This volume expands on statistical analysis of genomic data by discussing cross-cutting groundwork material, public data repositories, common applications, and representative tools for operating on genomic data. Statistical Genomics: Methods and Protocols is divided into four sections. The first section discusses overview material and resources that can be applied across topics mentioned throughout the book. The second section covers prominent public repositories for genomic data. The third section presents several different biological applications of statistical genomics, and the fourth section highlights software tools that can be used to facilitate ad-hoc analysis and data integration. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible analysis protocols, and tips on troubleshooting and avoiding known pitfalls. Through and practical, Statistical Genomics: Methods and Protocols, explores a range of both applications and tools and is ideal for anyone interested in the statistical analysis of genomic data.

This volume expands on statistical analysis of genomic data by discussing cross-cutting groundwork material, public data repositories, common applications, and representative tools for operating on genomic data. Statistical Genomics: Methods and Protocols is divided into four sections. The first section discusses overview material and resources that can be applied across topics mentioned throughout the book. The second section covers prominent public repositories for genomic data. The third section presents several different biological applications of statistical genomics, and the fourth section highlights software tools that can be used to facilitate ad-hoc analysis and data integration. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible analysis protocols, and tips on troubleshooting and avoiding known pitfalls. Through and practical, Statistical Genomics: Methods and Protocols, explores a range of both applications and tools and is ideal for anyone interested in the statistical analysis of genomic data.

A pragmatic, clinical approach focuses on the essential knowledge needed for the successful practice of family therapy The Essentials of Family Therapy examines the full scope of family therapy - its rich history, classic schools, and latest developments - with an increased emphasis on practical issues. With its focus on contemporary clinical practice, illustrative case studies, and extremely practical presentation, The Essentials of Family Therapy helps readers gain a thorough understanding of why a therapy technique is successful and how they can apply it in their own practice. The 7th Edition features new case studies with Reflect and Apply Questions to help students think about how to apply therapeutic principles; end-of chapter questions that are designed to help readers think critically about the principles in the chapter and consider how to apply them; and additional content highlighting the essential concepts in each chapter. New material that emphasizes recent trends in clinical practice has been added, including: a revised Cognitive-Behavioral chapter that focuses on recent trends (Ch.9); a new section on families with transgender members (Ch. 10); and a new chapter about research (Ch. 14). Also available with MyLab Helping Professions By combining trusted author content with digital tools and a flexible platform, MyLab personalizes the learning experience and improves results for each student. MyLab Helping Professions organizes all assignments around the CSWE EPAS for Social Work and CSHSE Standards for Human Services - enabling easy course alignment and reporting. MyLab Helping Professions for Family Therapy also includes mapping to the COAMFTE Standards. Note: You are purchasing a standalone product; MyLab does not come packaged with this content. Students, if interested in purchasing this title with MyLab Education, ask your instructor to confirm the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and MyLab Helping Professions, search for: 0135167795 / 9780135167793 The Essentials of Family Therapy Plus MyLab Helping Professions with Pearson eText -- Access Card Package Package consists of: 0135168090 / 9780135168097 The Essentials of Family Therapy 0135223946 / 9780135223949 MyLab Helping Professions with Pearson eText -- Access Card -- for The Essentials of Family Therapy

This book highlights the historic inflection point we are in, both in terms of philanthropy in general, and specifically in financing the solutions to our largest and most urgent social and environmental problems. It covers the two movements that have recently had a dramatic influence on capitalism. First, wealthy millennials have been pressuring their bankers to invest their family portfolios in companies with high social and environmental impact (ESG ratings), triggering a wave where the wealth management industry, and now all public companies, are significantly adapting to the increasing demand for good. Second, The Giving Pledge triggered another wave, changing what success and the accumulation of wealth means. It has even begun to redefine the goal of capitalism as more than 200 billionaires have pledged to give half or more of their wealth away. This book also focuses on the bottleneck problem that The Giving Pledge has created, as it is very hard to give hundreds of billions away with measurable impact to nonprofits lacking detailed long-term plans to scale. Nonprofits have never had the luxury of having all the resources to invest in the planning, management training and systems needed to rapidly expand. Thus taking in very large gifts is very difficult, and almost impossible to justify. Large philanthropy can always be used for traditional capital campaigns and to fund endowments, yet The Giving Pledge signers are often looking for large visible impact beyond these traditional avenues. The result is a bottleneck which has grown as more billionaires pledge their funds away while their wealth continues to skyrocket and giving rates stay very small. Finally, this book covers the emergence of large giving vehicles, modelled after the private equity industry. They have sophisticated third-party managers focused on deploying funds and supporting management teams. It also covers the scaling of nonprofits in a significant way ("Big Bets") as well as investing large philanthropy through for-profits as Program Related Investments (PRI) at scale. This book is of interest specifically to nonprofit and foundation leaders, as well as wealth managers, estate attorneys and other philanthropic advisors. It is also of interest to investors and corporate CEOs as they begin to access these large pools for philanthropic capital to increase their impact. This book is focused on providing those with the ability to make large philanthropic investments a path to scale their impact and increase their fulfillment and that of their family. It provides a step-by-step guide of how these approaches, especially PRI at scale, can actually solve the social and environmental challenges that have been seemingly hopeless.

