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Neuroendocrine neoplasms comprise a large family of proliferative
lesions that involve almost every part of the body. Our
understanding of their cells of origin as well as the pathology,
pathophysiology and genetics of these neoplasms has made tremendous
advances in the last few decades. While they are often discussed as
separate entities in textbooks of gastroenteropancreatic pathology
and pulmonary pathology, their scope is much broader. The book
conveys the similarities and differences of these fascinating
tumors that may be found from the hypothalamus and pituitary to the
rectum, and in soft tissue as well as in many organs. Written by
experts in the field, the authors emphasize their structural,
functional, predictive and prognostic features and attempt to
provide the clinical context that allows improved diagnosis and
therapy while building on the genetics that clarifies patterns of
inheritance and predisposition to tumor development through
precursor lesions. The Spectrum of Neuroendocrine Neoplasia
provides a broad overview of neuroendocrine neoplasms using a
practical approach to diagnosis, histological classification and
therapy, and presents the most important and significant
developments of the technologies used to diagnose, classify and
treat them.
This book provides a broad overview of pancreatic neuroendocrine
neoplasms, focusing on the most important developments in the
technologies used to diagnose, classify and treat them. After a
historical and epidemiological overview, the opening chapters
examine the various diagnostic approaches (radiology, nuclear
medicine, endocrinology, cytology and immunohistochemistry) and
discuss the WHO classification. The functioning and nonfunctioning
tumor types are then fully discussed, covering epidemiology,
diagnosis, morphology and prognosis of each entity. Careful
consideration is given to the molecular features that have
contributed in understanding the pathogenesis of such neoplasms and
may have potential implications for the diagnostic and therapeutic
pathways. The final chapters consider the surgical and medical
approaches to therapy, providing a practical and analytical
overview of the available options. The book is written by a
multidisciplinary team of worldwide-recognized experts and is
addressed to radiologists, nuclear medicine physicians,
endocrinologists, pathologists, surgeons and oncologists.
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