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This volume aims to enhance the current understanding of clinical
features, treatment and pathogenic aspects in necrotizing soft
tissue infections. Various representative case studies are
discussed to enhance the readers' understanding of these complex
diseases. Necrotizing soft tissue infections are rapidly spreading
infections that may cause extensive soft tissue or limb loss,
multiorgan failure and are associated with a considerable fatality
rate. It is undisputed that rapid diagnosis and prompt intervention
is directly related to survival. The initial presentation may be
limited to unspecific symptoms such as tenderness, swelling,
erythema and pain. Thus, diagnosis and management are challenging
due to heterogeneity in clinical presentation, in co-morbidities,
in microbiological aetiology, as well as in the pathogenic
mechanisms. An international and multidisciplinary consortium,
INFECT, has for the last 6 years been pursuing research aimed to
advance the understanding of the clinical and pathogenic aspects of
these infections. A central part has been to create a comprehensive
clinical registry and associated biobank which have also formed the
basis for the experimental studies. Using the INFECT patient
cohort, as well as an integrated systems biology approach in
patients and clinically relevant experimental models, an advanced
insight of diagnostic features, causative microbial agents,
treatment strategies, and pathogenic mechanisms (host and bacterial
disease traits and their underlying interaction network) has been
obtained.
This volume aims to enhance the current understanding of clinical
features, treatment and pathogenic aspects in necrotizing soft
tissue infections. Various representative case studies are
discussed to enhance the readers' understanding of these complex
diseases. Necrotizing soft tissue infections are rapidly spreading
infections that may cause extensive soft tissue or limb loss,
multiorgan failure and are associated with a considerable fatality
rate. It is undisputed that rapid diagnosis and prompt intervention
is directly related to survival. The initial presentation may be
limited to unspecific symptoms such as tenderness, swelling,
erythema and pain. Thus, diagnosis and management are challenging
due to heterogeneity in clinical presentation, in co-morbidities,
in microbiological aetiology, as well as in the pathogenic
mechanisms. An international and multidisciplinary consortium,
INFECT, has for the last 6 years been pursuing research aimed to
advance the understanding of the clinical and pathogenic aspects of
these infections. A central part has been to create a comprehensive
clinical registry and associated biobank which have also formed the
basis for the experimental studies. Using the INFECT patient
cohort, as well as an integrated systems biology approach in
patients and clinically relevant experimental models, an advanced
insight of diagnostic features, causative microbial agents,
treatment strategies, and pathogenic mechanisms (host and bacterial
disease traits and their underlying interaction network) has been
obtained.
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