Alcohol abuse remains a significant problem world-wide. The most commonly affected organ remains the liver with a risk of alcoholic liver disease (ALD) which can range from asymptomatic to alcoholic hepatitis to alcoholic cirrhosis. In 2010, alcohol-attributable cirrhosis was responsible for 0.9% of all global deaths. Given the sheer magnitude of alcohol abuse and alcoholic liver disease, an update on this topic is pertinent and relevant. This issue will focus on a variety of topics including alcoholism, the pathogenesis of ALD, the spectrum of ALD, the pathology of ALD, and the long-term management of patients with ALD. Alcoholic hepatitis is a particular type of ALD with a high mortality. This issue will explore the syndrome of alcoholic hepatitis, its prognostic markers, and the available therapies. Because alcohol intake can influence so many other conditions of the liver (especially hepatitis C), articles in this issue will also explore the impact of alcohol abuse on other liver conditions. In addition, several other topics such as nutritional therapy for ALD, ALD and liver cancer, and ALD and infection risk will be explored. Also, even though it is quite controversial, we will also explore liver transplant as a therapy for alcoholic liver disease including alcoholic hepatitis.

Left-handedness has been shown to be a possible marker for various psychological and physical abnormalities. This book presents evidence by a number of researchers who evaluate whether there are indeed differences between left- and right-handers which extend into the broader psychological and physiological realms. Several chapters show that left-handedness is found in unexpectedly high proportions in populations that suffer from various immune deficiency diseases, in alcoholics, dyslexics, mental retardates, psychopaths and other clinical groups. The book indicates why left-handedness should be a marker for such conditions. The genetic and environmental pressures on handedness are explored. A model for pathological left-handedness is presented, along with some interesting data which suggests that left-handedness may be associated with reduced life-span. Finally, several chapters discuss the implications of handedness patterns in non-clinical populations.

Artificial Intelligence in Pathology: Principles and Applications provides a strong foundation of core artificial intelligence principles and their applications in the field of digital pathology. This is a reference of current and emerging use of AI in digital pathology as well as the emerging utility of quantum artificial intelligence and neuromorphic computing in digital pathology. It is a must-have educational resource for lay public, researchers, academicians, practitioners, policymakers, key administrators, and vendors to stay current with the shifting landscapes within the emerging field of digital pathology. It is also of use to workers in other diagnostic imaging areas such as radiology. This resource covers various aspects of the use of AI in pathology, including but not limited to the basic principles, advanced applications, challenges in the development, deployment, adoption, and scalability of AI-based models in pathology, the innumerous benefits of applying and integrating AI in the practice of pathology, ethical considerations for the safe adoption and deployment of AI in pathology.

The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor."

From sexual fantasies to holidays this marvellous book charts our escape attempts. In a series of dazzling commentaries the authors reveal the ordinary and extraordinary ways in which we seek to defy the despair of the breakfast table and the office But the book is much more than a first-rate cartography of everyday life. It crackles with important theoretical insights about how `normality' is managed. This fully revised edition contains a superb new introduction, `Life After Postmodernism', which exposes the conceits of the postmodernist adventure and which should be required reading for anyone interested in making sense of everyday life.

From sexual fantasies to holidays this marvellous book charts our escape attempts. In a series of dazzling commentaries the authors reveal the ordinary and extraordinary ways in which we seek to defy the despair of the breakfast table and the office But the book is much more than a first-rate cartography of everyday life. It crackles with important theoretical insights about how `normality' is managed. This fully revised edition contains a superb new introduction, `Life After Postmodernism', which exposes the conceits of the postmodernist adventure and which should be required reading for anyone interested in making sense of everyday life.

eBook available with sample pages: 0203205545

'Richly documented and convincingly presented' -- New Society Mods and Rockers, skinheads, video nasties, designer drugs, bogus asylum seeks and hoodies. Every era has its own moral panics. It was Stanley Cohen's classic account, first published in the early 1970s and regularly revised, that brought the term 'moral panic' into widespread discussion. It is an outstanding investigation of the way in which the media and often those in a position of political power define a condition, or group, as a threat to societal values and interests. Fanned by screaming media headlines, Cohen brilliantly demonstrates how this leads to such groups being marginalised and vilified in the popular imagination, inhibiting rational debate about solutions to the social problems such groups represent. Furthermore, he argues that moral panics go even further by identifying the very fault lines of power in society. Full of sharp insight and analysis, Folk Devils and Moral Panics is essential reading for anyone wanting to understand this powerful and enduring phenomenon. Professor Stanley Cohen is Emeritus Professor of Sociology at the London School of Economics. He received the Sellin-Glueck Award of the American Society of Criminology (1985) and is on the Board of the International Council on Human Rights. He is a member of the British Academy.

