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The serendipitously discovered link between developmental biology
and cancer, touched of an explosion of discoveries on the role of
Notch in human malignancies, including every aspect of cancer
biology, from control of differentiation, proliferation and
apoptosis in transformed cells to angiogenesis, tumor-stroma
interaction and anti-cancer immune responses. A number of
observations have revealed that Notch even plays a role in the
renewal of cancer stem cells and tumor initiating cells, which are
thought to be a major cause of resistance to treatment. Targeting
Notch in Cancer will provide researchers, oncologists,
pharmacologists and students with a detailed understanding of the
intricate cross-talk between Notch and other pathways of
therapeutic interest so to better design rational drug combinations
for specific diseases and disease subsets. Divided into two parts,
Part I describes in detail what we know about the genetics,
molecular biology, biochemistry and structural biology of Notch, as
well as the role of Notch in such processes as angiogenesis and
immune surveillance. Without insights gained from these basic
studies, rational targeting of Notch in human disease would be
impossible. Part II describes the role of Notch and ongoing
experimental therapeutic efforts in the most important subtypes of
human cancers, organized in a clinically oriented fashion by organs
and systems affected
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Richard III
Jacob Abbott
Hardcover
R483
Discovery Miles 4 830
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