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This detailed book provides a laboratory manual and guidebook for
the selection, implementation, and interpretation of a wide range
of techniques in contemporary use in leading laboratories engaged
in Huntington's disease (HD) research worldwide. Only by
understanding the pathology and pathogenic process at the
fundamental molecular and cellular level can the research community
expect to be able to slow or halt the disease process, repair the
damage, and develop novel effective therapies to treat the symptoms
of this condition, thus this volume collects the practical
knowledge of its authors. Written for the highly successful Methods
in Molecular Biology series, chapters include introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and tips on troubleshooting and avoiding known pitfalls.
Authoritative and invaluable, Huntington's Disease aims to help
scientists to significantly extend the breadth and quality of
research in laboratories dedicated to mastering and controlling
this devastating human condition.
Movement is the way that animals interact with their environment
and is under the organization and complex control of the brain and
spinal cord. Multiple central nervous systems, including cortex,
basal ganglia, cerebellum, and brainstem, interact to provide
precise motor control and integration. Damage or disease within
these systems cause profound motor disturbances in man, which can
be effectively modeled in animals to develop a better understanding
and treatment of the human condition. Animal Models of Movement
Disorders introduces a variety of methods and techniques used to
model and assess motor function in experimental animals from lower
orders, such as drosophila and c. elegans, through vertebrate
species including fish, to mammals, such as rodents and non-human
primates. The most advanced contemporary models in each system are
presented at multiple levels of analysis from molecular and genetic
modeling, lesions, anatomy, neurochemistry, to imaging and
behavior. Volume I contains general methods of movement disorder
assessment as well as an extensive section on dopamine systems.
Comprehensive and meticulous, Animal Models of Movement Disorders
serves as a valuable reference for those studying motor disorders
by covering methodologies in detail and providing the information
necessary to consider both the appropriate models and assessment
tools that can most informatively answer the key experimental
issues in the field.
we might seek alternative sources of donor tissues. Genetic en-
neering, expansion of precursor cells, generation of immortalized
cell lines, and transplantation between species are all under
active investigation. Although significant difficulties remain for
each of these alternatives, the problems appear soluble and
relevant knowledge is expanding rapidly. As we enter the
twenty-first century, the place of neural tra- plantation in
experimental neuroscience is continuing to evolve. Rather than
being a topic in its own right, neural transplantation increasingly
serves as just another technique in the researcher's
armory--alongside lesions, pharmaceuticals, gene transfer, and a
variety of other techniques--for the experimental manipulation of
brain structure and function. This is particularly true for studies
of degeneration, plasticity, regeneration, and recovery of function
in the nervous system, topics of increasing importance as
experimental neurobiology is required to serve the higher needs of
neurological and mental health in aging societies. Within this
evolving context, Neural Transplantation Methods seeks to serve a
particular need: to provide experimental neu- scientists with a
source book of information to enable them to select and adapt
transplantation techniques to their own expe- mental programs. All
authors have been asked to address prac- cal issues, to enable the
reader to assess what is available, what are the alternatives, what
are the practical issues to be resolved in applying a particular
protocol and getting it to work reliably in their unique
experimental context.
Movement is the way that animals interact with their environment
and is under the organization and complex control of the brain and
spinal cord. Multiple central nervous systems, including cortex,
basal ganglia, cerebellum, and brainstem, interact to provide
precise motor control and integration. Damage or disease within
these systems cause profound motor disturbances in man, which can
be effectively modeled in animals to develop a better understanding
and treatment of the human condition. Animal Models of Movement
Disorders introduces a variety of methods and techniques used to
model and assess motor function in experimental animals from lower
orders, such as drosophila and c. elegans, through vertebrate
species including fish, to mammals, such as rodents and non-human
primates. The most advanced contemporary models in each system are
presented at multiple levels of analysis from molecular and genetic
modeling, lesions, anatomy, neurochemistry, to imaging and
behavior. Volume II of this detailed collection contains sections
on the basal ganglia, neo- and allo-cortical systems, cerebellar
and brain stem systems, as well as spinal cord systems.
Comprehensive and meticulous, Animal Models of Movement Disorders
serves as a valuable reference for those studying motor disorders
by covering methodologies in detail and providing the information
necessary to consider both the appropriate models and assessment
tools that can most informatively answer the key experimental
issues in the field.
we might seek alternative sources of donor tissues. Genetic en-
neering, expansion of precursor cells, generation of immortalized
cell lines, and transplantation between species are all under
active investigation. Although significant difficulties remain for
each of these alternatives, the problems appear soluble and
relevant knowledge is expanding rapidly. As we enter the
twenty-first century, the place of neural tra- plantation in
experimental neuroscience is continuing to evolve. Rather than
being a topic in its own right, neural transplantation increasingly
serves as just another technique in the researcher's
armory--alongside lesions, pharmaceuticals, gene transfer, and a
variety of other techniques--for the experimental manipulation of
brain structure and function. This is particularly true for studies
of degeneration, plasticity, regeneration, and recovery of function
in the nervous system, topics of increasing importance as
experimental neurobiology is required to serve the higher needs of
neurological and mental health in aging societies. Within this
evolving context, Neural Transplantation Methods seeks to serve a
particular need: to provide experimental neu- scientists with a
source book of information to enable them to select and adapt
transplantation techniques to their own expe- mental programs. All
authors have been asked to address prac- cal issues, to enable the
reader to assess what is available, what are the alternatives, what
are the practical issues to be resolved in applying a particular
protocol and getting it to work reliably in their unique
experimental context.
