Raphael arrived in Rome in 1508 and remained there until his death in 1520, working as painter and architect for popes Julius II and Leo X and for the most prestigious patrons. Here the artist changed his painting style several times, looking at the works of Michelangelo, Sebastiano del Piombo and the vast repertoire of ancient painting and sculpture. In the Eternal City Raphael practised architecture for the first time, designing buildings that reflected the models of Antiquity such as the Pantheon, the descriptions deriving from written sources such as Vitruvius' treaty on architecture, and the examples of modern architects like Donato Bramante. This guide supplies essential and up to date information on all the civil or religious buildings designed or built by Raphael in Rome, and the frescoes and paintings, housed in churches or museums, whether executed in the city or arrived there at a later stage.

In 1542 Pope Paolo III Farnese, with the approval of Michelangelo, commissioned to Perino del Vaga (1501-1547) a tapestry basement for the Last Judgement in the Sistine Chapel (Vatican). The Spalliera was never completed, but its model, painted on canvas, was later acquired by cardinal Bernardino Spada to be placed in his roman palace (now Galleria Spada), where it was used in radically different fashion as a frieze, completed with parts by other artists. The book is the first in-depth study of this work and of its significance in Perino's artistic career, marked by an intense dialogue with Michelangelo's art. It also explores the importance attributed by Michelangelo to decoration, apparently antithetical to the heroic dimension for which he is celebrated The reception of the Spalliera by different artists is studied through a group of drawings deriving from it and lasting until the baroque age, as attested by Rubens.