The collection of essays in Microbes in Agriculture and Environmental Development explores the applications of microbes for the improvement of environmental quality and agricultural productivity through inoculants and enzymes. These are useful for the conservation and restoration of degraded natural and agricultural ecosystems, crop yield extension, soil health improvement, and other aspects of agriculture and the environment. It discusses the effective use of microbial technology, wastewater treatment, and recycling of agricultural and industrial wastes. It provides detailed accounts of recent trends in microbial application in plant growth promotion, soil fertility, microbial biomass and diversity, and environmental sustainability through bioremediation, biodegradation, and biosorption processes Features: Discusses microbes and their applications for sustainable agriculture and environmental protection in agro-environmental circumstances Presents innovative and eco-friendly approaches for the remediation of contaminated soil and wastewater Focuses on green technologies and sustainability Includes chapters on sustainable agriculture development through increasing soil fertility, physico-chemical properties and soil microbial biomass in nutrient-deprived soils Defines the role of microbial bio formulation-based consortia in the productivity improvement of agricultural crops It will be an invaluable addition to the bookshelves of researchers and graduate students in agriculture and environmental engineering, soil science; microbiology, sustainable agriculture, and ecosystems. Dr. Chhatarpal Singh is presently the President of Agro Environmental Development Society (AEDS), Majhra Ghat, Rampur, Uttar Pradesh, India. Dr. Tiwari is currently working in the field of methanotrophs ecology (methane oxidizing bacteria), which is sole entity responsible for the oxidation of potent greenhouse gas CH4. Dr. Jay Shankar Singh is presently working as a faculty member in the Department of Environmental Microbiology at Babasaheb Bhimrao Ambedkar University in Lucknow, India. Dr. Ajar Nath Yadav is currently serving as an assistant professor in the Department of Biotechnology, Akal College of Agriculture, Eternal University, Baru Sahib, Himachal Pradesh, India.

The collection of essays in Microbes in Agriculture and Environmental Development explores the applications of microbes for the improvement of environmental quality and agricultural productivity through inoculants and enzymes. These are useful for the conservation and restoration of degraded natural and agricultural ecosystems, crop yield extension, soil health improvement, and other aspects of agriculture and the environment. It discusses the effective use of microbial technology, wastewater treatment, and recycling of agricultural and industrial wastes. It provides detailed accounts of recent trends in microbial application in plant growth promotion, soil fertility, microbial biomass and diversity, and environmental sustainability through bioremediation, biodegradation, and biosorption processes Features: Discusses microbes and their applications for sustainable agriculture and environmental protection in agro-environmental circumstances Presents innovative and eco-friendly approaches for the remediation of contaminated soil and wastewater Focuses on green technologies and sustainability Includes chapters on sustainable agriculture development through increasing soil fertility, physico-chemical properties and soil microbial biomass in nutrient-deprived soils Defines the role of microbial bio formulation-based consortia in the productivity improvement of agricultural crops It will be an invaluable addition to the bookshelves of researchers and graduate students in agriculture and environmental engineering, soil science; microbiology, sustainable agriculture, and ecosystems. Dr. Chhatarpal Singh is presently the President of Agro Environmental Development Society (AEDS), Majhra Ghat, Rampur, Uttar Pradesh, India. Dr. Tiwari is currently working in the field of methanotrophs ecology (methane oxidizing bacteria), which is sole entity responsible for the oxidation of potent greenhouse gas CH4. Dr. Jay Shankar Singh is presently working as a faculty member in the Department of Environmental Microbiology at Babasaheb Bhimrao Ambedkar University in Lucknow, India. Dr. Ajar Nath Yadav is currently serving as an assistant professor in the Department of Biotechnology, Akal College of Agriculture, Eternal University, Baru Sahib, Himachal Pradesh, India.

Microbes in Land Use Change Management details the various roles of microbial resources in management of land uses and how the microbes can be used for the source of income due to their cultivation for the purpose of biomass and bioenergy production. Using various techniques, the disturbed and marginal lands may also be restored eco-friendly in present era to fulfil the feeding needs of mankind around the globe. Microbes in Land Use Change Management provides standard and up to date information towards the land use change management using various microbial technologies to enhance the productivity of agriculture. Needless to say that Microbes in Land Use Change Management also considers the areas including generation of alternative energy sources, restoration of degraded and marginal lands, mitigation of global warming gases and next generation -omics technique etc. Land use change affects environment conditions and soil microbial community. Microbial population and its species diversity have influence in maintaining ecosystem balance. The study of changes of microbial population provides an idea about the variation occurring in a specific area and possibilities of restoration. Meant for a multidisciplinary audience Microbes in Land Use Change Management shows the need of next-generation omics technologies to explore microbial diversity.

