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Dopamine receptors (DRs) belong to the class A of G-protein coupled
receptors (GPCRs) super family. The five subtypes of dopamine
receptors (DRs) i.e. D1R, D2R, D3R, D4R and D5R have been
characterized and classified in D1-like (D1R and D5R; stimulatory)
and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on
their sequence similarities and physiological response. The DRs are
involved in many physiological processes and thus, deregulation in
their activity led to the various mental disorders. Therefore, the
DRs are attractive targets for the development of new drug
molecules for the treatment of various CNS disorders. This book
describes the development and validation of 3D structure model for
all DR isoforms. The 3D structure model of DRs may be used in
docking study to identify crucial amino acid residues involved
Drug-Receptor interactions. This is turn, will contribute in the
designing of novel DR agonists and antagonists. This is also
helpful to understand the mechanism of activation and inhibition of
these receptors. Also, the docking models will be useful In Silico
activity prediction of new compounds as well as in virtual
screening to identify new lead molecules.
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