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For a virus to invade a host cell it needs to penetrate the
physical barrier imposed by the plasma membrane. Viruses have
evolved specialized surface proteins to meet this challenge. These
proteins facilitate delivery of the viral genetic information into
the host cell by either fusing the viral envelope with a host cell
membrane or by forming membrane pores. Membrane fusion and pore
formation critically depend on the engagement of host cell
receptors and receptor choice is a key determinant of viral
tropism. The multi-faceted interplay between viral and cellular
factors during virus entry is a fascinating field of study, which
can provide important insight into viral pathogenesis and define
new targets for intervention. This book provides a comprehensive
overview of this exciting field of research.
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