The vaccines most urgently needed are those againstpoverty-related diseases such as tuberculosis, malaria and HIV.However, there is a considerable gap between the development of avaccine and the implementation as a useful measure for diseasecontrol. Major obstacles need to be overcome even after successfulcompletion of the preclinical stage.

This book provides an important link between vaccine developmentand application under the particular conditions in developingcountries.
The editors, S.H.E. Kaufmann and P.H. Lambert - one from the fieldof basic research and the other an expert on the side of appliedvaccinology - have gathered contributions from specialists of bothfields in an attempt to create a source of information that hasthus far not been available.

Edited by Stefan H.E. Kaufmann and Michael W. Steward. Immunology brings together the scientific basis and clinical aspects of the acquisition and progression of the host response to infectious disease, providing comprehensive coverage of this fast-moving field. It is included in the tenth edition of Topley & Wilson's Microbiology and Microbial Infections as a stand-alone volume for the first time. Arranged under the topics of innate immunity and inflammation, soluble mediators, acquired immunity, infection and immunity, immunopathology, and immunodeficiency and vaccines, Immunology allows the reader to identify specific topics related to infectious diseases, and also to find information on the basic mechanisms underlying immunity. Chapters include information on the clinical issues of immunology as they relate to immunopathology and immunodeficiency, and on the different aspects of vaccination and vaccine development. The international authorship and breadth of coverage ensure that Immunology is an unrivalled resource for all members of the immunology community and associated microbiological disciplines, including research scientists, clinical laboratory scientists, infectious disease specialists and other clinicians. In addition, Immunology is an invaluable reference for students and teachers of immunology.

It has been said that the development of vaccines against a variety of infectious diseases is among the greatest triumphs of immunology. Indeed, several pathogens have lost their horror through the availability of effective vaccination measures. Unfortunately, this does not hold true for the pathogens dealt within this volume. Malaria, schistosomiasis, leishmaniasis, leprosy, and tuberculosis together are prevalent in more than 100 countries, and over 400 million persons suffer from these diseases. It is becoming increasingly clear that the failure to control these infections in a satisfactory way is directly related to the complexity oftheir interactions with the immune system. These agents have lived with their hosts for long enough to give both-host and parasite-ample opportunity to develop a highly sophisticated interrelationship. The central role of T lymphocytes both in acquired resistance to and pathogenesis of these microbes is well appreciated. In the beginning it may have been thought that acq uired resistance against infectious agents is nothing but another aspect of the immune response, studied with soluble and particulate antigens. This simple concept has gradually changed, and it has become clear that the viability not only of the immune cells but also of the 'antigens' adds another dimension to the game. Several achievements in cellular immunology and molecular biology have now made it possible to better understand at least some mechanisms in this intricate interplay.

Almost 30 years ago RITOSSA described a new puffing pattern in salivary gland chromosomes of Drosophila following heat shock. This was the first description of a heat shock response. For years, development in this field remained modest and it took another decade before the relevant gene products-the heat shock proteins (hsp's)-were made visible by TISSIERES and co-workers. Subsequently, progress advanced more rapidly and we can now state that studies on the heat shock response have contributed much to our understanding of various principles in molecular and cellular biology such as control of gene expression and regulation of protein translocation. More recently, the study of hsp's has converged with immunology. There are several reasons for this: The chaperone function of certain hsp's makes them particularly apt for central functions of immunity, including antigen presentation and immunoglobulin synthesis. Furthermore, an effective immune response is often caused or followed by stress situations as they arise during trauma, inflammation, transformation, infection, or autoimmune disease. Due to their abundance during stress, hsp's can provide prominent antigens in many of these situations. This volume contains 11 chapters written by well-known experts dealing with various facets of the fascinating liaison between hsp's and immunity. The particular relation of hsp's to the immune system may be best illustrated by their intimate association with the major histocompatibility gene complex. Still, as discussed by GONTHER, the relevance of this fact to our understanding of hsp functions in immunity remaif)s speculative.

Immunology of Infection, 2nd Edition, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the Microbiologist interested in analysing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology.
This new edition of Immunology of Infection provides ready-to-use "recipes," and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition.
Methods in Microbiologyis the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research.
Key Features:
* Includes techniques for genome-wide expression profiling of both the pathogen and host and of the host response to infection
* Cytometric analysis of cytokine secretion by immune cells
* Describes tetramer technology for the quantitative analysis of antigen specific T cell responses
* analysis of host cells and pathogens involved in the host-microbe interplay
* Covers techniques useful for the analysis of human and murine systems
* Includes techniques for the prediction and determination of MHC ligands and T cell epitopes
* Covers the fundamentals and practice of DNA vaccines
* Describes methods for the isolation and propagation of human dendritic cells

Established for almost 30 years, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research.
Immunology of Infection, edited by two of the foremost figures in the field, presents the most appropriate, up-to-date techniques in the detail you require. The layout is structured for ease of reference, and the volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology, and parasitology.
The new volume provides a carefully selected collection of immunological techniques for the microbiologist wishing to study host-pathogen relationships "in vivo" and "in vitro." This multi-authored book has succeeded in bringing together experts from various fields of molecular and cellular immunology who provide ready-to-use recipes for the "ex vivo" and "in vitro" analysis of anti-infective immunity.
Key Features
* Focuses on the methods most useful for the microbiologist interested in analysing host-pathogen relationships
* Ready-to-use, tried and tested recipes
* Lists of suppliers provided as appendices to each chapter
* Covers techniques useful for the analysis of human and murine cells
* Includes techniques for the prediction and determination of MHC ligands and T cell epitopes
* Describes the art and science of DNA vaccines
* Essential methods for measuring human cytokine responses
* Covers isolation and propagation of dendritic cells

Immunology of Infection, 3rd Edition, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the Microbiologist interested in analysing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology. This new edition of Immunology of Infection provides ready-to-use "recipes," and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition. Methods in Microbiologyis the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research.

In diesem Lehrbuch wird die medizinische Mikrobiologie von den allgemeinen Grundlagen uber die Immunologie, die Diagnostik bis hin zur Chemotherapie dargestellt. Dabei sind die Kapitel zu den einzelnen Erregern besonders ubersichtlich gestaltet. Um den klinischen Bezug deutlich zu machen, gibt es eine eigene grosse Sektion zu den Krankheitsbildern. Ein durchdachtes Konzept macht das Lernen leicht: Erreger-Steckbriefe zum schnellen Lernen Fallbeispiele Zusammenfassungen am Kapitelende Zahlreiche klinische Abbildungen Enge Vernetzung zwischen Erreger-Kapiteln und den Krankheitsbildern durch viele Querverweise Samtliche Teilbereiche des Fachgebietes sind enthalten: Grundlagen, Immunologie, Diagnostik, Epidemiologie, Pravention, Hygiene, Bakteriologie, Virologie, Mykologie, Parasitologie, Chemotherapie, wichtige Krankheitsbilder Die Herausgeber Professor Sebastian Suerbaum ist Vorstand des Lehrstuhls fur Medizinische Mikrobiologie und Krankenhaushygiene am Max von Pettenkofer-Institut der Ludwig-Maximilians-Universitat Munchen Professor Gerd-Dieter Burchard ist tatig im Bernhard-Nocht-Institut fur Tropenmedizin in Hamburg. Professor Thomas Schulz ist Direktor des Instituts fur Virologie der Medizinischen Hochschule Hannover Professor Stefan H.E. Kaufmann ist Direktor am Max-Planck-Institut fur Infektionsbiologie in Berlin.