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Biological membranes are often effected by diseases. Molecular
events leading to or arising from pathological changes in the
course of different diseases are as yet not clearly understood.
This competent study by leading experts covers changes of the
cellular environment, membranes and the metabolic functions during
tissue growth and differentiation as well as aspects of abnormal
organelle function in lysosomal storage diseases, peroxisomal and
mitochondrial disorders, enzyme defects and regulatory defects of
receptors due to oncogenes.
Every year, the Federation of European Biochemical Societies
sponsors a series of Advanced Courses designed to acquaint
postgraduate students and young postdoctoral fellows with
theoretical and practical aspects of topics of current interest in
biochemistry, particularly within areas in which significant
advances are being made. This volume contains the Proceedings of
FEBS Advanced Course No. 88-02 held in Bari, Italy on the topic
"Organelles of Eukaryotic Cells: Molecular Structure and
Interactions. " It was a deliberate decision of the organizers not
to restrict FEBS Advanced Course 88-02 to a discussion of a single
organelle or a single aspect but to cover a broad area. One of the
objectives of the course was to compare different organelles in
order to allow the participants to discern recurrent themes which
would illustrate that a basic unity exists in spite of the
diversity. A second objective of the course was to acquaint the
participants with the latest experimental approaches being used by
in vestigators to study different organelles; this would illustrate
that methodologies developed for studying the biogenesis of the
structure-function relationships in one organelle can often be
applied fruitfully to investi gate such aspects in other
organelles. A third objective was to impress upon the participants
that a study of the interaction between different organelles is
intrinsic to understanding their physiological functions. This
volume is divided into five sections. Part I is entitled "Structure
and Organization of Intracellular Organelles."
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