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General compendium of HDAC inhibitors with deep emphasis on
toxicity issues of synthetic HDAC inhibitors Various groups of
natural HDAC inhibitors, their representatives and premier sources
Cyclic tetrapeptides of natural origin and their importance as
cancer chemotherapeutic agents Hydroxamates and depsipeptides from
natural sources and their promising role in cancer therapy Natural
Flavonoids, their HDAC inhibitory tendency and marvellous
anticancer activity Non-flavonoid natural HDAC inhibitors and their
pleasing cytotoxic effects towards cancer models Combined therapy
involving natural flavonoids with other anticancer molecules for
synergistic and additive benefits against cancer models
Non-flavonoid HDAC inhibitors and conventional drugs in
collaborative mode against aggressive malignancies Nanotechnology
based delivery of natural HDAC inhibitors for greater therapeutic
efficacy over traditional combinatorial therapy
This book reviews the latest developments in the design, synthesis,
and molecular mechanism of action of Histone Deacetylase (HDAC)
inhibitors in the context of potential cancer therapy. HDAC
inhibitors are emerging as promising anticancer drug molecules that
promote growth arrest, differentiation and apoptosis of cancer
cells with tumor selective toxicity. The book begins with an
overview of various epigenetic modifying enzymes that are involved
in cancer transition and progression; before exploring the
potential of HDACs in cancer treatment. It provides a
classification of HDAC inhibitors based on their structural
attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it
discusses and assesses the rationale behind therapies that combine
HDAC inhibitors with other anticancer agents to treat solid tumors.
Given its scope, it offers a valuable resource for all researchers,
clinicians, and students working in formulation, drug discovery,
oncology, and personalized medicine.
This book reviews the latest developments in the design, synthesis,
and molecular mechanism of action of Histone Deacetylase (HDAC)
inhibitors in the context of potential cancer therapy. HDAC
inhibitors are emerging as promising anticancer drug molecules that
promote growth arrest, differentiation and apoptosis of cancer
cells with tumor selective toxicity. The book begins with an
overview of various epigenetic modifying enzymes that are involved
in cancer transition and progression; before exploring the
potential of HDACs in cancer treatment. It provides a
classification of HDAC inhibitors based on their structural
attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it
discusses and assesses the rationale behind therapies that combine
HDAC inhibitors with other anticancer agents to treat solid tumors.
Given its scope, it offers a valuable resource for all researchers,
clinicians, and students working in formulation, drug discovery,
oncology, and personalized medicine.
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