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DNA and RNA extraction methods from a variety of tissues and
samples are now routine, including extraction from single cells.
Many methods are now automated. Sequencing efficiency has reached
the point where it is now possible to obtain gigabases of data,
both quickly and inexpensively. Such methods permit the
identification of gene versions, including those associated with
disease (e.g. small nucleotide polymorphism analyses, or SNPs). The
general public as well as clinicians can now access a wide variety
of literature on the molecular bases of diseases, allowing them to
better assess disease risks and treatments. This volume
concentrates on medically-focused methods, and therefore the major
audience will be medical professionals, students, and those
involved in medically-related research endeavors. There are also
papers in this volume dealing specifically with methods developed
to analyze large sequence data sets. Many methods reviewed herein
are more broadly applicable to other fields in biology, chemistry,
bioinformatics, and bioengineering, and are intended for a broad
readership. Key Features Summarizes nucleic acid extractions from a
wide variety of tissues and cells Describes processes of nucleic
acid preservation Reviews forensic sampling, detection of nucleic
acids, and delivery of nucleic acids to multicellular organisms
Provides essential guidance for sequencing, sequence analysis,
database searches, and phylogenetic analyses Includes additional
methods useful for analysis of nucleic acids and proteins Related
Titles DeSalle, et al. Phylogenomics: A Primer (ISBN
978-0-3670-2849-7). Jennings, W. B. Phylogenomic Data Acquisition:
Principles and Practice (ISBN 978-0-3678-6980-9). Wang, X.
Next-Generation Sequencing Data Analysis (ISBN 978-1-4822-1788-9)
Sung, W.-K. Algorithms for Next-Generation Sequencing (ISBN
978-0-3676-5797-0)
Evolutionary biology has increasingly relied upon tools developed
in molecular biology that allow for the structure and function of
macromolecules to be used as data for exploring the patterns and
processes of evolutionary change. Integrated Molecular Evolution,
Second Edition is a textbook intended to expansively and
comprehensive review evolutionary studies now routinely using
molecular data. This new edition has been thoroughly updated and
expanded, and provides a basic summary of evolutionary biology as
well as a review of current phylogenetics and phylogenomics.
Reflecting a burgeoning pedagogical landscape, this new edition
includes nearly double the number of chapters, including a new
section on molecular and bioinformatic methods. Dedicated chapters
were added on: Evolution of the genetic code Mendelian genetics and
population genetics Natural selection Horizontal gene transfers
Animal development and plant development Cancer Extraction of
biological molecules Analytical methods Sequencing methods and
sequencing analyses Omics Phylogenetics and phylogenetic networks
Protein trafficking Human genomics More than 400 illustrations
appear in this edition, doubling the number included in the first
edition, and over 100 of these diagrams are now in color. The
second edition combines and integrates extensive summaries of
genetics and evolutionary biology in a manner that is accessible
for students at either the graduate or undergraduate level. It also
provides both the basic foundations of molecular evolution, such as
the structure and function of DNA, RNA and proteins, as well as
more advanced chapters reviewing analytical techniques for
obtaining sequences, and interpreting and archiving molecular and
genomic data.
Evolutionary biology has increasingly relied upon tools developed
in molecular biology that allow for the structure and function of
macromolecules to be used as data for exploring the patterns and
processes of evolutionary change. Integrated Molecular Evolution,
Second Edition is a textbook intended to expansively and
comprehensive review evolutionary studies now routinely using
molecular data. This new edition has been thoroughly updated and
expanded, and provides a basic summary of evolutionary biology as
well as a review of current phylogenetics and phylogenomics.
Reflecting a burgeoning pedagogical landscape, this new edition
includes nearly double the number of chapters, including a new
section on molecular and bioinformatic methods. Dedicated chapters
were added on: Evolution of the genetic code Mendelian genetics and
population genetics Natural selection Horizontal gene transfers
Animal development and plant development Cancer Extraction of
biological molecules Analytical methods Sequencing methods and
sequencing analyses Omics Phylogenetics and phylogenetic networks
Protein trafficking Human genomics More than 400 illustrations
appear in this edition, doubling the number included in the first
edition, and over 100 of these diagrams are now in color. The
second edition combines and integrates extensive summaries of
genetics and evolutionary biology in a manner that is accessible
for students at either the graduate or undergraduate level. It also
provides both the basic foundations of molecular evolution, such as
the structure and function of DNA, RNA and proteins, as well as
more advanced chapters reviewing analytical techniques for
obtaining sequences, and interpreting and archiving molecular and
genomic data.
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