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Showing 1 - 3 of 3 matches in All Departments

Natural HDAC Inhibitors for Epigenetic Combating of Cancer Progression (Hardcover): Shabir Ahmad Ganai Natural HDAC Inhibitors for Epigenetic Combating of Cancer Progression (Hardcover)
Shabir Ahmad Ganai
R2,780 Discovery Miles 27 800 Ships in 9 - 15 working days

General compendium of HDAC inhibitors with deep emphasis on toxicity issues of synthetic HDAC inhibitors Various groups of natural HDAC inhibitors, their representatives and premier sources Cyclic tetrapeptides of natural origin and their importance as cancer chemotherapeutic agents Hydroxamates and depsipeptides from natural sources and their promising role in cancer therapy Natural Flavonoids, their HDAC inhibitory tendency and marvellous anticancer activity Non-flavonoid natural HDAC inhibitors and their pleasing cytotoxic effects towards cancer models Combined therapy involving natural flavonoids with other anticancer molecules for synergistic and additive benefits against cancer models Non-flavonoid HDAC inhibitors and conventional drugs in collaborative mode against aggressive malignancies Nanotechnology based delivery of natural HDAC inhibitors for greater therapeutic efficacy over traditional combinatorial therapy

Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy (Hardcover, 1st ed. 2020): Shabir Ahmad Ganai Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy (Hardcover, 1st ed. 2020)
Shabir Ahmad Ganai
R4,584 Discovery Miles 45 840 Ships in 10 - 15 working days

This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation and apoptosis of cancer cells with tumor selective toxicity. The book begins with an overview of various epigenetic modifying enzymes that are involved in cancer transition and progression; before exploring the potential of HDACs in cancer treatment. It provides a classification of HDAC inhibitors based on their structural attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it discusses and assesses the rationale behind therapies that combine HDAC inhibitors with other anticancer agents to treat solid tumors. Given its scope, it offers a valuable resource for all researchers, clinicians, and students working in formulation, drug discovery, oncology, and personalized medicine.

Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy (Paperback, 1st ed. 2020): Shabir Ahmad Ganai Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy (Paperback, 1st ed. 2020)
Shabir Ahmad Ganai
R4,551 Discovery Miles 45 510 Ships in 10 - 15 working days

This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation and apoptosis of cancer cells with tumor selective toxicity. The book begins with an overview of various epigenetic modifying enzymes that are involved in cancer transition and progression; before exploring the potential of HDACs in cancer treatment. It provides a classification of HDAC inhibitors based on their structural attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it discusses and assesses the rationale behind therapies that combine HDAC inhibitors with other anticancer agents to treat solid tumors. Given its scope, it offers a valuable resource for all researchers, clinicians, and students working in formulation, drug discovery, oncology, and personalized medicine.

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