The last Kindling Conference was organized by Dr. Juhn Wada and held at the Univer sity of British Columbia, Vancouver, B. C. , in 1989. In the intervening years, research on kin dling has proceeded at an explosive pace and significant advances have been made in our understanding of the molecular biological, anatomical, and physiological substrates of kin dling, as well as in our appreciation of the age-dependent effects and complex behavioral consequences of kindling, its sensitivity to drugs, and its relevance to the clinical epilepsies. In order to review these developments and to provide researchers with an opportunity to in teract face to face and discuss the issues that preoccupy us all, we organized the Fifth Interna tional Conference on Kindling, in Victoria, B. C. , in the summer of 1996. Most of the stalwarts in kindling research were invited, as were a number of investigators whose research on kindling has become prominent in the past few years. We continue to miss the late Graham Goddard, the discoverer of kindling, and were saddened by the recent death of Eric Lothman, a prolific researcher and clinician who would have been a prominent participant. We were deeply disturbed to learn of the death of Frank Morrell, one of the earliest kindlers and an eminent neurologist, who died several months after our conference.

Proceedings of the Sixth International Conference on Kindling, featuring valuable summaries of the participants current cutting-edge research on the kindling of seizures and related phenomena in epilepsy.

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals.

Much has been written about the cognitive function of children with epilepsy but despite there being extensive study of the neuropsychological status of adults with intractable temporal lobe epilepsy, it has been more limited in children. Although cognitive development in children is influenced by similar factors to adults, the role of early damage, modification of cerebral organisation and interruption of the learning process are also likely to be important. Devoted to cognitive function and dysfunction in children with temporal lobe epilepsy, this book highlights those domains that demand further research and those for which immediate established techniques for a better global care can be undertaken.

Proceedings of the Sixth International Conference on Kindling, featuring valuable summaries of the participants current cutting-edge research on the kindling of seizures and related phenomena in epilepsy.

Stay current with recent progress in the field of acute encephalopathy and encephalitis in infants with this practical resource by Drs. Hideo Yamanouchi, Solomon L. Moshe, and Akihisa Okumura. This practical resource covers key information relevant to physicians, surgeons, and nurses who often must take prompt action in the everyday clinical care of patients with these disorders. Features a wealth of information for all health care professionals who encounter these complex conditions. Covers diagnostic strategy, subtypes of acute encephalopathy, and management of acute encephalopathy and encephalitis. Consolidates today's available information and guidance on acute encephalopathy and encephalitis in infancy, in addition to related disorders, into one convenient resource.

Keynote Adress. Genetic Predisposition and Kindling Susceptibility in Primates; J.A. Wada. Developmental Patterns. Idiosyncrasies of Limbic Kindling in Developing Rats; K.Z. Haas, et al. Long-Term Effects of Kindling on Learning and Memory in the Developing Brain; M. Sarkisian, et al. Electrophysiological Mechanisms. Long-Lasting Prolongation of NMDA Channel Openings after Kindling; I. Mody, D.N. Lieberman. Morphological and Anatomical Mechanisms. Role of Rhinencephalic Networks in Early Stage Kindling; J.L. Burchfiel. Synaptic Pharmacology and Neurochemistry of Kindling. Regionally Specific Changes in Glatamate and GABAA Receptors, PKC Isozymes, and Ionic Channels in Kindling Epileptogenesis of the Hippocampus of the Rat; F.H. Lopes da Silva, et al. Behavioral Effects of Kindling. Amygdala Kindling and Rodent Anxiety; R. Adamec. Drugs and Kindling. Protective Effect of Brain-Derived Neurotrophic Factor in Hippocampal Kindling; S. Reybiel. Clinical Implications of Kindling. The Syndrome of Mesial Temporal Lobe Epilepsy: A Role for Kindling; J. Engel. 27 additional articles. Index.