Alongside the recent cultural turn in the humanities, there has been a noticeable return to ethical considerations. With regard to literature as well as other media, this has rekindled awareness of a tension, antagonism, or even disparity between ethics and aesthetics. This volume of articles takes a more systematic and cross-disciplinary approach to the widely mooted ethical turn in literature and other media than has been pursued so far. It brings together a wide range of critical perspectives from literary studies, media and cultural memory studies, and philosophy, tracing the complex and sometimes conflicting relationship between ethics and aesthetics in theoretical contexts and individual case studies as diverse as colonial architecture, nineteenth-century literary histories, and postmodern writing and art.

Thomas Pynchon's fiction has been considered masculinist, misogynist, phallocentric, and pornographic: its formal experimentation, irony, and ambiguity have been taken both to complicate such judgments and to be parts of the problem. To the present day, deep critical divisions persist as to whether Pynchon's representations of women are sexist, feminist, or reflective of a more general misanthropy, whether his writing of sex is boorishly pornographic or effectually transgressive, whether queer identities are celebrated or mocked, and whether his departures from realist convention express masculinist elitism or critique the gendering of genre. Thomas Pynchon, Sex, and Gender reframes these debates. As the first book-length investigation of Pynchon's writing to put the topics of sex and gender at its core, it moves beyond binary debates about whether to see Pynchon as liberatory or conservative, instead examining how his preoccupation with sex and gender conditions his fiction's whole worldview. The essays it contains, which cumulatively address all of Pynchon's novels from V. (1963) to Bleeding Edge (2013), investigate such topics as the imbrication of gender and power, sexual abuse and the writing of sex, the gendering of violence, and the shifting representation of the family. Providing a wealth of new approaches to the centrality of sex and gender in Pynchon's work, the collection opens up new avenues for Pynchon studies as a whole.

Though well-known as the author of Trilby and the creator of Svengali, the writer-artist George Du Maurier had many other accomplishments that are less familiar to modern audiences. This collection traces Du Maurier's role as a participant in the wider cultural life of his time, restoring him to his proper status as a major Victorian figure. Divided into sections, the volume considers Du Maurier as an artist, illustrator and novelist who helped to form some of the key ideas of his time. The contributors place his life and work in the context of his treatment of Judaism and Jewishness; his fascination with urbanization, Victorian science, technology and clairvoyance; his friendships and influences; and his impact on notions of consumerism and taste. As an illustrator, Du Maurier collaborated with Thomas Hardy, Elizabeth Gaskell and sensational writers such as M. E. Braddon and the author of The Notting Hill Mystery. These partnerships, along with his reflections on the art of illustration, are considered in detail. Impossible to categorize, Du Maurier was an Anglo-Frenchman with cultural linkages in France, England, and America; a social commentator with an interest in The New Woman; a Punch humourist; and a friend of Henry James, with whom he shared a particular interest in the writing of domesticity and domestic settings. Closing with a consideration of Du Maurier's after-life, notably the treatment of his work in film, this collection highlights his diverse achievements and makes a case for his enduring significance.

In a reevaluation of that period in Victorian illustration known as 'The Sixties,' a distinguished group of international scholars consider the impact of illustration on the act of reading; its capacity to reflect, construct, critique and challenge its audience's values; its response to older graphic traditions; and its assimilation of foreign influences. While focused on the years 1855 to 1875, the essays take up issues related to the earlier part of the nineteenth century and look forward to subsequent developments in illustration. The contributors examine significant figures such as Ford Madox Brown, Frederick Sandys, John Everett Millais, George John Pinwell, and Hablot Knight Browne in connection with the illustrated magazine, the mid-Victorian gift book, and changing visual responses to the novels of Dickens. Engaging with a number of theories and critical debates, the collection offers a detailed and provocative analysis of the nature of illustration: its production, consumption, and place within the broader contexts of mid-Victorian culture.

Though well-known as the author of Trilby and the creator of Svengali, the writer-artist George Du Maurier had many other accomplishments that are less familiar to modern audiences. This collection traces Du Maurier's role as a participant in the wider cultural life of his time, restoring him to his proper status as a major Victorian figure. Divided into sections, the volume considers Du Maurier as an artist, illustrator and novelist who helped to form some of the key ideas of his time. The contributors place his life and work in the context of his treatment of Judaism and Jewishness; his fascination with urbanization, Victorian science, technology and clairvoyance; his friendships and influences; and his impact on notions of consumerism and taste. As an illustrator, Du Maurier collaborated with Thomas Hardy, Elizabeth Gaskell and sensational writers such as M. E. Braddon and the author of The Notting Hill Mystery. These partnerships, along with his reflections on the art of illustration, are considered in detail. Impossible to categorize, Du Maurier was an Anglo-Frenchman with cultural linkages in France, England, and America; a social commentator with an interest in The New Woman; a Punch humourist; and a friend of Henry James, with whom he shared a particular interest in the writing of domesticity and domestic settings. Closing with a consideration of Du Maurier's after-life, notably the treatment of his work in film, this collection highlights his diverse achievements and makes a case for his enduring significance.

