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In the past 30 years, gastroesophageal and reflux disease (GERD)
has become an important area of clinical medicine. GERD has
gradually become associated with other common but unexplained
disorders. These conditions have been designated as the
extraesophageal manifestations of GERD. Dr. Anthony J. DiMarino,
Jr. and Dr. Sidney Cohen and their contributors have written
Extraesophageal Manifestations of GERD with the purpose to identify
associations with conditions like hoarseness, laryngeal cancer,
sleep disorders, and dental caries, and to explore possible
causation and mechanisms of disease or possible noncausal
relationships. The extraesophageal disorders have become widely
accepted in clinical practice. The evidence supporting the
pathogenesis of these conditions falls into three major categories:
guilt by association, observed mechanistic studies, and therapeutic
response to treatment. Inside the pages of Extraesophageal
Manifestations of GERD the reader will find recognition and balance
in treating patients with common symptom-based disorders. Final
resolution of some of the controversies inherent in these
associations may require advanced diagnostic tools and advanced
pharmacological therapies. With chapters written by experts in the
fields of medicine, pediatrics, otolaryngology, and dentistry,
Extraesophageal Manifestations of GERD will be a must have for
gastroenterologists, internal medicine residents, surgeons,
otolaryngologists, and pediatricians.
Scientific information about cannabis and its components has grown
exponentially during the past decade. Certain of the findings have
led to exploratory studies into the therapeutic utility of the
drug. At the present time, a number of areas of usefulness have
been investigated, with some showing greater promise than others.
At what point should these data be collected and presented? Should
it be early, after some initial impressions have been obtained? Or
should it come later, following confirmatory studies by others?
Both stages of development are represented in this volume. In a
number of instances, the papers consist of hitherto unpublished
material. It seemed worthwhile to bring together the investigators
working in a wide variety of disciplines who had in common their
research activities in the therapeutic aspects of the cannabinoids
and related synthetic compounds. This was done at the Asilomar
Conference Center in Pacific Grove, California during November,
1975. The papers presented and the ensuing discussion constitute
the contents of this volume. It is the Editors' hope that the book
will stimulate further involvement in the therapeutic studies. It
should not be expected, nor is it anticipated that some cannabinoid
will be available commercially in the near future. The nature of
the approval process is such that years elapse between initial
testing, however promising, and final approval for marketing. This
is particularly true for a completely new chemical entity, and even
more so for one with a checkered reputation.
Out of print for more than half a century, LSD: A Journey into the
Asked, the Answered, and the Unknown, is now available in a
commemorative edition, with candid commentary, a new introduction
by counterculture journalist Jessica Hundley, and a photographic
portrait of a generation. In the midst of a raging national
controversy around the indiscriminate use of LSD, two authorities
– Richard Alpert, PhD (AKA Ram Dass) and psychoanalyst Sidney
Cohen, MD – spoke out on the dangers, merits, legal regulations
and control of the revolutionary psychedelic drug. Their book was
illustrated with a groundbreaking photo essay by journalist
Lawrence Schiller, whose cover story for Life magazine introduced
America to the sweeping new LSD epidemic and was a precursor to the
federal criminalization of the drug. As the first national
photojournalist to capture the American acid scene from the inside,
Schiller began with a single contact in Berkeley, California, and
built a large network of young, receptive subjects who allowed him
to document their private experiences with LSD. At first, his
contacts were few and difficult. “Many of them were afraid,”
and said no. There were others, however, who were trying to
exercise their rebellion, “and some…had a sort of missionary
quality. They not only wanted to tell about their experiences; they
seemed as though they had to.” Schiller’s reporting expanded to
include Timothy Leary, then on trial in Laredo, Texas, and the
Merry Pranksters, who stopped by his studio for stroboscopic photos
after the Hollywood Acid Test. The deeper he went into the story,
the more questions he had. Questions like, “Is the LSD state
reality or illusion?” and “Can you understand…without having
had “the experience?” Figuring others did as well, he asked
Alpert and Cohen to answer them for readers—from their two
opposing points of view. The unexpected result is perhaps one of
the most deeply informative documents on psychedelics ever
published. It sold close to a million copies. At a time when the
use of consciousness-expanding substances is again making
headlines, the moment that LSD burst out from the rarified world of
Timothy Leary and Richard Alpert’s experiments at Harvard to acid
parties on the Sunset Strip is worth a second look.
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