This volume constitutes refereed proceedings of the 6th International Conference on Digital Transformation and Global Society, DTGS 2021, held as a virtual event in June 2021. Due to the COVID-19 pandemic the conference was held online. The 34 revised full papers and 4 short papers presented in the volume were carefully reviewed and selected from 95 submissions. The papers are organized in topical sections on eSociety: social informatics and digital inclusion issues; ePolity: e-governance and regulation; eCity: smart cities and urban planning; eHumanities: digital education and research methods; eCommunication: online discources and attitudes; eEconomy: challenges of the COVID-19 pandemic; eEconomy: e-commerce research.