute mit Veranderungen, die die Kontinuitat und Nachhaltigkeit der ethischen Grundlagen stadtischer Lebensformen in Frage stellen. Mutige und entschlossene Schritte sind erforderlich. Inwieweit koennen Massnahmen des Stadtebaus, der Landschaftsplanung und der Architektur die notwendigen Veranderungsprozesse befoerdern? Wie koennen in der Stadt etwaige mit der Umstellung von Lebensstilen verbundene Verluste kompensiert, neue Technologien integriert, neue Verhaltensformen eingeubt und letztlich zu einer funktionierenden Kultur sublimiert werden? Die Mitglieder der Sektion Baukunst der Akademie der Kunste, Berlin und ihre eingeladenen Gaste aus ganz Europa stellen anhand von Projekten, Visionen und Manifesten ihre Positionen vor. Essays ausgewahlter Autorinnen und Autoren erganzen den praktischen Diskurs aus unterschiedlichen Blickwinkeln. Herausgegeben von Tim Rieniets, Matthias Sauerbruch und Joern Walter im Auftrag der Akademie der Kunste, Berlin. Mit einem Fotoessay von Erik-Jan Ouwerkerk.

Die Arbeit, die wir Arzten und Technikern iibergeben, ist nur ein Entwurl und darum nicht abgeschlossen. Die Herstellung einer will kiirlich bewegbaren, kiinstlichen Hand ist bisher an einer Reihe tech nischer Schwierigkeiten gescheitert. Nur der chirurgische Teil der Aufgabe hat einen gewissen AbschluB erreicht. Die anatomisch-physiologischen und klinischen Grundlagen, auf denen die Arbeit des Chirurgen beruht, sind in den Hauptziigen sichergestellt. Trotzdem darl man Erganzungen erwarten. Dasselbe gilt fiir die chirurgische Methodik. Jedenfalls ist aber der Beweis er bracht, daB die Muskelkraft eines Amputationsstumpfes erlolgreich fiir nahezu gleichwertige Leistung der physiologischen Arbeit herangezogen werden kann. Die Herausgabe des Buches vor Erreichung des gesteckten Zieles war notwendig. Viele Anfragen und zahlreiche Besuche von Chirurgen im Vereinslazarett zu Singen drangten dazu. Auch der Techniker bedarl fiir seine konstruktiven Aufgaben einer genauen Kenntnis der chirurgischen Vorarbeit. Noch wichtiger ist fiir ihn der Inhalt des anatomischen Teiles; er ist darum umfangreicher geworden. Die allgemein -chirurgischen technischen Ausfiihrungen beschranken sich auf Angaben der wichtigsten Richtlinien fiir die Arbeit des Tech nikers yom Standpunkt des Arztes. Eine ausfiihrliche Behandlung der technischen Aufgabe durch einen geeigneten Fachmann ist fiir die nachste Zukunft in Aussicht genommen."

Dieses Kompendium bietet einen neuen Einblick in das Werk von sauerbruch hutton: Die Entwicklung ihres architektonischen Denkes lAsst sich lA1/4ckenlos nachverfolgen anhand von den Texten der Architekten, anhand der beachtlichen Anzahl nicht umgesetzter EntwA1/4rfe sowie anhand von realisierten oder im Bau befindlichen Projekten, wie z.B. der GSW Hauptverwaltung in Berlin, dem Umweltbundesamt in Dessau oder dem Museum fA1/4r die Sammlung Brandhorst in MA1/4nchen. Das Buch gibt einerseits einen weitreichenden Aoeberblick, macht aber andererseits auch verstAndlich, wie jedes Projekt individuell aus dem baulichen und sozialen Kontext heraus entwickelt wurde, und die jeweiligen Formen aus funktionalen, technischen, rAumlichen und skulpturalen Aoeberlegungen entstehen.

Das Buch lAsst erkennen, wie sauerbruch hutton ihre Arbeit als einen Prozess kontinuierlicher Forschung verstehen. Dabei taucht der Schwerpunkt der Nachhaltigkeit im gesamten Buch immer wieder als wesentlicher Bestandteil ihres Interesses auf. DarA1/4berhinaus haben die Architekten eine eigene Sprache entwickelt, die am rAumlichen Einsatz von Farbe und Material sowie ihrer organischen KArperlichkeit wieder erkennbar ist.