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This volume expands on statistical analysis of genomic data by
discussing cross-cutting groundwork material, public data
repositories, common applications, and representative tools for
operating on genomic data. Statistical Genomics: Methods and
Protocols is divided into four sections. The first section
discusses overview material and resources that can be applied
across topics mentioned throughout the book. The second section
covers prominent public repositories for genomic data. The third
section presents several different biological applications of
statistical genomics, and the fourth section highlights software
tools that can be used to facilitate ad-hoc analysis and data
integration. Written in the highly successful Methods in Molecular
Biology series format, chapters include introductions to their
respective topics, step-by-step, readily reproducible analysis
protocols, and tips on troubleshooting and avoiding known pitfalls.
Through and practical, Statistical Genomics: Methods and Protocols,
explores a range of both applications and tools and is ideal for
anyone interested in the statistical analysis of genomic data.
This volume expands on statistical analysis of genomic data by
discussing cross-cutting groundwork material, public data
repositories, common applications, and representative tools for
operating on genomic data. Statistical Genomics: Methods and
Protocols is divided into four sections. The first section
discusses overview material and resources that can be applied
across topics mentioned throughout the book. The second section
covers prominent public repositories for genomic data. The third
section presents several different biological applications of
statistical genomics, and the fourth section highlights software
tools that can be used to facilitate ad-hoc analysis and data
integration. Written in the highly successful Methods in Molecular
Biology series format, chapters include introductions to their
respective topics, step-by-step, readily reproducible analysis
protocols, and tips on troubleshooting and avoiding known pitfalls.
Through and practical, Statistical Genomics: Methods and Protocols,
explores a range of both applications and tools and is ideal for
anyone interested in the statistical analysis of genomic data.
This text offers an examination of Welsh military organization,
strategy, tactics and conduct in war which goes beyond the military
sphere and touches on all aspects of Welsh society in this period.
It helps to explain the transformation of the country from a part
of post-Roman medieval Europe to the series of independent
principalities eventually conquered by Edward I. The author
questions many of the traditional assumptions, notably the tendency
to see the Welsh (and the Irish and the Scottish) as "barbaric" and
provides a corrective to these current views. It demonstrates that,
whilst allowing for differences given the nature, economy,
geography and topography of the country, Welsh military
developments from the end of Roman rule to the Edwardian conquest
generally correspond to those seen in the rest of Western Europe.
This book highlights the historic inflection point we are in, both
in terms of philanthropy in general, and specifically in financing
the solutions to our largest and most urgent social and
environmental problems. It covers the two movements that have
recently had a dramatic influence on capitalism. First, wealthy
millennials have been pressuring their bankers to invest their
family portfolios in companies with high social and environmental
impact (ESG ratings), triggering a wave where the wealth management
industry, and now all public companies, are significantly adapting
to the increasing demand for good. Second, The Giving Pledge
triggered another wave, changing what success and the accumulation
of wealth means. It has even begun to redefine the goal of
capitalism as more than 200 billionaires have pledged to give half
or more of their wealth away. This book also focuses on the
bottleneck problem that The Giving Pledge has created, as it is
very hard to give hundreds of billions away with measurable impact
to nonprofits lacking detailed long-term plans to scale. Nonprofits
have never had the luxury of having all the resources to invest in
the planning, management training and systems needed to rapidly
expand. Thus taking in very large gifts is very difficult, and
almost impossible to justify. Large philanthropy can always be used
for traditional capital campaigns and to fund endowments, yet The
Giving Pledge signers are often looking for large visible impact
beyond these traditional avenues. The result is a bottleneck which
has grown as more billionaires pledge their funds away while their
wealth continues to skyrocket and giving rates stay very small.
Finally, this book covers the emergence of large giving vehicles,
modelled after the private equity industry. They have sophisticated
third-party managers focused on deploying funds and supporting
management teams. It also covers the scaling of nonprofits in a
significant way ("Big Bets") as well as investing large
philanthropy through for-profits as Program Related Investments
(PRI) at scale. This book is of interest specifically to nonprofit
and foundation leaders, as well as wealth managers, estate
attorneys and other philanthropic advisors. It is also of interest
to investors and corporate CEOs as they begin to access these large
pools for philanthropic capital to increase their impact. This book
is focused on providing those with the ability to make large
philanthropic investments a path to scale their impact and increase
their fulfillment and that of their family. It provides a
step-by-step guide of how these approaches, especially PRI at
scale, can actually solve the social and environmental challenges
that have been seemingly hopeless.