The four sections of the book deal in succession with Marshall's key ideas on the subject, the wider context of his thought in which they are to be read, their later development by some of his pupils, and their revival in contemporary economics. The first and last sections work together to illustrate the evolutionary focus of Marshall's research program and to identify its affinity with modern industrial economics; the second explicates the social assumptions within which the Marshallian paradigm was embedded, in particular those relating to the various relationships that exist between individuals and wider groups; while the third traces the development of Marshall's views by some of his pupils.

In a reevaluation of that period in Victorian illustration known as 'The Sixties,' a distinguished group of international scholars consider the impact of illustration on the act of reading; its capacity to reflect, construct, critique and challenge its audience's values; its response to older graphic traditions; and its assimilation of foreign influences. While focused on the years 1855 to 1875, the essays take up issues related to the earlier part of the nineteenth century and look forward to subsequent developments in illustration. The contributors examine significant figures such as Ford Madox Brown, Frederick Sandys, John Everett Millais, George John Pinwell, and Hablot Knight Browne in connection with the illustrated magazine, the mid-Victorian gift book, and changing visual responses to the novels of Dickens. Engaging with a number of theories and critical debates, the collection offers a detailed and provocative analysis of the nature of illustration: its production, consumption, and place within the broader contexts of mid-Victorian culture.

The four sections of the book deal in succession with Marshall 's key ideas on the subject, the wider context of his thought in which they are to be read, their later development by some of his pupils, and their revival in contemporary economics. The first and last sections work together to illustrate the evolutionary focus of Marshall 's research program and to identify its affinity with modern industrial economics; the second explicates the social assumptions within which the Marshallian paradigm was embedded, in particular those relating to the various relationships that exist between individuals and wider groups; while the third traces the development of Marshall 's views by some of his pupils.

Drug development is risky business. It is against the backdrop of huge financial, scientific, technical and medical risks that a clinical trials manager is expected to function, effectively identifying and managing all project risks, to deliver a successful outcome. Focusing on the day-to-day needs of a clinical trials manager, Clinical Trials Risk Management explains the key concepts and principles of risk management, as well as showing how best to how to apply them directly to 'real life' clinical trial situations. After building a foundation of basic principles, the authors lead you through specific methods for handling the risks characteristically encountered in clinical trials. Their combined years of experience in pharmaceutical research and development shine through the narrative, making the prose both lively and informative. They discuss concepts using worked examples and include a summary of the main points at the end of each chapter. In addition to diagrams and Risk and Precision Tree charts, the text is sprinkled with humorous line drawings that reinforce the concepts. After reading this book, you will know how to: -Prepare a Risk Assessment -Design an Impact-Probability Matrix -Compile a Risk Register -Run a Monte Carlo Simulation -Set up a Project Decision Tree -Plan preventative and contingency actions The stand-alone chapters provide easy access to topics, while anecdotal and visual examples make them easy to remember. Martin Robinson and Simon Cook deliver a clear interpretation of complex information, thus saving you the time it would take to wade through a lengthier text, adopting a straightforward approach to examining clinical trials from a risk manager'sperspective. A practical, readable guide, the book is filled with information that can be put to immediate use to improve current or planned clinical trials.

Conventional wisdom says that the world is heading for a major water crisis. By 2050, global population will increase from 7 billion to a staggering 9.5 billion and the demands this will place on food and water systems will inevitably push river basins over the edge. The findings from this book present a different picture. While it is convenient to visualize an inevitable global water and food crisis in which increasing demands result in increasing poverty, food insecurity and conflict, the reality is far more nuanced and revolves around the politics of equitable and sustainable development of resources. The first part of this book provides detailed insight into conditions of water flows within nine river basins. In the second part, authors summarize and re-analyze the outcome of the nine basins, providing a coherent global picture of water, water productivity and development. They assess the impacts of variations of these attributes on development and approaches for poverty alleviation, and explore the institutional factors that support or obstruct change. How people will manage river systems while protecting vital ecosystem functions will make the difference between catastrophe and survival. As Prof Asit Biswas points out, "... the world is facing a water crisis not because of physical scarcity of water but because of poor management practices in nearly all countries of the world." The book is based on the four years (2006-2010) of extensive research into the state of ten of the world's major river basins carried out under the CGIAR Challenge Program for Water and Food's Basin Focal Project. This book was published as a special issue of Water International.

