The Statistical Analysis of Multivariate Failure Time Data: A Marginal Modeling Approach provides an innovative look at methods for the analysis of correlated failure times. The focus is on the use of marginal single and marginal double failure hazard rate estimators for the extraction of regression information. For example, in a context of randomized trial or cohort studies, the results go beyond that obtained by analyzing each failure time outcome in a univariate fashion. The book is addressed to researchers, practitioners, and graduate students, and can be used as a reference or as a graduate course text. Much of the literature on the analysis of censored correlated failure time data uses frailty or copula models to allow for residual dependencies among failure times, given covariates. In contrast, this book provides a detailed account of recently developed methods for the simultaneous estimation of marginal single and dual outcome hazard rate regression parameters, with emphasis on multiplicative (Cox) models. Illustrations are provided of the utility of these methods using Women's Health Initiative randomized controlled trial data of menopausal hormones and of a low-fat dietary pattern intervention. As byproducts, these methods provide flexible semiparametric estimators of pairwise bivariate survivor functions at specified covariate histories, as well as semiparametric estimators of cross ratio and concordance functions given covariates. The presentation also describes how these innovative methods may extend to handle issues of dependent censorship, missing and mismeasured covariates, and joint modeling of failure times and covariates, setting the stage for additional theoretical and applied developments. This book extends and continues the style of the classic Statistical Analysis of Failure Time Data by Kalbfleisch and Prentice. Ross L. Prentice is Professor of Biostatistics at the Fred Hutchinson Cancer Research Center and University of Washington in Seattle, Washington. He is the recipient of COPSS Presidents and Fisher awards, the AACR Epidemiology/Prevention and Team Science awards, and is a member of the National Academy of Medicine. Shanshan Zhao is a Principal Investigator at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina.

This book focuses on the calculus of variations, including fundamental theories and applications. This textbook is intended for graduate and higher-level college and university students, introducing them to the basic concepts and calculation methods used in the calculus of variations. It covers the preliminaries, variational problems with fixed boundaries, sufficient conditions of extrema of functionals, problems with undetermined boundaries, variational problems of conditional extrema, variational problems in parametric forms, variational principles, direct methods for variational problems, variational principles in mechanics and their applications, and variational problems of functionals with vector, tensor and Hamiltonian operators. Many of the contributions are based on the authors' research, addressing topics such as the extension of the connotation of the Hilbert adjoint operator, definitions of the other three kinds of adjoint operators, the extremum function theorem of the complete functional, unified Euler equations in variational methods, variational theories of functionals with vectors, modulus of vectors, arbitrary order tensors, Hamiltonian operators and Hamiltonian operator strings, reconciling the Euler equations and the natural boundary conditions, and the application range of variational methods. The book is also a valuable reference resource for teachers as well as science and technology professionals.

This book focuses on the calculus of variations, including fundamental theories and applications. This textbook is intended for graduate and higher-level college and university students, introducing them to the basic concepts and calculation methods used in the calculus of variations. It covers the preliminaries, variational problems with fixed boundaries, sufficient conditions of extrema of functionals, problems with undetermined boundaries, variational problems of conditional extrema, variational problems in parametric forms, variational principles, direct methods for variational problems, variational principles in mechanics and their applications, and variational problems of functionals with vector, tensor and Hamiltonian operators. Many of the contributions are based on the authors' research, addressing topics such as the extension of the connotation of the Hilbert adjoint operator, definitions of the other three kinds of adjoint operators, the extremum function theorem of the complete functional, unified Euler equations in variational methods, variational theories of functionals with vectors, modulus of vectors, arbitrary order tensors, Hamiltonian operators and Hamiltonian operator strings, reconciling the Euler equations and the natural boundary conditions, and the application range of variational methods. The book is also a valuable reference resource for teachers as well as science and technology professionals.

The Statistical Analysis of Multivariate Failure Time Data: A Marginal Modeling Approach provides an innovative look at methods for the analysis of correlated failure times. The focus is on the use of marginal single and marginal double failure hazard rate estimators for the extraction of regression information. For example, in a context of randomized trial or cohort studies, the results go beyond that obtained by analyzing each failure time outcome in a univariate fashion. The book is addressed to researchers, practitioners, and graduate students, and can be used as a reference or as a graduate course text. Much of the literature on the analysis of censored correlated failure time data uses frailty or copula models to allow for residual dependencies among failure times, given covariates. In contrast, this book provides a detailed account of recently developed methods for the simultaneous estimation of marginal single and dual outcome hazard rate regression parameters, with emphasis on multiplicative (Cox) models. Illustrations are provided of the utility of these methods using Women's Health Initiative randomized controlled trial data of menopausal hormones and of a low-fat dietary pattern intervention. As byproducts, these methods provide flexible semiparametric estimators of pairwise bivariate survivor functions at specified covariate histories, as well as semiparametric estimators of cross ratio and concordance functions given covariates. The presentation also describes how these innovative methods may extend to handle issues of dependent censorship, missing and mismeasured covariates, and joint modeling of failure times and covariates, setting the stage for additional theoretical and applied developments. This book extends and continues the style of the classic Statistical Analysis of Failure Time Data by Kalbfleisch and Prentice. Ross L. Prentice is Professor of Biostatistics at the Fred Hutchinson Cancer Research Center and University of Washington in Seattle, Washington. He is the recipient of COPSS Presidents and Fisher awards, the AACR Epidemiology/Prevention and Team Science awards, and is a member of the National Academy of Medicine. Shanshan Zhao is a Principal Investigator at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina.