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Metabolic and Cellular Engineering (MCE) is more than an exciting
scientific enterprise. It has become the cornerstone for coping
with the challenges ahead of mankind. Continuous developments, new
concepts, and technological innovations will enable us to deal with
emerging challenges, and solve problems once thought impossible ten
years ago. Challenges in MCE are broad- from unraveling fundamental
aspects of cellular function to meeting unsatiated energy and food
demands that are rising in parallel with population growth.In
charting the progress of MCE during the last decade, we could not
help but feel in awe of the enormous strides of progress made from
the nascent Metabolic Engineering to the Systems Bioengineering of
today. The burgeoning availability of genomic sequences from
diverse species has been spectacular. It has become the engine that
drives the genetic means for the modification of existing organisms
and the generation of synthetic, man-made ones. From the initial
attempts at purposeful genetic modification of a cell for the
production of valuable compounds, we have now moved on to changing
microbes genetically or metabolically.The arsenal of experimental
and theoretical tools available for Metabolic and Cellular
Engineering has expanded enormously, driven by the re-emergence of
Physiology as Systems Biology. The revival of the concept of
networks fueled by new developments has become central to Systems
Biology. Networks represent an integrative vision of how processes
of disparate nature relate to each other, and as such is becoming a
key analytical and conceptual tool for MCE. This book reflects and
addresses all these ongoing changes while providing the essential
conceptual and analytical tools needed to understand and work in
the MCE research field.
Metabolic and Cellular Engineering (MCE) is more than an exciting
scientific enterprise. It has become the cornerstone for coping
with the challenges ahead of mankind. Continuous developments, new
concepts, and technological innovations will enable us to deal with
emerging challenges, and solve problems once thought impossible ten
years ago. Challenges in MCE are broad- from unraveling fundamental
aspects of cellular function to meeting unsatiated energy and food
demands that are rising in parallel with population growth.In
charting the progress of MCE during the last decade, we could not
help but feel in awe of the enormous strides of progress made from
the nascent Metabolic Engineering to the Systems Bioengineering of
today. The burgeoning availability of genomic sequences from
diverse species has been spectacular. It has become the engine that
drives the genetic means for the modification of existing organisms
and the generation of synthetic, man-made ones. From the initial
attempts at purposeful genetic modification of a cell for the
production of valuable compounds, we have now moved on to changing
microbes genetically or metabolically.The arsenal of experimental
and theoretical tools available for Metabolic and Cellular
Engineering has expanded enormously, driven by the re-emergence of
Physiology as Systems Biology. The revival of the concept of
networks fueled by new developments has become central to Systems
Biology. Networks represent an integrative vision of how processes
of disparate nature relate to each other, and as such is becoming a
key analytical and conceptual tool for MCE. This book reflects and
addresses all these ongoing changes while providing the essential
conceptual and analytical tools needed to understand and work in
the MCE research field.
Metabolic and cellular engineering, as presented in this book, is a
powerful alliance of two technologies: genetics -- molecular
biology and fermentation technology. Both are driven by continuous
refinement of the basic understanding of metabolism, physiology and
cellular biology (growth, division, differentiation), as well as
the development of new mathematical modeling techniques. The
authors' approach is original in that it integrates several
disciplines into a coordinated scheme, i.e. microbial physiology
and bioenergetics, thermodynamics and enzyme kinetics,
biomathematics and biochemistry, genetics and molecular biology.
Thus, it is called a transdisciplinary approach (TDA). The TDA
provides the basis for the rational design of microorganisms or
cells in a way that has rarely been utilized to its full extent.
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