This book constitutes the proceedings of the 19th Russian Conference on Artificial Intelligence, RCAI 2021, held in Moscow, Russia, in October 2021. The 19 full papers and 7 short papers presented in this volume were carefully reviewed and selected from 80 submissions. The conference deals with a wide range of topics, categorized into the following topical headings: cognitive research; data mining, machine learning, classification; knowledge engineering; multi-agent systems and robotics; natural language processing; fuzzy models and soft computer; intelligent systems; and tools for designing intelligent systems.