Covers the principles of Good Clinical Practice Guidelines Contains case histories that illustrate successes and discusses how to get a project back on track Integrates R&D into the clinical study sequence and models how to write a study protocol Offers anecdotal and visual examples with easy-to-remember reference points Presents a comprehensive overview of the drug development process and the trends that are driving change Includes analysis of interactions between sponsors and CROs and a profile of the ideal project manager What if you were suddenly in charge? After the initial excitement of a "battlefield promotion" wears off, you need to get in the trenches and get the job done. And if you are already in the trenches, you need quick access to information that will make your job easier. A comprehensive desk reference and guide, Clinical Studies Management: A Practical Guide to Success provides the practical skills and methods required by project managers running clinical studies. The author explains a framework for project management based on seven core themes: goals, budgets, time, resources, measurement, communication, and training. He solidly reviews how modern management theory can be brought to bear on the specialized demands of clinical trials. The book covers the practical how-tos of writing and costing a study, organizing an Investigator Meeting, and improving patient enrollment in your study. Divided into stand-alone chapters that make the information easy to find, the book presents a comprehensive overview of drug development processes and the trends that are driving change. If you are new to study management, the book rapidly brings you up to speed. If you are an experienced study manager, it gives you a convenient and authoritative reference you will use on a daily basis. Whatever your level of experience, Clinical Studies Management: A Practical Guide to Success supplies the tools you need to manage your projects ef

A new perspective on a book that transformed Victorian illustration into a stand-alone art. Edward Moxon's 1857 edition of Alfred, Lord Tennyson's Poems dramatically redefined the relationship between images and words in print. Cooke's study, the first book to address the subject in over 120 years, presents a sweeping analysis of the illustrators and the complex and challenging ways in which they interpreted Tennyson's poetry. This book considers the volume's historical context, examining in detail the roles of publisher, engravers, and binding designer, as well as the material difficulties of printing its fine illustrations, which recreate the effects of painting. Arranged thematically and reproducing all the original images, the chapters present a detailed reappraisal of the original volume and the distinctive culture that produced it.

Thomas Pynchon's fiction has been considered masculinist, misogynist, phallocentric, and pornographic: its formal experimentation, irony, and ambiguity have been taken both to complicate such judgments and to be parts of the problem. To the present day, deep critical divisions persist as to whether Pynchon's representations of women are sexist, feminist, or reflective of a more general misanthropy, whether his writing of sex is boorishly pornographic or effectually transgressive, whether queer identities are celebrated or mocked, and whether his departures from realist convention express masculinist elitism or critique the gendering of genre. Thomas Pynchon, Sex, and Gender reframes these debates. As the first book-length investigation of Pynchon's writing to put the topics of sex and gender at its core, it moves beyond binary debates about whether to see Pynchon as liberatory or conservative, instead examining how his preoccupation with sex and gender conditions his fiction's whole worldview. The essays it contains, which cumulatively address all of Pynchon's novels from V. (1963) to Bleeding Edge (2013), investigate such topics as the imbrication of gender and power, sexual abuse and the writing of sex, the gendering of violence, and the shifting representation of the family. Providing a wealth of new approaches to the centrality of sex and gender in Pynchon's work, the collection opens up new avenues for Pynchon studies as a whole.

Conventional wisdom says that the world is heading for a major water crisis. By 2050, global population will increase from 7 billion to a staggering 9.5 billion and the demands this will place on food and water systems will inevitably push river basins over the edge. The findings from this book present a different picture. While it is convenient to visualize an inevitable global water and food crisis in which increasing demands result in increasing poverty, food insecurity and conflict, the reality is far more nuanced and revolves around the politics of equitable and sustainable development of resources. The first part of this book provides detailed insight into conditions of water flows within nine river basins. In the second part, authors summarize and re-analyze the outcome of the nine basins, providing a coherent global picture of water, water productivity and development. They assess the impacts of variations of these attributes on development and approaches for poverty alleviation, and explore the institutional factors that support or obstruct change. How people will manage river systems while protecting vital ecosystem functions will make the difference between catastrophe and survival. As Prof Asit Biswas points out, "... the world is facing a water crisis not because of physical scarcity of water but because of poor management practices in nearly all countries of the world." The book is based on the four years (2006-2010) of extensive research into the state of ten of the world's major river basins carried out under the CGIAR Challenge Program for Water and Food's Basin Focal Project. This book was published as a special issue of Water International.