This is the first book on one of Wales's greatest leaders, arguably 'first prince of Wales', Bleddyn ap Cynfyn. Bleddyn was at the heart of the tumultuous events that forged Britain in the cauldron of Norman aggression, and his reign offers an important new perspective on the events of 1066 and beyond. He was a leader who used alliances on the wider British scale as he strove to recreate the fledgling kingdom of Wales that had been built and ruled by his brother, though outside pressures and internal intrigues meant his successors would compete ultimately for a principality.

This book highlights the historic inflection point we are in, both in terms of philanthropy in general, and specifically in financing the solutions to our largest and most urgent social and environmental problems. It covers the two movements that have recently had a dramatic influence on capitalism. First, wealthy millennials have been pressuring their bankers to invest their family portfolios in companies with high social and environmental impact (ESG ratings), triggering a wave where the wealth management industry, and now all public companies, are significantly adapting to the increasing demand for good. Second, The Giving Pledge triggered another wave, changing what success and the accumulation of wealth means. It has even begun to redefine the goal of capitalism as more than 200 billionaires have pledged to give half or more of their wealth away. This book also focuses on the bottleneck problem that The Giving Pledge has created, as it is very hard to give hundreds of billions away with measurable impact to nonprofits lacking detailed long-term plans to scale. Nonprofits have never had the luxury of having all the resources to invest in the planning, management training and systems needed to rapidly expand. Thus taking in very large gifts is very difficult, and almost impossible to justify. Large philanthropy can always be used for traditional capital campaigns and to fund endowments, yet The Giving Pledge signers are often looking for large visible impact beyond these traditional avenues. The result is a bottleneck which has grown as more billionaires pledge their funds away while their wealth continues to skyrocket and giving rates stay very small. Finally, this book covers the emergence of large giving vehicles, modelled after the private equity industry. They have sophisticated third-party managers focused on deploying funds and supporting management teams. It also covers the scaling of nonprofits in a significant way ("Big Bets") as well as investing large philanthropy through for-profits as Program Related Investments (PRI) at scale. This book is of interest specifically to nonprofit and foundation leaders, as well as wealth managers, estate attorneys and other philanthropic advisors. It is also of interest to investors and corporate CEOs as they begin to access these large pools for philanthropic capital to increase their impact. This book is focused on providing those with the ability to make large philanthropic investments a path to scale their impact and increase their fulfillment and that of their family. It provides a step-by-step guide of how these approaches, especially PRI at scale, can actually solve the social and environmental challenges that have been seemingly hopeless.

Gruffudd ap Llywelyn was Wales’ greatest king. Ambitious and battle-sure, he succeeded in doing what no Welsh king before him was capable of: he ruled all Wales as a united and independent state. He went further by turning the Viking threat to his realm into a powerful weapon and conquering border land that had been in English hands for centuries. Having emerged as a war leader, Gruffudd also proved to be much more: a patron of the arts and church, with the trappings of a king who was respected and feared on the European stage. His eventual murder at the hands of his own men narrowed the country’s political ambitions and left Wales in chaos on the eve of the arrival of the Normans. Those who betrayed Gruffudd were the forebears of the famous princes who would dominate Wales until the Edwardian Conquest, meaning that the former king left no one to tell of his glory. As a result, 1,000 years after his birth, the would-be nation builder is all but forgotten. Here, Sean and Michael Davies reveal the king in all his glory, telling for the first time the story of one of Wales’ greatest figures and exploring the full implications of Gruffudd’s rule. For, without Gruffudd, the fate of King Harold and the outcome of the Battle of Hastings would have been very different…

Edward I s conquest of Wales was a key formative event in the history of Britain, but it has not been the subject of a scholarly book for over 100 years. Research has advanced since then, changing our perception of the medieval military mind and shining fresh light on the key characters involved in the conquest. That is why Sean Davies s absorbing new study is so timely and important. He takes a balanced approach, giving both the Welsh and English perspectives on the war and on the brutal, mistrustful and ruthless personal motives that drove events. His account is set in the context of Welsh warfare and society from the end of Rome to the time of Edward s opening campaign in the late thirteenth century. The narrative describes in vivid detail the military history of the conflict, the sequence of campaigns, Welsh resistance, Edward s castle building and English colonization and the cost of the struggle to the Welsh and the English and the uneasy peace that followed.