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This volume provides a set of reviews dedicated to the biology
of Interleukin (IL)-10. It includes chapters on its importance for
maintaining immune homeostasis in humans, its role in intestinal
immunity and its functions during viral and bacterial infections.
In addition, it presents reviews on the mechanisms linking innate
microbial recognition to the production of IL-10 and on how IL-10
recognition by its receptor functions. The roles of T and B cells
as relevant sources of IL-10 are also discussed, with an emphasis
on the clinical opportunities offered by IL-10-producing Tr1 cells
for the suppression of unwanted immunity. Finally, the functions of
other cytokines of the IL-10 family are presented. Collectively,
these articles provide a comprehensive overview of our current
knowledge on one of the most important anti-inflammatory cytokines
known to date.
This volume provides a set of reviews dedicated to the biology of
Interleukin (IL)-10. It includes chapters on its importance for
maintaining immune homeostasis in humans, its role in intestinal
immunity and its functions during viral and bacterial infections.
In addition, it presents reviews on the mechanisms linking innate
microbial recognition to the production of IL-10 and on how IL-10
recognition by its receptor functions. The roles of T and B cells
as relevant sources of IL-10 are also discussed, with an emphasis
on the clinical opportunities offered by IL-10-producing Tr1 cells
for the suppression of unwanted immunity. Finally, the functions of
other cytokines of the IL-10 family are presented. Collectively,
these articles provide a comprehensive overview of our current
knowledge on one of the most important anti-inflammatory cytokines
known to date.
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