This volume expands on statistical analysis of genomic data by discussing cross-cutting groundwork material, public data repositories, common applications, and representative tools for operating on genomic data. Statistical Genomics: Methods and Protocols is divided into four sections. The first section discusses overview material and resources that can be applied across topics mentioned throughout the book. The second section covers prominent public repositories for genomic data. The third section presents several different biological applications of statistical genomics, and the fourth section highlights software tools that can be used to facilitate ad-hoc analysis and data integration. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible analysis protocols, and tips on troubleshooting and avoiding known pitfalls. Through and practical, Statistical Genomics: Methods and Protocols, explores a range of both applications and tools and is ideal for anyone interested in the statistical analysis of genomic data.

This volume expands on statistical analysis of genomic data by discussing cross-cutting groundwork material, public data repositories, common applications, and representative tools for operating on genomic data. Statistical Genomics: Methods and Protocols is divided into four sections. The first section discusses overview material and resources that can be applied across topics mentioned throughout the book. The second section covers prominent public repositories for genomic data. The third section presents several different biological applications of statistical genomics, and the fourth section highlights software tools that can be used to facilitate ad-hoc analysis and data integration. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible analysis protocols, and tips on troubleshooting and avoiding known pitfalls. Through and practical, Statistical Genomics: Methods and Protocols, explores a range of both applications and tools and is ideal for anyone interested in the statistical analysis of genomic data.

This text offers an examination of Welsh military organization, strategy, tactics and conduct in war which goes beyond the military sphere and touches on all aspects of Welsh society in this period. It helps to explain the transformation of the country from a part of post-Roman medieval Europe to the series of independent principalities eventually conquered by Edward I. The author questions many of the traditional assumptions, notably the tendency to see the Welsh (and the Irish and the Scottish) as "barbaric" and provides a corrective to these current views. It demonstrates that, whilst allowing for differences given the nature, economy, geography and topography of the country, Welsh military developments from the end of Roman rule to the Edwardian conquest generally correspond to those seen in the rest of Western Europe.

This book highlights the historic inflection point we are in, both in terms of philanthropy in general, and specifically in financing the solutions to our largest and most urgent social and environmental problems. It covers the two movements that have recently had a dramatic influence on capitalism. First, wealthy millennials have been pressuring their bankers to invest their family portfolios in companies with high social and environmental impact (ESG ratings), triggering a wave where the wealth management industry, and now all public companies, are significantly adapting to the increasing demand for good. Second, The Giving Pledge triggered another wave, changing what success and the accumulation of wealth means. It has even begun to redefine the goal of capitalism as more than 200 billionaires have pledged to give half or more of their wealth away. This book also focuses on the bottleneck problem that The Giving Pledge has created, as it is very hard to give hundreds of billions away with measurable impact to nonprofits lacking detailed long-term plans to scale. Nonprofits have never had the luxury of having all the resources to invest in the planning, management training and systems needed to rapidly expand. Thus taking in very large gifts is very difficult, and almost impossible to justify. Large philanthropy can always be used for traditional capital campaigns and to fund endowments, yet The Giving Pledge signers are often looking for large visible impact beyond these traditional avenues. The result is a bottleneck which has grown as more billionaires pledge their funds away while their wealth continues to skyrocket and giving rates stay very small. Finally, this book covers the emergence of large giving vehicles, modelled after the private equity industry. They have sophisticated third-party managers focused on deploying funds and supporting management teams. It also covers the scaling of nonprofits in a significant way ("Big Bets") as well as investing large philanthropy through for-profits as Program Related Investments (PRI) at scale. This book is of interest specifically to nonprofit and foundation leaders, as well as wealth managers, estate attorneys and other philanthropic advisors. It is also of interest to investors and corporate CEOs as they begin to access these large pools for philanthropic capital to increase their impact. This book is focused on providing those with the ability to make large philanthropic investments a path to scale their impact and increase their fulfillment and that of their family. It provides a step-by-step guide of how these approaches, especially PRI at scale, can actually solve the social and environmental challenges that have been seemingly hopeless.