Functional Neural Transplantation IV: Translation to Clinical
Application, Volume 230 provides the current status of cell
transplantation in the nervous system, with a focus on the
conditions for achieving structural repair and functional recovery
after brain damage or in neurodegenerative disease. New to this
release are chapters that delve into the Mechanisms and Use of
Neural Transplants for Brain Repair, Reprogramming of Somatic
Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources:
Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for
the Treatment of Neurological Disorders, Preparation,
Characterization and Banking of Clinical-grade Cells for Neural
Transplantation. As the fourth in a periodic series of updates at
5-7 year intervals, this volume highlights recent developments
related to the application of advances in cellular and molecular
science, providing an understanding of the fundamental principles
of neuroplasticity and regeneration in the brain and spinal cord,
and also addressing the topic of the power of pluripotent stem
cells to generate new sources of precisely specified neurons for
utilization in brain repair.
This issue of "Progress in Brain Research" is split over 2 volumes,
bringing together cutting-edge research on functional neural
transplantation. The 2 volumes review current knowledge and
understanding, provide a starting point for researchers and
practitioners entering the field, and build a platform for further
research and discovery.
Leading authors review the state-of-the-art in their field of
investigation, and provide their views and perspectives for future
research
Chapters are extensively referenced to provide readers with a
comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are
written in a clear form that is also accessible to the
non-specialist
Movement is the way that animals interact with their environment
and is under the organization and complex control of the brain and
spinal cord. Multiple central nervous systems, including cortex,
basal ganglia, cerebellum, and brainstem, interact to provide
precise motor control and integration. Damage or disease within
these systems cause profound motor disturbances in man, which can
be effectively modeled in animals to develop a better understanding
and treatment of the human condition. Animal Models of Movement
Disorders introduces a variety of methods and techniques used to
model and assess motor function in experimental animals from lower
orders, such as drosophila and c. elegans, through vertebrate
species including fish, to mammals, such as rodents and non-human
primates. The most advanced contemporary models in each system are
presented at multiple levels of analysis from molecular and genetic
modeling, lesions, anatomy, neurochemistry, to imaging and
behavior. Volume II of this detailed collection contains sections
on the basal ganglia, neo- and allo-cortical systems, cerebellar
and brain stem systems, as well as spinal cord systems.
Comprehensive and meticulous, Animal Models of Movement Disorders
serves as a valuable reference for those studying motor disorders
by covering methodologies in detail and providing the information
necessary to consider both the appropriate models and assessment
tools that can most informatively answer the key experimental
issues in the field.
Functional Neural Transplantation IV: Translation to Clinical
Application, Part B, Volume 231 provides the current status of cell
transplantation in the nervous system, focusing on the conditions
for achieving structural repair and functional recovery. New to
this edition are chapters on Plasticity and Regeneration in the
Injured Spinal Cord After Cell Transplantation Therapy,
Transplantation of GABAergic Interneurons for Cell-Based Therapy,
Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic
Pain and Itch, From Transplanting Schwann Cells in Experimental Rat
Spinal Cord Injury to their Transplantation into Human Injured
Spinal Cord in Clinical Trials, and the Recruitment of Endogenous
CNS Stem Cells for Regeneration in Demyelinating Disease. As the
fourth in a periodic series of updates at 5-7 year intervals, this
volume highlights recent developments in cellular and molecular
science, providing the fundamental principles of neuroplasticity
and regeneration in the brain and spinal cord, while also
addressing the power of pluripotent stem cells to generate new
sources of precisely specified neurons for utilization in brain
repair.
This issue of Progress in Brain Research is split over 2 volumes,
bringing together cutting-edge research on Functional Neural
Transplantation. The 2 volumes review current knowledge and
understanding, provide a starting point for researchers and
practitioners entering the field, and build a platform for further
research and discovery.
Leading authors review the state-of-the-art in their field of
investigation, and provide their views and perspectives for future
research
Chapters are extensively referenced to provide readers with a
comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are
written in a clear form that is also accessible to the
non-specialist
Movement is the way that animals interact with their environment
and is under the organization and complex control of the brain and
spinal cord. Multiple central nervous systems, including cortex,
basal ganglia, cerebellum, and brainstem, interact to provide
precise motor control and integration. Damage or disease within
these systems cause profound motor disturbances in man, which can
be effectively modeled in animals to develop a better understanding
and treatment of the human condition. Animal Models of Movement
Disorders introduces a variety of methods and techniques used to
model and assess motor function in experimental animals from lower
orders, such as drosophila and c. elegans, through vertebrate
species including fish, to mammals, such as rodents and non-human
primates. The most advanced contemporary models in each system are
presented at multiple levels of analysis from molecular and genetic
modeling, lesions, anatomy, neurochemistry, to imaging and
behavior. Volume I contains general methods of movement disorder
assessment as well as an extensive section on dopamine systems.
Comprehensive and meticulous, Animal Models of Movement Disorders
serves as a valuable reference for those studying motor disorders
by covering methodologies in detail and providing the information
necessary to consider both the appropriate models and assessment
tools that can most informatively answer the key experimental
issues in the field.
This detailed book provides a laboratory manual and guidebook for
the selection, implementation, and interpretation of a wide range
of techniques in contemporary use in leading laboratories engaged
in Huntington's disease (HD) research worldwide. Only by
understanding the pathology and pathogenic process at the
fundamental molecular and cellular level can the research community
expect to be able to slow or halt the disease process, repair the
damage, and develop novel effective therapies to treat the symptoms
of this condition, thus this volume collects the practical
knowledge of its authors. Written for the highly successful Methods
in Molecular Biology series, chapters include introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and tips on troubleshooting and avoiding known pitfalls.
Authoritative and invaluable, Huntington's Disease aims to help
scientists to significantly extend the breadth and quality of
research in laboratories dedicated to mastering and controlling
this devastating human condition.
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