This book highlights the historic inflection point we are in, both
in terms of philanthropy in general, and specifically in financing
the solutions to our largest and most urgent social and
environmental problems. It covers the two movements that have
recently had a dramatic influence on capitalism. First, wealthy
millennials have been pressuring their bankers to invest their
family portfolios in companies with high social and environmental
impact (ESG ratings), triggering a wave where the wealth management
industry, and now all public companies, are significantly adapting
to the increasing demand for good. Second, The Giving Pledge
triggered another wave, changing what success and the accumulation
of wealth means. It has even begun to redefine the goal of
capitalism as more than 200 billionaires have pledged to give half
or more of their wealth away. This book also focuses on the
bottleneck problem that The Giving Pledge has created, as it is
very hard to give hundreds of billions away with measurable impact
to nonprofits lacking detailed long-term plans to scale. Nonprofits
have never had the luxury of having all the resources to invest in
the planning, management training and systems needed to rapidly
expand. Thus taking in very large gifts is very difficult, and
almost impossible to justify. Large philanthropy can always be used
for traditional capital campaigns and to fund endowments, yet The
Giving Pledge signers are often looking for large visible impact
beyond these traditional avenues. The result is a bottleneck which
has grown as more billionaires pledge their funds away while their
wealth continues to skyrocket and giving rates stay very small.
Finally, this book covers the emergence of large giving vehicles,
modelled after the private equity industry. They have sophisticated
third-party managers focused on deploying funds and supporting
management teams. It also covers the scaling of nonprofits in a
significant way ("Big Bets") as well as investing large
philanthropy through for-profits as Program Related Investments
(PRI) at scale. This book is of interest specifically to nonprofit
and foundation leaders, as well as wealth managers, estate
attorneys and other philanthropic advisors. It is also of interest
to investors and corporate CEOs as they begin to access these large
pools for philanthropic capital to increase their impact. This book
is focused on providing those with the ability to make large
philanthropic investments a path to scale their impact and increase
their fulfillment and that of their family. It provides a
step-by-step guide of how these approaches, especially PRI at
scale, can actually solve the social and environmental challenges
that have been seemingly hopeless.
This is the first book on one of Wales's greatest leaders, arguably
'first prince of Wales', Bleddyn ap Cynfyn. Bleddyn was at the
heart of the tumultuous events that forged Britain in the cauldron
of Norman aggression, and his reign offers an important new
perspective on the events of 1066 and beyond. He was a leader who
used alliances on the wider British scale as he strove to recreate
the fledgling kingdom of Wales that had been built and ruled by his
brother, though outside pressures and internal intrigues meant his
successors would compete ultimately for a principality.
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Tattered (Paperback)
Sean Davis, Kate Davis Poetry; Kate Davis Poetry
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R272
Discovery Miles 2 720
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Ships in 10 - 15 working days
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Gruffudd ap Llywelyn was Wales’ greatest king. Ambitious and
battle-sure, he succeeded in doing what no Welsh king before him
was capable of: he ruled all Wales as a united and independent
state. He went further by turning the Viking threat to his realm
into a powerful weapon and conquering border land that had been in
English hands for centuries. Having emerged as a war leader,
Gruffudd also proved to be much more: a patron of the arts and
church, with the trappings of a king who was respected and feared
on the European stage. His eventual murder at the hands of his own
men narrowed the country’s political ambitions and left Wales in
chaos on the eve of the arrival of the Normans. Those who betrayed
Gruffudd were the forebears of the famous princes who would
dominate Wales until the Edwardian Conquest, meaning that the
former king left no one to tell of his glory. As a result, 1,000
years after his birth, the would-be nation builder is all but
forgotten. Here, Sean and Michael Davies reveal the king in all his
glory, telling for the first time the story of one of Wales’
greatest figures and exploring the full implications of
Gruffudd’s rule. For, without Gruffudd, the fate of King Harold
and the outcome of the Battle of Hastings would have been very
different…
Edward I s conquest of Wales was a key formative event in the
history of Britain, but it has not been the subject of a scholarly
book for over 100 years. Research has advanced since then, changing
our perception of the medieval military mind and shining fresh
light on the key characters involved in the conquest. That is why
Sean Davies s absorbing new study is so timely and important. He
takes a balanced approach, giving both the Welsh and English
perspectives on the war and on the brutal, mistrustful and ruthless
personal motives that drove events. His account is set in the
context of Welsh warfare and society from the end of Rome to the
time of Edward s opening campaign in the late thirteenth century.
The narrative describes in vivid detail the military history of the
conflict, the sequence of campaigns, Welsh resistance, Edward s
castle building and English colonization and the cost of the
struggle to the Welsh and the English and the uneasy peace that
followed.
On September 12, 2001, a year and a half after finishing his
military service, Sean Davis strolled into the Oregon National
Guard's recruiting office and re-enlisted. After dropping out of
art school and working a dead-end government job, September 11 gave
him a new sense of purpose and direction. Follow Sean Davis' life
as he discovers the oddities of a pop-up America in a hostile
desert wasteland; loses his best friend in a violent ambush;
returns, critically wounded, to confinement in a place that's not
his home; deals with the fallout of PTSD and the horror of what he
experienced in that war zone; and finally, as he rediscovers art
and its power to heal.
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