Most doctors believe gastrointestinal stromal tumors (GISTs) start in special cells found in the wall of the GI tract, called the interstitial cells of Cajal (ICCs), or in very early cells that can develop into ICCs. ICCs are part of the autonomic nervous system, which sends signals to the GI tract. Some have called these cells the "pacemakers" of the GI tract because the nerve signals they send cause muscles of the digestive organs to contract, which helps to move food and liquid through the GI tract. This issue is an important one because GISTs are rare and are quite different in their outlook for survival and their treatment than other gastrointestinal tumors. For these reasons, oncologists need to figure out whether a patient has a GIST, an adenoma, an adenocarcinoma, a neuroendocrine cancer, some other type of tumor, or a non-cancerous condition. By presenting state-of-the-art information on the diagnosis, treatment, and management of GISTs, this issue serves as an important guide to oncologists as they work with patients to make make informed decisions about treatment options.

"Bone Sarcoma "is a succinct volume within the M.D. Anderson Cancer Care Series that summarizes the key elements of different specialties as they pertain to these cancers. It is a vital resource for physicians working with these uncommon yet fascinating bone sarcomas and uses a multidisciplinary team approach that is essential to maximizing a patient s chances of a successful outcome. Written for physicians who have an interest in how the entire treatment process works and how their efforts are intertwined with those of their colleagues, "Bone Sarcoma "covers topics such as diagnostic techniques, treatment modalities, reconstruction and function, and a more globally oriented chapter geared towards algorithms for perioperative management and follow-up of patients.
Designed for the busy practitioner, the esteemed M.D. Anderson Cancer Care Series offers an in-depth view of the current standard of care at M. D. Anderson, without extensive literature review or discussion of approaches not yet incorporated into routine clinical practice. Each chapter ends with an up-to-date list of suggested readings and a list of key practice points highlighting the most important principles presented. These books offer a clear picture of how M. D. Anderson is successfully treating patients today.