This volume constitutes the proceedings of the 18th International Conference on Intelligent Tutoring Systems, ITS 2022, held in Bucharest, Romania, in June 2022. The 14 full papers, 13 short papers and 11 poster papers presented in this volume were carefully reviewed and selected from 50 submissions. The papers are categorized into the following topical sub-headings: Tools and Methods for learning Sciences and Practices; Algorithms for Prediction, Recommendation and Classification in Learning Systems; Tutoring and Learning Systems: New Approaches, Framework and Theories.