This book highlights the historic inflection point we are in, both in terms of philanthropy in general, and specifically in financing the solutions to our largest and most urgent social and environmental problems. It covers the two movements that have recently had a dramatic influence on capitalism. First, wealthy millennials have been pressuring their bankers to invest their family portfolios in companies with high social and environmental impact (ESG ratings), triggering a wave where the wealth management industry, and now all public companies, are significantly adapting to the increasing demand for good. Second, The Giving Pledge triggered another wave, changing what success and the accumulation of wealth means. It has even begun to redefine the goal of capitalism as more than 200 billionaires have pledged to give half or more of their wealth away. This book also focuses on the bottleneck problem that The Giving Pledge has created, as it is very hard to give hundreds of billions away with measurable impact to nonprofits lacking detailed long-term plans to scale. Nonprofits have never had the luxury of having all the resources to invest in the planning, management training and systems needed to rapidly expand. Thus taking in very large gifts is very difficult, and almost impossible to justify. Large philanthropy can always be used for traditional capital campaigns and to fund endowments, yet The Giving Pledge signers are often looking for large visible impact beyond these traditional avenues. The result is a bottleneck which has grown as more billionaires pledge their funds away while their wealth continues to skyrocket and giving rates stay very small. Finally, this book covers the emergence of large giving vehicles, modelled after the private equity industry. They have sophisticated third-party managers focused on deploying funds and supporting management teams. It also covers the scaling of nonprofits in a significant way ("Big Bets") as well as investing large philanthropy through for-profits as Program Related Investments (PRI) at scale. This book is of interest specifically to nonprofit and foundation leaders, as well as wealth managers, estate attorneys and other philanthropic advisors. It is also of interest to investors and corporate CEOs as they begin to access these large pools for philanthropic capital to increase their impact. This book is focused on providing those with the ability to make large philanthropic investments a path to scale their impact and increase their fulfillment and that of their family. It provides a step-by-step guide of how these approaches, especially PRI at scale, can actually solve the social and environmental challenges that have been seemingly hopeless.

This is the first book on one of Wales's greatest leaders, arguably 'first prince of Wales', Bleddyn ap Cynfyn. Bleddyn was at the heart of the tumultuous events that forged Britain in the cauldron of Norman aggression, and his reign offers an important new perspective on the events of 1066 and beyond. He was a leader who used alliances on the wider British scale as he strove to recreate the fledgling kingdom of Wales that had been built and ruled by his brother, though outside pressures and internal intrigues meant his successors would compete ultimately for a principality.

Gruffudd ap Llywelyn was Wales’ greatest king. Ambitious and battle-sure, he succeeded in doing what no Welsh king before him was capable of: he ruled all Wales as a united and independent state. He went further by turning the Viking threat to his realm into a powerful weapon and conquering border land that had been in English hands for centuries. Having emerged as a war leader, Gruffudd also proved to be much more: a patron of the arts and church, with the trappings of a king who was respected and feared on the European stage. His eventual murder at the hands of his own men narrowed the country’s political ambitions and left Wales in chaos on the eve of the arrival of the Normans. Those who betrayed Gruffudd were the forebears of the famous princes who would dominate Wales until the Edwardian Conquest, meaning that the former king left no one to tell of his glory. As a result, 1,000 years after his birth, the would-be nation builder is all but forgotten. Here, Sean and Michael Davies reveal the king in all his glory, telling for the first time the story of one of Wales’ greatest figures and exploring the full implications of Gruffudd’s rule. For, without Gruffudd, the fate of King Harold and the outcome of the Battle of Hastings would have been very different…

Edward I s conquest of Wales was a key formative event in the history of Britain, but it has not been the subject of a scholarly book for over 100 years. Research has advanced since then, changing our perception of the medieval military mind and shining fresh light on the key characters involved in the conquest. That is why Sean Davies s absorbing new study is so timely and important. He takes a balanced approach, giving both the Welsh and English perspectives on the war and on the brutal, mistrustful and ruthless personal motives that drove events. His account is set in the context of Welsh warfare and society from the end of Rome to the time of Edward s opening campaign in the late thirteenth century. The narrative describes in vivid detail the military history of the conflict, the sequence of campaigns, Welsh resistance, Edward s castle building and English colonization and the cost of the struggle to the Welsh and the English and the uneasy peace that followed.

On September 12, 2001, a year and a half after finishing his military service, Sean Davis strolled into the Oregon National Guard's recruiting office and re-enlisted. After dropping out of art school and working a dead-end government job, September 11 gave him a new sense of purpose and direction. Follow Sean Davis' life as he discovers the oddities of a pop-up America in a hostile desert wasteland; loses his best friend in a violent ambush; returns, critically wounded, to confinement in a place that's not his home; deals with the fallout of PTSD and the horror of what he experienced in that war zone; and finally, as he rediscovers art and its power to heal.