Stemming from a 2012 conference entitled Brain Degenerations and Emerging Mental Health Challenges in Sub-Saharan Africa, this book is aimed at both the general practitioner interested in CNS disorders, and the specialist who would like to know more about CNS pathology in Africa. By employing a broad defi nition of what brain degeneration means, the authors are able to touch upon everything from dementias and CNS malignancy to traumatic brain injury and CNS infective processes. This book draws from and builds upon the original conference presentations, and incorporates the most up-to-date science behind brain degeneration as well as actual case reports. Each of the book's six sections off er the reader a deeper understanding of brain degeneration as it exists in Sub-Saharan Africa.

In this day where research grants are the primary focus, many young investigators are thrown into neurosciences courses without any prior preparation in neuroanatomy. This book is designed to help prepare them by introducing many of the fundamentals of the nervous system. It represents the essentials of an upper level biology course on the central nervous system. It is not designed to be a clinical approach to the nervous system, but rather it approaches the nervous system from a basic science perspective that intertwines both structure and function as an organizing teaching and learning model. Medical and dental examples are included but the main focus is on neuroscience.

INTEGRATED NEUROSCIENCES This textbook takes as a premise that, in order to make intelligent diagnosis and provide a rational treatment in disorders of the nervous system, it is necessary to develop the capacity to answer the basic questions of clinical neurology: (1) Where is the disease process located? (2) What is the nature of the disease process? The purpose of this textbook is to enable the medical student to acquire the basic information of the neurosciences and neurology and most importantly the ability to apply that information to the solution of clinical problems. The authors also suggest that hospital trips be a part of any Clinical Neurosciences Course so that the student can put into actual practice what he has learned in the classroom. We believe that this textbook will be of value to the student throughout the four years of the medical school curriculum. Medical, psychiatry and neurology residents may also find this text of value as an introduction or review. It is more true in neurology than in any other system of medicine that a firm knowledge of basic science material, that is, the anatomy, physiology and pathology of the nervous system, enables the student and physician to readily arrive at the diagnosis of where the disease process is located and the nature of the most likely pathology. Subsequently that knowledge may be applied to problem solving in clinical situations.

INTEGRATED NEUROSCIENCES This textbook takes as a premise that, in order to make intelligent diagnosis and provide a rational treatment in disorders of the nervous system, it is necessary to develop the capacity to answer the basic questions of clinical neurology: (1) Where is the disease process located? (2) What is the nature of the disease process? The purpose of this textbook is to enable the medical student to acquire the basic information of the neurosciences and neurology and most importantly the ability to apply that information to the solution of clinical problems. The authors also suggest that hospital trips be a part of any Clinical Neurosciences Course so that the student can put into actual practice what he has learned in the classroom. We believe that this textbook will be of value to the student throughout the four years of the medical school curriculum. Medical, psychiatry and neurology residents may also find this text of value as an introduction or review. It is more true in neurology than in any other system of medicine that a firm knowledge of basic science material, that is, the anatomy, physiology and pathology of the nervous system, enables the student and physician to readily arrive at the diagnosis of where the disease process is located and the nature of the most likely pathology. Subsequently that knowledge may be applied to problem solving in clinical situations.

The purpose of this textbook is to enable a Neuroscientist to discuss the structure and functions of the brain at a level appropriate for students at many levels of study including undergraduate, graduate, dental or medical school level. It is truer in neurology than in any other system of medicine that a firm knowledge of basic science material, that is, the anatomy, physiology and pathology of the nervous system, enables one to readily arrive at the diagnosis of where the disease process is located and to apply their knowledge at solving problems in clinical situations. The authors have a long experience in teaching neuroscience courses at the first or second year level to medical and dental students and to residents in which clinical information and clinical problem solving are integral to the course.

Integrated Neuroscience argues that in order to make an intelligent diagnosis and provide a rational treatment nervous system disorders, it is necessary to answer the basic questions of clinical neurology. Where is the disease process located, and what is the nature of the disease process? For students to answer these questions, the authors first review the makeup of the cells within the central nervous system and the development of the regions within the central nervous system. A detailed anatomical overview of the nervous system, starting at the spinal cord, proceeding to the brain stem, diencephalon and cerebrum follows. This textbook focuses not only on localized diseases caused by infectious diseases, trauma, tumors, and vascular lesions within the central nervous system, but also these diseases within the systems of the brain and spinal cord. Over 250 real cases with associated MRI or CTs and any pathological findings from these patients illustrate numerous disorders and fully explain the nature of the pathology. The authors have also included six problem solving sessions in which the student must identify the ongoing disease process, what caused it, and how best to treat it. Throughout the discussion in this text the authors also correlate the neurological findings to the underlying anatomy of the region.

This five-session seminar, organized during 1946-47 for the psychiatric residents at Sheppard-Pratt, specifically covered the case of a young male schizophrenic who was being treated by Dr. Robert Kvarnes, then a participating resident. Each session included the case presentation by Dr. Kvarnes, the posing of a discussion question by Sullivan, his exchanges with the participants, and his extended closing comments on major clinical issues. The publication of this seminar provides a demonstration of Sullivan at work as a teacher. His unusual sensitivity to young male schizophrenics and his delicacy in perceiving and reacting to anxiety in therapeutic interactions are reflected in the seminar.

The contemporary discussions, conducted by Dr. Kvarnes, now director of the Washington School of Psychiatry, Washington, D.C., follow each of the original seminar sessions, consider the seminar content itself, and show the differences that twenty-five years have made in the various trends in therapy and in salient social programs. Also included is additional historical material about the seminar the participants, and Sullivan.