AdvancED Flex 4 makes advanced Flex 4 concepts and techniques easy. Ajax, RIA, Web 2.0, mashups, mobile applications, the most sophisticated web tools, and the coolest interactive web applications are all covered with practical, visually oriented recipes.Completely updated for toolsnew toFlex 4 Demonstrates how to use Flex 4 to create robust and scalable enterprise-grade rich Internet applications Teaches you to build high-performance web applications with interactivity that really engages your users What you'll learn

Practiced beginners and intermediate users of Flex, especially those with a knowledge of other web development tools, will learn to leverage Flex 4's new tools and capabilities to build truly advanced web applications.Get the most out of the new features introduced in Flex 4 Integrate Flex 4 with PHP, Java, JavaScript, and Ruby on Rails Leverage architectural and design patterns Create mashups and collaborative applications using Flex 4 Build rich media applications using audio and video streaming and open-source 3D libraries Tune the performance of your Flex applications Who this book is for

This book is for web developers who want and need to create rich Internet applications on time and within budget. It is also for all Flex developers including those upgrading from Flex 3, intermediate users who want to build their skills to an advanced level, and other web developers who want to integrate their web tools with Flex. Table of Contents Building Applications Using Test-Driven Development Turbo-Charging Data Binding Workflow enhancements with Flash Catalyst Flex and AIR: Taking Applications to the Desktop 20 Enhancements Overview Creating Themes in Flex 4 Integrating Flex with Java Using Services Integrating via Data Services Talking with JavaScript and HTML: Web Page Integration Flex Mashups Flash Security Migrating Web 10 Interfaces to RIA Working with Web 20 APIs Facilitating Audio and Video Using 3D in Flex

Whether you're a Flex 3 beginner or intermediate user, this book provides the necessary information to help you develop into an expert. Using a practical hands-on approach, it illustrates exactly how to create robust and scalable enterprise-grade rich Internet applications (RIAs).

The book is divided into three parts. The first part discusses the architectural and design aspects of Flex 3 application development. It explains the internals of a Flex 3 application and advocates a few best practices to fine-tune your application to ensure maximum performance. It includes tutorials on creating custom components, data binding, and creating AIR-powered desktop applications.

The second part concentrates on effectively integrating Flex 3 with server- and client-side technologies. Techniques for integration with Java and PHP are covered in detail, and content covering interaction with client-side technologies is also included. After reading the chapter on JavaScript integration, you will be ready to create applications that can use Ajax and Flex 3 together.

The third and final part of the book is a unique and eclectic mix of some advanced topics like mash-ups, collaborative applications, 3D rendering, highly interactive visualization, and audio and video streaming.

In summary, through reading this book, you will benefit from the wealth of information and years of experience the authors hold, and will then be ready to cruise with comfort in the world of Flex 3 application development on your own.

Validation is defined as the establishing of documented evidence which provides a high degree of assurance that a planned process will consistently perform according to the intended specified outcomes. Validation studies are performed for analytical tests, equipment, facility systems such as air, water, steam, and for processes such as the manufacturing processes, cleaning, sterilization, sterile filling, lyophilization, etc. There will be a separate validation for the lyophilizer as an equipment item and for the lyophilization process; for the cleaning of glassware and the cleaning of the facility; and for the sterilization process and for the sterility test. Every step of the process of manufacture of a drug product must be shown to perform as intended. Validation studies verify the system under test under the extremes expected during the process to prove that the system remains in control. Once the system or process has been validated, it is expected that it remains in control, provided no changes are made. In the event that modifications are made, or problems occur, or equipment is replaced or relocated, revalidation is performed.

Scale up is generally defined as the process of increasing batch size. In process scale up a formula is transformed into a viable, robust product by the development of a reliable and practical method of manufacturing that effect the orderly transition from laboratory to routine processing in a full-scale production facility. It must include a close examination of the formula to determine its ability to withstand batch-scale and process modification. So process scale up of Metformin HCL tablet includes Trial Batches, Exhibit Batches and Validation Batch. After these batches produce large scale up Metformin HCL Tablets. During the scale up process controls are evaluated, valuated and finalized in addition, appropriate records and report are issued to support good manufacturing practices and to provide the historical development of the production, formulation, process equipments train, and specification.