Smart Design, Science & Technology represents the proceedings of the IEEE 6th International Conference on Applied System Innovation (ICASI 2020), which was held in Taitung, Taiwan November 5-8, 2020. The conference received more than 200 submitted papers from at least 11 different countries, whereby roughly one third of these papers was selected by the committees and invited to present at ICASI 2020. This book aims to provide an integrated communication platform for researchers from a wide range of disciplines including information technology, communication science, applied mathematics, computer science, advanced material science, and engineering. Only high quality papers were allowed to publish in the volume. Hopefully, interdisciplinary collaborations between science and engineering technologists in academia and industry will be enhanced via this unique international network.