Recent advances in computational algorithms, along with the advent of whole slide imaging as a platform for embedding artificial intelligence (AI), are transforming pattern recognition and image interpretation for diagnosis and prognosis. Yet most pathologists have just a passing knowledge of data mining, machine learning, and AI, and little exposure to the vast potential of these powerful new tools for medicine in general and pathology in particular. In Artificial Intelligence and Deep Learning in Pathology, Dr. Dr. Stanley Cohen, with a team of experts, covers the nuts and bolts of all aspects of machine learning, up to and including AI, bringing familiarity and understanding to pathologists at all levels of experience. Focuses heavily on applications in medicine, especially pathology, making unfamiliar material accessible and avoiding complex mathematics whenever possible. Covers digital pathology as a platform for primary diagnosis and augmentation via deep learning, whole slide imaging for 2D and 3D analysis, and general principles of image analysis and deep learning. Discusses and explains recent accomplishments such as algorithms used to diagnose skin cancer from photographs, AI-based platforms developed to identify lesions of the retina, using computer vision to interpret electrocardiograms, identifying mitoses in cancer using learning algorithms vs. signal processing algorithms, and many more.

The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor."

During the 1960s, traditional thinking about crime and its punishment, deviance and its control, came under radical attack. The discipline of criminology split into feuding factions, and various schools of thought emerged, each with quite different ideas about the nature of the crime problem and its solutions. These differences often took political form, with conservative, liberal, and radical supporters, and the resulting controversies continue to reverberate throughout the fields of criminology and sociology, as well as related areas such as social work, social policy, psychiatry, and law. Stanley Cohen has been at the center of these debates in Britain and the United States. This volume is a selection of his essays, written over the past fifteen years, which contribute to and comment upon the major theoretical conflicts in criminology during this period. Though associated with the "new" or radical criminology, Cohen has always been the first to point out its limitations--particularly in translating its theoretical claims into real world applications. His essays cove a wide range of topics-political crime, the nature of individual responsibility, the implications of new theories for social work practice, models of crime used in the Third World, banditry and rebellion, and the decentralization of social control. Also included is a previously unpublished paper on how radical social movements such as feminism deal with criminal law. Many criminology textbooks present particular theories or research findings. This book uniquely reviews the main debates of the last two decades about just what the role and scope of the subject should be.

While crime, law, and punishment are subjects that have everyday meanings not very far from their academic representations, "social control" is one of those terms that appear in the sociological discourse without any corresponding everyday usage. This concept has a rather mixed lineage. "After September 11" has become a slogan that conveys all things to all people but carries some very specific implications on interrogation and civil liberties for the future of punishment and social control.

The editors hold that the already pliable boundaries between ordinary and political crime will become more unstable; national and global considerations will come closer together; domestic crime control policies will be more influenced by interests of national security; measures to prevent and control international terrorism will cast their reach wider (to financial structures and ideological support); the movements of immigrants, refugees, and asylum seekers will be curtailed and criminalized; taken-for-granted human rights and civil liberties will be restricted. In the midst of these dramatic social changes, hardly anyone will notice the academic field of "punishment and social control" being drawn closer to political matters.

Criminology is neither a "pure" academic discipline nor a profession that offers an applied body of knowledge to solve the crime problem. Its historical lineage has left an insistent tension between the drive to understand and the drive to be relevant. While the scope and orientation of this new second edition remain the same, in recognition of the continued growth and diversity of interest in punishment and social control, new chapters have been added and several original chapters have been updated and revised.

'Richly documented and convincingly presented' -- New Society

Mods and Rockers, skinheads, video nasties, designer drugs, bogus asylum seeks and hoodies. Every era has its own moral panics. It was Stanley Cohen's classic account, first published in the early 1970s and regularly revised, that brought the term 'moral panic' into widespread discussion. It is an outstanding investigation of the way in which the media and often those in a position of political power define a condition, or group, as a threat to societal values and interests. Fanned by screaming media headlines, Cohen brilliantly demonstrates how this leads to such groups being marginalised and vilified in the popular imagination, inhibiting rational debate about solutions to the social problems such groups represent. Furthermore, he argues that moral panics go even further by identifying the very fault lines of power in society.

Full of sharp insight and analysis, Folk Devils and Moral Panics is essential reading for anyone wanting to understand this powerful and enduring phenomenon.

Professor Stanley Cohen is Emeritus Professor of Sociology at the London School of Economics. He received the Sellin-Glueck Award of the American Society of Criminology (1985) and is on the Board of the International Council on Human Rights. He is a member of the British Academy.

During the 1960s, traditional thinking about crime and its punishment, deviance and its control, came under radical attack. The discipline of criminology split into feuding factions, and various schools of thought emerged, each with quite different ideas about the nature of the crime problem and its solutions. These differences often took political form, with conservative, liberal, and radical supporters, and the resulting controversies continue to reverberate throughout the fields of criminology and sociology, as well as related areas such as social work, social policy, psychiatry, and law. Stanley Cohen has been at the center of these debates in Britain and the United States. This volume is a selection of his essays, written over the past fifteen years, which contribute to and comment upon the major theoretical conflicts in criminology during this period. Though associated with the "new" or radical criminology, Cohen has always been the first to point out its limitations particularly in translating its theoretical claims into real world applications. His essays cove a wide range of topics-political crime, the nature of individual responsibility, the implications of new theories for social work practice, models of crime used in the Third World, banditry and rebellion, and the decentralization of social control. Also included is a previously unpublished paper on how radical social movements such as feminism deal with criminal law. Many criminology textbooks present particular theories or research findings. This book uniquely reviews the main debates of the last two decades about just what the role and scope of the subject should be.