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The current resurgence of tuberculosis (TB) is being sustained and
fuelled by the increasing incidence of resistance of M tuberculosis
strains to the most-effective (first-line) anti-TB drugs and
association of active TB disease with concomitant human
immunodeficiency virus (HIV) infection or other underlying
immunosuppressive conditions such as diabetes. In this book, the
authors study the risk factors, drug resistance data and treatment
methods for tuberculosis. Topics discussed include the global
burden of TB and its public health crisis; new medicines to treat
TB; rapid microcalorimetric detection of TB; meta-analysis and risk
factors for tuberculosis susceptibility; Type 2 diabetes as a risk
factor for TB; and elucidating the action mode of the bi-substrate
InhA inhibitors as anti-tuberculosis agents through molecular
dynamics simulations.
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