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Medicinal chemistry is both science and art. The science of
medicinal chemistry offers mankind one of its best hopes for
improving the quality of life. The art of medicinal chemistry
continues to challenge its practitioners with the need for both
intuition and experience to discover new drugs. Hence sharing the
experience of drug research is uniquely beneficial to the field of
medicinal chemistry. Drug research requires interdisciplinary
team-work at the interface between chemistry, biology and medicine.
Therefore, the topic-related series Topics in Medicinal Chemistry
covers all relevant aspects of drug research, e.g.
pathobiochemistry of diseases, identification and validation of
(emerging) drug targets, structural biology, drugability of
targets, drug design approaches, chemogenomics, synthetic chemistry
including combinatorial methods, bioorganic chemistry, natural
compounds, high-throughput screening, pharmacological in vitro and
in vivo investigations, drug-receptor interactions on the molecular
level, structure-activity relationships, drug absorption,
distribution, metabolism, elimination, toxicology and
pharmacogenomics. In general, special volumes are edited by well
known guest editors
Medicinal chemistry is both science and art. The science of
medicinal chemistry offers mankind one of its best hopes for
improving the quality of life. The art of medicinal chemistry
continues to challenge its practitioners with the need for both
intuition and experience to discover new drugs. Hence sharing the
experience of drug research is uniquely beneficial to the field of
medicinal chemistry. Drug research requires interdisciplinary
team-work at the interface between chemistry, biology and medicine.
Therefore, the topic-related series Topics in Medicinal Chemistry
covers all relevant aspects of drug research, e.g.
pathobiochemistry of diseases, identification and validation of
(emerging) drug targets, structural biology, drugability of
targets, drug design approaches, chemogenomics, synthetic chemistry
including combinatorial methods, bioorganic chemistry, natural
compounds, high-throughput screening, pharmacological in vitro and
in vivo investigations, drug-receptor interactions on the molecular
level, structure-activity relationships, drug absorption,
distribution, metabolism, elimination, toxicology and
pharmacogenomics. In general, special volumes are edited by well
known guest editors
The title of this proceedings comes from the book The Antibiotic
Paradox by Stuart B. Levy (Plenum Publishing Corporation, 1992),
referring to the paradox that the more antibiotics are used to
treat infectious diseases, the less effective they become. When
antibiotics were first introduced, they were considered wonder
drugs because they were so effective. But with time bacteria have
become resistant to nearly all antibiotics, and resistance is
spreading faster than new antibiotics are being developed. This
book will identify the issues concerning resistance, as well as
describe efforts to develop new drugs that overcome the problem of
resistance.
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