In the past 30 years, gastroesophageal and reflux disease (GERD) has become an important area of clinical medicine. GERD has gradually become associated with other common but unexplained disorders. These conditions have been designated as the extraesophageal manifestations of GERD. Dr. Anthony J. DiMarino, Jr. and Dr. Sidney Cohen and their contributors have written Extraesophageal Manifestations of GERD with the purpose to identify associations with conditions like hoarseness, laryngeal cancer, sleep disorders, and dental caries, and to explore possible causation and mechanisms of disease or possible noncausal relationships. The extraesophageal disorders have become widely accepted in clinical practice. The evidence supporting the pathogenesis of these conditions falls into three major categories: guilt by association, observed mechanistic studies, and therapeutic response to treatment. Inside the pages of Extraesophageal Manifestations of GERD the reader will find recognition and balance in treating patients with common symptom-based disorders. Final resolution of some of the controversies inherent in these associations may require advanced diagnostic tools and advanced pharmacological therapies. With chapters written by experts in the fields of medicine, pediatrics, otolaryngology, and dentistry, Extraesophageal Manifestations of GERD will be a must have for gastroenterologists, internal medicine residents, surgeons, otolaryngologists, and pediatricians.

Scientific information about cannabis and its components has grown exponentially during the past decade. Certain of the findings have led to exploratory studies into the therapeutic utility of the drug. At the present time, a number of areas of usefulness have been investigated, with some showing greater promise than others. At what point should these data be collected and presented? Should it be early, after some initial impressions have been obtained? Or should it come later, following confirmatory studies by others? Both stages of development are represented in this volume. In a number of instances, the papers consist of hitherto unpublished material. It seemed worthwhile to bring together the investigators working in a wide variety of disciplines who had in common their research activities in the therapeutic aspects of the cannabinoids and related synthetic compounds. This was done at the Asilomar Conference Center in Pacific Grove, California during November, 1975. The papers presented and the ensuing discussion constitute the contents of this volume. It is the Editors' hope that the book will stimulate further involvement in the therapeutic studies. It should not be expected, nor is it anticipated that some cannabinoid will be available commercially in the near future. The nature of the approval process is such that years elapse between initial testing, however promising, and final approval for marketing. This is particularly true for a completely new chemical entity, and even more so for one with a checkered reputation.

Out of print for more than half a century, LSD: A Journey into the Asked, the Answered, and the Unknown, is now available in a commemorative edition, with candid commentary, a new introduction by counterculture journalist Jessica Hundley, and a photographic portrait of a generation. In the midst of a raging national controversy around the indiscriminate use of LSD, two authorities – Richard Alpert, PhD (AKA Ram Dass) and psychoanalyst Sidney Cohen, MD – spoke out on the dangers, merits, legal regulations and control of the revolutionary psychedelic drug. Their book was illustrated with a groundbreaking photo essay by journalist Lawrence Schiller, whose cover story for Life magazine introduced America to the sweeping new LSD epidemic and was a precursor to the federal criminalization of the drug. As the first national photojournalist to capture the American acid scene from the inside, Schiller began with a single contact in Berkeley, California, and built a large network of young, receptive subjects who allowed him to document their private experiences with LSD. At first, his contacts were few and difficult. “Many of them were afraid,� and said no. There were others, however, who were trying to exercise their rebellion, “and some…had a sort of missionary quality. They not only wanted to tell about their experiences; they seemed as though they had to.� Schiller’s reporting expanded to include Timothy Leary, then on trial in Laredo, Texas, and the Merry Pranksters, who stopped by his studio for stroboscopic photos after the Hollywood Acid Test. The deeper he went into the story, the more questions he had. Questions like, “Is the LSD state reality or illusion?� and “Can you understand…without having had “the experience?� Figuring others did as well, he asked Alpert and Cohen to answer them for readers—from their two opposing points of view. The unexpected result is perhaps one of the most deeply informative documents on psychedelics ever published. It sold close to a million copies. At a time when the use of consciousness-expanding substances is again making headlines, the moment that LSD burst out from the rarified world of Timothy Leary and Richard Alpert’s experiments at Harvard to acid parties on the Sunset Strip is worth a second look.