In the present work, floating microspheres of AZH were formulated to provide site specific delivery of drug with a view to providing an effective and safe therapy for eradication of H.pylori with a reduced dose and reduced duration of therapy. The developed floating microspheres of AZH have excellent buoyant ability, high encapsulation and good release pattern. The slow but complete drug release in the stomach is expected to increase bioavailability of the drug as well its complete utilization which may results to lower dose and GI side effects. It can be concluded that optimized multi-unit floating AZH microspheres floating more than 8 hrs in stomach. The floating microsphere is a potential system for delivery of AZH in the stomach. So it is expected to provide clinicians with a new choice of an economical, safe and low dose formulation in the management of eradication of H.pylori.