This book constitutes the post-conference proceedings of the First MICCAI Workshop on Medical Applications with Disentanglements, MAD 2022, held in conjunction with MICCAI 2022, in Singapore, on September22, 2022. The 8 full papers presented in this book together with one short paper were carefully reviewed and cover generative adversarial networks (GAN), variational autoencoders (VAE) and normalizing-flow architectures as well as a wide range of medical applications, like brain age prediction, skull reconstruction and unsupervised pathology disentanglement.

This book constitutes the refereed proceedings of the Second International Workshop on Simulation and Synthesis in Medical Imaging, held in conjunction with MICCAI 2017, in Quebec City, Canada, in September 2017. The 11 revised full papers presented were carefully reviewed and selected from 14 submissions. The contributions span the following broad categories: cross modality (PET/MR, PET/CT, CT/MR, etc.) image synthesis, simulation and synthesis from large-scale image databases, automated techniques for quality assessment images, and several applications of image synthesis and simulation in medical imaging such as image interpolation and segmentation, image reconstruction, cell imaging, and blood flow.

This book constitutes the refereed proceedings of the First International Workshop on Simulation and Synthesis in Medical Imaging, held in conjunction with MICCAI 2016, in Athens, Greece, in October 2016. The 17 revised full papers presented together in this book were carefully reviewed and selected from 21 submissions. The contributions span the following broad categories: fundamental methods for image-based biophysical modeling and image synthesis; biophysical and data-driven models of disease progression or organ development; biophysical and data-driven models of organ motion and deformation; biophysical and data-driven models of image formation and acquisition; segmentation/registration across or within modalities to aid the learning of model parameters; cross modality (PET/MR, PET/CT, CT/MR, etc.) image synthesis; simulation and synthesis from large-scale image databases; automated techniques for quality assessment of simulations and synthetic images; as well as several applications of image synthesis and simulation in medical imaging such as image registration and segmentation; image denoising and information fusion; image reconstruction from sparse data or sparse views; and real-time simulation of biophysical properties. The papers were divided into two general topics named "simulation based approaches for medical imaging" and "synthesis and its applications in computational medical imaging".